Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 71 - 77
DOI: 10.13189/app.2025.130108
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Mohamed Bonewendé Belemlilga 1,2,*, Mathieu Nitiema 1,2, Aristide Traore 1, Eric Nanema 1, Souleymane Compaore 1,2, G. Geoffroy Ouedraogo 1,2, Sylvain Ilboudo 1,2, Lazare Belemnaba 1,2, Noufou Ouedraogo 1,2, Félix B. Kini 1, Sylvin Ouedraogo 1
1 Laboratory for Research and Development of Phytomedicines and Medicines (LR-D/PM), Research Institute of Health Sciences (IRSS), National Center for Scientific and Technological Research (CNRST), Burkina Faso
2 International Research Laboratory - Environment, Health, Society (IRL 3189, ESS) CNRS/CNRST/UCAD/UGB/USTTB, Burkina Faso

ABSTRACT

Boscia senegalensis is a shrub from semi-arid regions used to treat various pathologies, including inflammation. The aqueous macerate of the leaves was subjected to phytochemical and biological studies to demonstrate its anti-inflammatory properties and safety. The anti-inflammatory carrageenan test and the analgesic acetic acid test were performed. Phytochemical screening of the leaves revealed mainly tannins, flavonoids, sterol glycosides and triterpenes. The LD50 value was 5000 mg/kg. The plant material would, therefore, be classified as having very low toxicity. The evaluation of the anti-edematous activity showed that Boscia senegalensis extract showed the best anti-edematous activity at 1 h with 92.34% ± 0.44 at 500 mg/kg. At the same time, aspegic at 125 mg/kg and betamethasone at 20 mg/kg, used as references, gave 58.51% ± 4.92 and 82.29% ± 2.02, respectively. In the analgesia test, the mean number of contortions was 33 ± 2.64 at 500 mg/kg bw, compared with 30 ± 1.52 for acetaminophen at 100 mg/kg bw. These results justify using the plant in traditional medicine to treat specific pathologies with inflammatory manifestations, such as cough, pain and diarrhoea.

KEYWORDS
Boscia senegalensis, Acute Toxicity, Anti-oedematous, Analgesic, Aqueous Macerate

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Mohamed Bonewendé Belemlilga , Mathieu Nitiema , Aristide Traore , Eric Nanema , Souleymane Compaore , G. Geoffroy Ouedraogo , Sylvain Ilboudo , Lazare Belemnaba , Noufou Ouedraogo , Félix B. Kini , Sylvin Ouedraogo , "Evaluation of Anti-inflammatory Activities and Acute Toxicity of the Leaves Aqueous Macerate of Boscia senegalensis (Pers.). Lam. Ex. Poir (Capparaceae)," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 71 - 77, 2025. DOI: 10.13189/app.2025.130108.

(b). APA Format:
Mohamed Bonewendé Belemlilga , Mathieu Nitiema , Aristide Traore , Eric Nanema , Souleymane Compaore , G. Geoffroy Ouedraogo , Sylvain Ilboudo , Lazare Belemnaba , Noufou Ouedraogo , Félix B. Kini , Sylvin Ouedraogo (2025). Evaluation of Anti-inflammatory Activities and Acute Toxicity of the Leaves Aqueous Macerate of Boscia senegalensis (Pers.). Lam. Ex. Poir (Capparaceae). Advances in Pharmacology and Pharmacy, 13(1), 71 - 77. DOI: 10.13189/app.2025.130108.