Syncopes, paresis and loss of vision after COVID-19 mRNA-based vaccination and SARS-CoV-2 infection

Faksova K, Walsh D, Jiang Y, Griffin J, Phillips A, Gentile A, Kwong JC, Macartney K, Naus M, Grange Z, Escolano S, Sepulveda G, Shetty A, Pillsbury A, Sullivan C, Naveed Z, Janjua NZ, Giglio N, Perälä J, Nasreen S, Gidding H, Hovi P, Vo T, Cui F, Deng L, Cullen L, Artama M, Lu H, Clothier HJ, Batty K, Paynter J, Petousis-Harris H, Buttery J, Black S, Hviid A. COVID-19 vaccines and adverse events of special interest: a multinational global vaccine data network (GVDN) cohort study of 99 million vaccinated individuals. Vaccine. 2024;42:2200–11. https://doi.org/10.1016/j.vaccine.2024.01.100. (Epub 2024 Feb 12 PMID: 38350768).

Article  CAS  PubMed  Google Scholar 

Schwab C, Domke LM, Hartmann L, Stenzinger A, Longerich T, Schirmacher P. Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination. Clin Res Cardiol. 2023;112:431–40. https://doi.org/10.1007/s00392-022-02129-5. (Epub 2022 Nov 27. PMID: 36436002; PMCID: PMC9702955).

Article  CAS  PubMed  Google Scholar 

Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA. 2020;324:782–93. https://doi.org/10.1001/jama.2020.12839. (PMID: 32648899).

Article  CAS  PubMed  Google Scholar 

Alimohamadi Y, Tola HH, Abbasi-Ghahramanloo A, Janani M, Sepandi M. Case fatality rate of COVID-19: a systematic review and meta-analysis. J Prev Med Hyg. 2021;62:E311–20. https://doi.org/10.15167/2421-4248/jpmh2021.62.2.1627.

Article  PubMed  PubMed Central  Google Scholar 

Ioannidis JPA. Infection fatality rate of COVID-19 inferred from seroprevalence data. Bull World Health Organ. 2021;99:19-33F. https://doi.org/10.2471/BLT.20.265892. (Epub 2020 Oct 14. PMID: 33716331; PMCID: PMC7947934).

Article  PubMed  Google Scholar 

Garg S, Kim L, Whitaker M, et al. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019—COVID-NET, 14 States, March 1–30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:458–64. https://doi.org/10.15585/mmwr.mm6915e3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morgan G, Casalino S, Chowdhary S, Frangione E, Fung CYJ, Haller S, Lapadula E, Scott M, Wolday D, Young J, Arnoldo S, Aujla N, Bearss E, Binnie A, Bombard Y, Borgundvaag B, Briollais L, Dagher M, Devine L, Faghfoury H, Friedman SM, Gingras AC, Goneau LW, Khan Z, Mazzulli T, McLeod SL, Nomigolzar R, Noor A, Pugh TJ, Richardson D, Satnam Singh HK, Simpson J, Stern S, Strug L, Taher A, Lerner-Ellis J, Taher J. Characterizing risk factors for hospitalization and clinical characteristics in a cohort of COVID-19 patients enrolled in the GENCOV study. Viruses. 2023;15:1764. https://doi.org/10.3390/v15081764.PMID:37632107;PMCID:PMC10457914.

Article  PubMed  PubMed Central  Google Scholar 

Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis. 2022;22:1293–302. https://doi.org/10.1016/S1473-3099(22)00320-6. (Epub 2022 Jun 23. Erratum in: Lancet Infect Dis. 2023 Oct;23(10):e400. PMID: 35753318; PMCID: PMC9225255).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yasmin F, Najeeb H, Naeem U, Moeed A, Atif AR, Asghar MS, Nimri N, Saleem M, Bandyopadhyay D, Krittanawong C, Fadelallah Eljack MM, Tahir MJ, Waqar F. Adverse events following COVID-19 mRNA vaccines: a systematic review of cardiovascular complication, thrombosis, and thrombocytopenia. Immun Inflamm Dis. 2023;11: e807. https://doi.org/10.1002/iid3.807. (PMID:36988252;PMCID:PMC10022421).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghoweba M, Sabayon MD. Syncope with sinus arrest following a single dose of a COVID-19 vaccine. Cureus. 2023;15: e34309. https://doi.org/10.7759/cureus.34309. (PMID:36860236;PMCID:PMC9970110).

Article  PubMed  PubMed Central  Google Scholar 

Ojo A, Goldenberg I, Kutyifa V, Aktas MK, Rosero S, Ayinde H, Huang DT. Recurrent ventricular tachycardia in a patient with COVID-19 vaccine-associated myocarditis: a case report. Ann Transl Med. 2023;11:267. https://doi.org/10.21037/atm-22-4164. (Epub 2023 Feb 20. PMID: 37082660; PMCID: PMC10113094).

Article  PubMed  PubMed Central  Google Scholar 

Altermanini M, Habib MB, Alkhiyami D, Ali K, Abdelghani MS, Hamamyh T, Elyas A, Elhassan M. Syncope following Pfizer BioNTech (bnt162b2) vaccination unmasking Brugada syndrome. Heliyon. 2023;9: e18716. https://doi.org/10.1016/j.heliyon.2023.e18716. (PMID:37576199;PMCID:PMC10415666).

