THRA1/PGC-1α/SIRT3 pathway regulates oxidative stress and is implicated in hypertension of maternal hypothyroid rat offspring

Global Burden of Cardiovascular Diseases C, Roth GA, Johnson CO, Abate KH, Abd-Allah F, Ahmed M, et al. The burden of cardiovascular diseases among US States, 1990-2016. JAMA Cardiol. 2018;3:375–89.

Article  Google Scholar 

Colafella KMM, Denton KM. Sex-specific differences in hypertension and associated cardiovascular disease. Nat Rev Nephrol. 2018;14:185–201.

Article  PubMed  Google Scholar 

Webster AL, Yan MS, Marsden PA. Epigenetics and cardiovascular disease. Can J Cardiol. 2013;29:46–57.

Article  PubMed  Google Scholar 

Barker DJ. Fetal origins of coronary heart disease. BMJ. 1995;311:171–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Visentin S, Grumolato F, Nardelli GB, Di Camillo B, Grisan E, Cosmi E. Early origins of adult disease: low birth weight and vascular remodeling. Atherosclerosis. 2014;237:391–9.

Article  CAS  PubMed  Google Scholar 

Langley-Evans SC. Fetal programming of CVD and renal disease: animal models and mechanistic considerations. Proc Nutr Soc. 2013;72:317–25.

Article  PubMed  Google Scholar 

Rodriguez-Rodriguez P, Ramiro-Cortijo D, Reyes-Hernandez CG, Lopez de Pablo AL, Gonzalez MC, Arribas SM. Implication of oxidative stress in fetal programming of cardiovascular disease. Front Physiol. 2018;9:602.

Article  PubMed  PubMed Central  Google Scholar 

Barker DJ. The origins of the developmental origins theory. J Intern Med. 2007;261:412–7.

Article  CAS  PubMed  Google Scholar 

Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension. 2020;75:285–92.

Article  CAS  PubMed  Google Scholar 

Son JS, Choi S, Kim K, Kim SM, Choi D, Lee G, et al. Association of blood pressure classification in korean young adults according to the 2017 American College of Cardiology/American Heart Association Guidelines With Subsequent Cardiovascular Disease Events. JAMA. 2018;320:1783–92.

Article  PubMed  PubMed Central  Google Scholar 

Kjeldsen SE. Hypertension and cardiovascular risk: General aspects. Pharm Res. 2018;129:95–9.

Article  Google Scholar 

Forhead AJ, Fowden AL. Thyroid hormones in fetal growth and prepartum maturation. J Endocrinol 2014;221:R87–103.

Article  CAS  PubMed  Google Scholar 

Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997;18:404–33.

Article  CAS  PubMed  Google Scholar 

Chattergoon NN, Giraud GD, Louey S, Stork P, Fowden AL, Thornburg KL. Thyroid hormone drives fetal cardiomyocyte maturation. Faseb j. 2012;26:397–408.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bryant SN, Nelson DB, McIntire DD, Casey BM, Cunningham FG. An analysis of population-based prenatal screening for overt hypothyroidism. Am J Obstet Gynecol. 2015;213:565.e1–6.

Article  CAS  PubMed  Google Scholar 

Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A, Rees R, et al. Antenatal thyroid screening and childhood cognitive function. N. Engl J Med. 2012;366:493–501.

Article  CAS  PubMed  Google Scholar 

Moleti M, Lo Presti VP, Mattina F, Mancuso A, De Vivo A, Giorgianni G, et al. Gestational thyroid function abnormalities in conditions of mild iodine deficiency: early screening versus continuous monitoring of maternal thyroid status. Eur J Endocrinol. 2009;160:611–7.

Article  CAS  PubMed  Google Scholar 

Sahu MT, Das V, Mittal S, Agarwal A, Sahu M. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Arch Gynecol Obstet. 2010;281:215–20.

Article  PubMed  Google Scholar 

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, et al. Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study. J Clin Endocrinol Metab. 2009;94:772–9.

Article  PubMed  Google Scholar 

Casey BM, Thom EA, Peaceman AM, Varner MW, Sorokin Y, Hirtz DG, et al. Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy. N. Engl J Med. 2017;376:815–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horacek J, Spitalnikova S, Dlabalova B, Malirova E, Vizda J, Svilias I, et al. Universal screening detects two-times more thyroid disorders in early pregnancy than targeted high-risk case finding. Eur J Endocrinol. 2010;163:645–50.

Article  CAS  PubMed  Google Scholar 

Rytter D, Andersen SL, Bech BH, Halldorsson TI, Henriksen TB, Laurberg P, et al. Maternal thyroid function in pregnancy may program offspring blood pressure, but not adiposity at 20 y of age. Pediatr Res. 2016;80:7–13.

Article  CAS  PubMed  Google Scholar 

Grattan MJ, Thomas DS, Hornberger LK, Hamilton RM, Midodzi WK, Vohra S. Maternal hypothyroidism may be associated with CHD in offspring. Cardiol Young-. 2015;25:1247–53.

Article  PubMed  Google Scholar 

Miao M, Liu H, Yuan W, Madsen N, Yu Y, László KD, et al. Association of maternal hypothyroidism with cardiovascular diseases in the offspring. Front Endocrinol (Lausanne). 2021;12:739629.

Article  PubMed  Google Scholar 

Santos SO, Loureiro SM, Alves IG, Jesus CS, Santos PR, Santos MR, et al. Experimental gestational hypothyroidism evokes hypertension in adult offspring rats. Auton Neurosci. 2012;170:36–41.

Article  CAS  PubMed  Google Scholar 

Gaynullina DK, Sofronova SI, Selivanova EK, Shvetsova AA, Borzykh AA, Sharova AP, et al. NO-mediated anticontractile effect of the endothelium is abolished in coronary arteries of adult rats with antenatal/early postnatal hypothyroidism. Nitric Oxide. 2017;63:21–8.

Article  CAS  PubMed  Google Scholar 

Guo J, Yu X, Liu Y, Lu L, Zhu D, Zhang Y, et al. Prenatal hypothyroidism diminished exogenous NO-mediated diastolic effects in fetal rat thoracic aorta smooth muscle via increased oxidative stress. Reprod Toxicol. 2022;113:52–61.

Article  CAS  PubMed  Google Scholar 

Miller FJ Jr. Hypertension and mitochondrial oxidative stress revisited: sirtuin 3, the improved “antioxidant”. Circ Res. 2020;126:453–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu HY, Hong FF, Yang SL. The roles of nitric oxide synthase/nitric oxide pathway in the pathology of vascular dementia and related therapeutic approaches. Int J Mol Sci. 2021;22:4540.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Erdamar H, Demirci H, Yaman H, Erbil MK, Yakar T, Sancak B, et al. The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med. 2008;46:1004–10.

Article  CAS  PubMed  Google Scholar 

Riis KR, Larsen CB, Medici BR, Jensen CZ, Winther KH, Larsen EL, et al. Hypothyroid women have persistently higher oxidative stress compared to healthy controls. Eur Thyroid J. 2023;12:e230167.

CAS  PubMed  PubMed Central  Google Scholar 

Venditti P, Di Meo S. Thyroid hormone-induced oxidative stress. Cell Mol Life Sci. 2006;63:414–34.

Article  CAS  PubMed 

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