METTL14 inhibits Aβ1-42-induced neuronal injury through regulating the stability of CBLN4 mRNA in Alzheimer’s disease

(2023) Alzheimer’s disease facts and figures. Alzheimer’s & dementia: the journal of the Alzheimer’s Association 2023, 19(4):1598–1695

Breijyeh Z, Karaman R (2020) Comprehensive Review on Alzheimer’s Disease: Causes and Treatment. Molecules 25(24)

Bourgeron T (2015) From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci 16(9):551–563

Article  PubMed  CAS  Google Scholar 

Chacón PJ, del Marco Á, Arévalo Á, Domínguez-Giménez P, García-Segura LM, Rodríguez-Tébar A (2015) Cerebellin 4, a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-β toxicity. Neurobiol Aging 36(2):1057–1071

Article  PubMed  Google Scholar 

Citron M (2010) Alzheimer’s disease: strategies for disease modification. Nat Rev Drug Discovery 9(5):387–398

Article  PubMed  CAS  Google Scholar 

Deng Y, Zhu H, Xiao L, Liu C, Liu YL, Gao W (2021) Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer’s disease. Aging 13(21):24086–24100

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gerakis Y, Hetz C (2018) Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer’s disease. FEBS J 285(6):995–1011

Article  PubMed  CAS  Google Scholar 

Hampel H, Hu Y, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M et al (2023) The amyloid-β pathway in Alzheimer’s disease: a plain language summary. Neurodegenerative Disease Manage 13(3):141–149

Article  CAS  Google Scholar 

He PC, He C (2021) M(6) a RNA methylation: from mechanisms to therapeutic potential. EMBO J 40(3):e105977

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hugon J, Mouton-Liger F, Dumurgier J, Paquet C (2017) PKR involvement in Alzheimer’s disease. Alzheimers Res Ther 9(1):83

Article  PubMed  PubMed Central  Google Scholar 

Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17(6):157–165

Article  PubMed  CAS  Google Scholar 

Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X et al (2014) A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol 10(2):93–95

Article  PubMed  CAS  Google Scholar 

Liu X, Wang Y (2023) Elucidating the molecular targets and mechanisms of Chlorogenic Acid against Alzheimer’s Disease via Network Pharmacology and Molecular Docking. Lett Drug Des Discovery 20(9):1329–1342

Article  CAS  Google Scholar 

Lv Z, Xu T, Li R, Zheng D, Li Y, Li W, Yang Y, Hao Y (2022) Downregulation of m6A methyltransferase in the Hippocampus of Tyrobp (-/-) mice and implications for learning and memory deficits. Front NeuroSci 16:739201

Murakami S, Jaffrey SR (2022) Hidden codes in mRNA: control of gene expression by m(6)a. Mol Cell 82(12):2236–2251

Article  PubMed  PubMed Central  CAS  Google Scholar 

Meyer KD, Jaffrey SR (2014) The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol 15(5):313–326

Article  PubMed  PubMed Central  CAS  Google Scholar 

Meng S, Wang B, Li W (2022) CircAXL Knockdown alleviates Aβ(1–42)-Induced neurotoxicity in Alzheimer’s Disease via repressing PDE4A by releasing miR-1306-5p. Neurochem Res 47(6):1707–1720

Article  PubMed  PubMed Central  CAS  Google Scholar 

Salaikumaran Raj M, Prasad Burra Laxmi Siva V (2023) <i > in silico design of novel SAM analogs as potential inhibitors against N2G966 16s rRNA methyltransferase (RsmD)</i >. Lett Drug Des Discovery 20(12):1898–1910

Article  Google Scholar 

Sanfilippo C, Musumeci G, Kazakova M, Mazzone V, Castrogiovanni P, Imbesi R, Di Rosa M (2021) GNG13 is a potential marker of the state of Health of Alzheimer’s Disease patients’ Cerebellum. J Mol Neuroscience: MN 71(5):1046–1060

Article  CAS  Google Scholar 

Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J, van der Flier WM (2021) Alzheimer’s disease. Lancet (London England) 397(10284):1577–1590

Article  PubMed  CAS  Google Scholar 

Sehar U, Rawat P, Reddy AP, Kopel J, Reddy PH (2022) Amyloid Beta in Aging and Alzheimer’s Disease. Int J Mol Sci 23(21)

Seigneur E, Südhof TC (2017) Cerebellins are differentially expressed in selective subsets of neurons throughout the brain. J Comp Neurol 525(15):3286–3311

Article  PubMed  PubMed Central  CAS  Google Scholar 

Śledź P, Jinek M (2016) Structural insights into the molecular mechanism of the m(6)a writer complex. eLife 5

Shafik AM, Zhang F, Guo Z, Dai Q, Pajdzik K, Li Y, Kang Y, Yao B, Wu H, He C et al (2021) N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease. Genome Biol 22(1):17

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang Z, Cao J, Yao J, Fan X, Zhao J, Zhao M, Duan Q, Han B, Duan S (2023) KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer’s disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1. Free Radic Biol Med 195:343–358

Article  PubMed  CAS  Google Scholar 

Wang H, Jiang T, Li W, Gao N, Zhang T (2018) Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease. Toxicol Lett 282:100–108

Article  PubMed  CAS  Google Scholar 

Wang J, Zheng B, Yang S, Wang F, Wang Z, Wang J (2021) The protective effects of agomelatine against Aβ1–42 oligomers-induced cellular senescence mediated by SIRT6 and Agomelatine’s potential in AD treatment. Hum Cell 34(6):1734–1743

Article  PubMed  CAS  Google Scholar 

Wei P, Pattarini R, Rong Y, Guo H, Bansal PK, Kusnoor SV, Deutch AY, Parris J, Morgan JI (2012) The Cbln family of proteins interact with multiple signaling pathways. J Neurochem 121(5):717–729

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xia L, Zhang F, Li Y, Mo Y, Zhang L, Li Q, Luo M, Hou X, Du Z, Deng J et al (2023) A new perspective on Alzheimer’s disease: m6A modification. Front Genet 14:1166831

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yang Y, Hsu PJ, Chen YS, Yang YG (2018) Dynamic transcriptomic m(6)a decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res 28(6):616–624

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang N, Ding C, Zuo Y, Peng Y, Zuo L (2022) N6-methyladenosine and neurological diseases. Mol Neurobiol 59(3):1925–1937

Article  PubMed  CAS  Google Scholar 

Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W et al (2021) METTL3-dependent RNA m(6)a dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events. Mol Neurodegeneration 16(1):70

Article  Google Scholar 

Zhang TP, Li R, Wang LJ, Huang Q, Li HM (2022) Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis. Front Immunol 13:992628

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang XX, Tian Y, Wang ZT, Ma YH, Tan L, Yu JT (2021) The epidemiology of Alzheimer’s Disease Modifiable Risk factors and Prevention. J Prev Alzheimer’s Disease 8(3):313–321

Google Scholar 

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