Article  PubMed  PubMed Central  Google Scholar 

Barda N, Dagan N, Ben-Shlomo Y, Kepten E, Waxman J, Ohana R, Hernán MA, Lipsitch M, Kohane I, Netzer D, Reis BY, Balicer RD. Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Na:onwide SeÉng. N Engl J Med. 2021;385:1078–90. https://doi.org/10.1056/NEJMoa2110475. (Epub 2021 Aug 25. PMID: 34432976; PMCID: PMC8427535).

Article  CAS  PubMed  Google Scholar 

Mörz M. A case report: Mul:focal Necro:zing Encephali:s and Myocardi:s aPer BNT162b2 mRNA Vaccina:on against COVID-19. Vaccines (Basel). 2022;10:1651. https://doi.org/10.3390/vaccines10101651. (PMID: 36298516; PMCID: PMC9611676).

Article  CAS  PubMed  Google Scholar 

Sicherheitsbericht / Safety Report of the Paul-Ehrlich-Institut (04.05.2022). https://www.pei.de/SharedDocs/Downloads/DE/newsroom/dossiers/sicherheitsberichte/sicherheitsbericht-27-12-20-bis-31-03-22.pdf?__blob=publicationFile&v=5. Accessed: 18 Apr 2024

Salsone M, Signorelli C, Oldani A, Alber VF, Castronovo V, Mazzitelli S, Minerva M, Ferini-Strambi L. NEURO-COVAX: an Italian population-based study of neurological complica:onsaPer COVID-19 vaccina:ons. Vaccines (Basel). 2023;11:1621. https://doi.org/10.3390/vaccines11101621. (PMID: 37897023; PMCID: PMC10610846).

Article  CAS  PubMed  Google Scholar 

Gambichler T, Boms S, Susok L, Dickel H, Finis C, Abu Rached N, Barras M, Stücker M, Kasakovski D. Cutaneous findings following COVID-19 vaccination: review of world literature and own experience. J Eur Acad Dermatol Venereol. 2022;36:172–80. https://doi.org/10.1111/jdv.17744. (Epub 2021 Nov 2. PMID: 34661927; PMCID: PMC8656409).

Article  CAS  PubMed  Google Scholar 

Robinson LB, Fu X, Hashimoto D, et al. Incidence of cutaneous reactions after messenger RNA COVID-19 vaccines. JAMA Dermatol. 2021;157:1000–2. https://doi.org/10.1001/jamadermatol.2021.2114.

Article  PubMed  PubMed Central  Google Scholar 

Sarıgül Sezenöz A, Güngör SG, Kibaroğlu S. A case of transient visual field defect following administration of Pfizer-BioNTech COVID-19 vaccine. Ocul Immunol Inflamm. 2022;30:1255–9. https://doi.org/10.1080/09273948.2022.2055578. (Epub 2022 Apr 11 PMID: 35404749).

Article  CAS  PubMed  Google Scholar 

Jumroendararasame C, Panyakorn S, Othong R, Jumroendararasame A, Srimanan W, Tipparut K. Transient visual field loss after COVID-19 vaccination: experienced by ophthalmologist, case report. Am J Ophthalmol Case Rep. 2021;24:101212. https://doi.org/10.1016/j.ajoc.2021.101212. (Epub 2021 Sep 23. PMID: 34580649; PMCID: PMC8457908).

Article  PubMed  PubMed Central  Google Scholar 

Finsterer J. A case report: long post-COVID vaccination syndrome during the eleven months after the third moderna dose. Cureus. 2022;14: e32433. https://doi.org/10.7759/cureus.32433. (PMID:36644105;PMCID:PMC9833629).

Article  PubMed  PubMed Central  Google Scholar 

Hou X, Zaks T, Langer R, Dong Y. Lipid nanoparticles for mRNA delivery. Nat Rev Mater. 2021;6:1078–94. https://doi.org/10.1038/s41578-021-00358-0. (Epub 2021 Aug 10. PMID: 34394960; PMCID: PMC8353930).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guimarães LE, Baker B, Perricone C, Shoenfeld Y. Vaccines, adjuvants and autoimmunity. Pharmacol Res. 2015;100:190–209. https://doi.org/10.1016/j.phrs.2015.08.003. (Epub 2015 Aug 12. PMID: 26275795; PMCID: PMC7129276).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arnold DT, Milne A, Samms E, Stadon L, Maskell NA, Hamilton FW. Symptoms after COVID-19 vaccination in patients with persistent symptoms after acute infection: a case series. Ann Intern Med. 2021;174:1334–6. https://doi.org/10.7326/M21-1976. (Epub 2021 May 25. PMID: 34029484; PMCID: PMC8252827).

Article  PubMed  Google Scholar 

Strain WD, Sherwood O, Banerjee A, Van der Togt V, Hishmeh L, Rossman J. The impact of COVID vaccination on symptoms of long COVID: an international survey of people with lived experience of long COVID. Vaccines (Basel). 2022;10:652. https://doi.org/10.3390/vaccines10050652. (PMID:35632408;PMCID:PMC9146071).

Article  CAS  PubMed  Google Scholar 

Ayoubkhani D, Bermingham C, Pouwels KB, Glickman M, Nafilyan V, Zaccardi F, Khunti K, Alwan NA, Walker AS. Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study. BMJ. 2022;18: e069676. https://doi.org/10.1136/bmj-2021-069676. (PMID:35584816;PMCID:PMC9115603).

Article  Google Scholar 

Comments (0)

No login
gif