Comparative analysis of hypofractionated short-course versus standard radiation therapy in elderly patients with glioblastoma: analysis of nationwide database

Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C et al (2023) CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2016–2020. Neuro Oncol 25(12 Suppl 2):iv1–iv99. https://doi.org/10.1093/neuonc/noad149

Article  PubMed  PubMed Central  Google Scholar 

Alexander BM, Cloughesy TF (2017) Adult glioblastoma. J Clin Oncol 35(21):2402–2409. https://doi.org/10.1200/JCO.2017.73.0119

Article  PubMed  CAS  Google Scholar 

Kang H, Song SW, Ha J, Won YJ, Park CK, Yoo H et al (2021) A Nationwide, Population-based Epidemiology Study of Primary Central Nervous System tumors in Korea, 2007–2016: a comparison with United States Data. Cancer Res Treat 53(2):355–366. https://doi.org/10.4143/crt.2020.847

Article  PubMed  Google Scholar 

Mohammed S, Dinesan M, Ajayakumar T (2022) Survival and quality of life analysis in glioblastoma multiforme with adjuvant chemoradiotherapy: a retrospective study. Rep Pract Oncol Radiother 27(6):1026–1036. https://doi.org/10.5603/RPOR.a2022.0113

Article  PubMed  PubMed Central  Google Scholar 

Dubrow R, Darefsky AS (2011) Demographic variation in incidence of adult glioma by subtype, United States, 1992–2007. BMC Cancer 11:325. https://doi.org/10.1186/1471-2407-11-325

Article  PubMed  PubMed Central  Google Scholar 

NCCN (2024) NCCN Clinical Practice Guidelines in Oncology: Central Nervous System cancers. Version 1.2024. NCCN, Plymouth Meeting, PA

Google Scholar 

Cabrera AR, Kirkpatrick JP, Fiveash JB, Shih HA, Koay EJ, Lutz S et al (2016) Radiation therapy for glioblastoma: executive summary of an American Society for Radiation Oncology evidence-based clinical practice Guideline. Pract Radiat Oncol 6(4):217–225. https://doi.org/10.1016/j.prro.2016.03.007

Article  PubMed  Google Scholar 

Buatti J, Ryken TC, Smith MC, Sneed P, Suh JH, Mehta M et al (2008) Radiation therapy of pathologically confirmed newly diagnosed glioblastoma in adults. J Neurooncol 89(3):313–337. https://doi.org/10.1007/s11060-008-9617-2

Article  PubMed  Google Scholar 

Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A et al (2014) EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol 15(9):e395–403. https://doi.org/10.1016/s1470-2045(14)70011-7

Article  PubMed  Google Scholar 

Malmstrom A, Gronberg BH, Marosi C, Stupp R, Frappaz D, Schultz H et al (2012) Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the nordic randomised, phase 3 trial. Lancet Oncol 13(9):916–926. https://doi.org/10.1016/S1470-2045(12)70265-6

Article  PubMed  CAS  Google Scholar 

Roa W, Brasher PM, Bauman G, Anthes M, Bruera E, Chan A et al (2004) Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol 22(9):1583–1588. https://doi.org/10.1200/JCO.2004.06.082

Article  PubMed  CAS  Google Scholar 

Roa W, Kepka L, Kumar N, Sinaika V, Matiello J, Lomidze D et al (2015) International Atomic Energy Agency Randomized Phase III Study of Radiation Therapy in Elderly and/or frail patients with newly diagnosed Glioblastoma Multiforme. J Clin Oncol 33(35):4145–4150. https://doi.org/10.1200/JCO.2015.62.6606

Article  PubMed  Google Scholar 

Haque W, Verma V, Butler EB, Teh BS (2018) Patterns of Care and outcomes of Hypofractionated Chemoradiation Versus conventionally fractionated chemoradiation for Glioblastoma in the Elderly Population. Am J Clin Oncol 41(2):167–172. https://doi.org/10.1097/coc.0000000000000417

Article  PubMed  Google Scholar 

Mak KS, Agarwal A, Qureshi MM, Truong MT (2017) Hypofractionated short-course radiotherapy in elderly patients with glioblastoma multiforme: an analysis of the National Cancer Database. Cancer Med 6(6):1192–1200. https://doi.org/10.1002/cam4.1070

Article  PubMed  PubMed Central  CAS  Google Scholar 

Thibouw D, Truc G, Bertaut A, Chevalier C, Aubignac L, Mirjolet C (2018) Clinical and dosimetric study of radiotherapy for glioblastoma: three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy. J Neurooncol 137(2):429–438. https://doi.org/10.1007/s11060-017-2735-y

Article  PubMed  Google Scholar 

Navarria P, Pessina F, Cozzi L, Ascolese AM, Lobefalo F, Stravato A et al (2016) Can advanced new radiation therapy technologies improve outcome of high grade glioma (HGG) patients? Analysis of 3D-conformal radiotherapy (3DCRT) versus volumetric-modulated arc therapy (VMAT) in patients treated with surgery, concomitant and adjuvant chemo-radiotherapy. BMC Cancer 16(1):362. https://doi.org/10.1186/s12885-016-2399-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jun JK, Yoo K-Y (2019) National Cancer Control in Korea. In: Withers M, McCool J (eds) Global Health Leadership: Case studies from the Asia-Pacific. Springer International Publishing, Cham, pp 119–131

Chapter  Google Scholar 

Korea Health Infromation Service (2024) Health care data portal, Application for combined data. https://k-cure.mohw.go.kr/portal/cmm/htm/engApplicationCombine.do Accessed July 29 2024

WorldHealthOrganization (2024) International Classification of Diseases for Oncology. https://www.who.int/standards/classifications/other-classifications/international-classification-of-diseases-for-oncology Accessed June 22 2024

Austin PC, Stuart EA (2015) Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Stat Med 34(28):3661–3679. https://doi.org/10.1002/sim.6607

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Li S, Peng Y, Ma W, Wang Y, Li W (2023) Progress in phase III clinical trials of molecular targeted therapy and immunotherapy for glioblastoma. Cancer Innov 2(2):114–130. https://doi.org/10.1002/cai2.59

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ballo MT, Conlon P, Lavy-Shahaf G, Kinzel A, Vymazal J, Rulseh AM (2023) Association of Tumor Treating Fields (TTFields) therapy with survival in newly diagnosed glioblastoma: a systematic review and meta-analysis. J Neurooncol 164(1):1–9. https://doi.org/10.1007/s11060-023-04348-w

Article  PubMed  PubMed Central  Google Scholar 

Khan L, Soliman H, Sahgal A, Perry J, Xu W, Tsao MN (2020) External beam radiation dose escalation for high grade glioma. Cochrane Database Syst Rev 5(5):Cd011475. https://doi.org/10.1002/14651858.CD011475.pub3

Article  PubMed  Google Scholar 

Perry JR, Laperriere N, O’Callaghan CJ, Brandes AA, Menten J, Phillips C et al (2017) Short-course Radiation plus Temozolomide in Elderly patients with Glioblastoma. N Engl J Med 376(11):1027–1037. https://doi.org/10.1056/NEJMoa1611977

Article  PubMed  CAS  Google Scholar 

Wick A, Kessler T, Platten M, Meisner C, Bamberg M, Herrlinger U et al (2020) Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma. Neuro Oncol 22(8):1162–1172. https://doi.org/10.1093/neuonc/noaa033

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kim N, Lim DH, Choi JW, Lee JI, Kong DS, Seol HJ et al (2023) Clinical outcomes of moderately hypofractionated concurrent chemoradiotherapy for newly diagnosed Glioblastoma. Yonsei Med J 64(2):94–103. https://doi.org/10.3349/ymj.2022.0352

Article  PubMed  PubMed Central  CAS  Google Scholar 

McMahon SJ (2018) The linear quadratic model: usage, interpretation and challenges. Phys Med Biol 64(1):01tr. https://doi.org/10.1088/1361-6560/aaf26a

Article  CAS  Google Scholar 

Pedicini P, Fiorentino A, Simeon V, Tini P, Chiumento C, Pirtoli L et al (2014) Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes. Strahlenther Onkol 190(10):925–932. https://doi.org/10.1007/s00066-014-0638-9

Article  PubMed  Google Scholar 

Wee CW (2022) Radiotherapy for newly diagnosed Glioblastoma in the Elderly: what is the Standard? Brain Tumor Res Treat 10(1):12–21. https://doi.org/10.14791/btrt.2022.10.e34

Article  PubMed  PubMed Central  Google Scholar 

Trone JC, Vallard A, Sotton S, Ben Mrad M, Jmour O, Magne N et al (2020) Survival after hypofractionation in glioblastoma: a systematic review and meta-analysis. Radiat Oncol 15(1):145. https://doi.org/10.1186/s13014-020-01584-6

Article  PubMed 

Comments (0)

No login
gif