Cypess AM. Reassessing human adipose tissue. N Engl J Med. 2022;386(8):768–79.

Article  CAS  PubMed  Google Scholar 

Wu J, Bostrom P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150(2):366–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pilkington AC, Paz HA, Wankhade UD. beige adipose tissue identification and marker specificity-overview. Front Endocrinol (Lausanne). 2021;12: 599134.

Article  PubMed  Google Scholar 

•• Ruan CC, Kong LR, Chen XH, et al. A(2A) receptor activation attenuates hypertensive cardiac remodeling via promoting brown adipose tissue-derived FGF21. Cell Metab. 2018;28(3):476–89. This paper demonstrates that A2AR-mediated FGF21 release from brown adipose tissue plays an endocrine protective role against hypertensive cardiac remodeling.

Article  CAS  PubMed  Google Scholar 

•• Adachi Y, Ueda K, Nomura S, et al. Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling. Nat Commun. 2022;13(1):5117. This study demonstrates the pivotal roles of perivascular adipose tissue (PVAT) in vascular inflammation and remodeling.

Article  CAS  PubMed  PubMed Central  Google Scholar 

•• Zhao H, Chen X, Hu G, et al. Small extracellular vesicles from brown adipose tissue mediate exercise cardioprotection. Circ Res. 2022;130(10):1490–506. The small extracellular vesicles (sEVs) secreted by BAT participate in exercise cardioprotection via delivering the cardioprotective miRNAs into the heart.

Article  CAS  PubMed  Google Scholar 

•• Lin JR, Ding LL, Xu L, et al. Brown adipocyte ADRB3 mediates cardioprotection via suppressing exosomal iNOS. Circ Res. 2022;131(2):133–47. This study demonstrates that the activation of ADRB3 (β3-adrenergic receptors) in brown adipocytes offers cardiac protection through suppressing exosomal iNOS, illustrating an important role of ADRB3 in endocrine crosstalk between BAT and the heart.

Article  CAS  PubMed  Google Scholar 

Park A, Kim W, Bae K. Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells. World journal of stem cells. 2014;6(1):33–42.

Article  PubMed  PubMed Central  Google Scholar 

Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. 2001;60(3):329–39.

Article  CAS  PubMed  Google Scholar 

Scheja L, Heeren J. The endocrine function of adipose tissues in health and cardiometabolic disease. Nat Rev Endocrinol. 2019;15(9):507–24.

Article  CAS  PubMed  Google Scholar 

Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796–808.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perry RJ, Camporez JG, Kursawe R, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015;160(4):745–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Item F, Konrad D. Visceral fat and metabolic inflammation: the portal theory revisited. Obes Rev. 2012;13(Suppl 2):30–9.

Article  PubMed  Google Scholar 

Shamsi F, Wang CH, Tseng YH. The evolving view of thermogenic adipocytes - ontogeny, niche and function. Nat Rev Endocrinol. 2021;17(12):726–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carpentier AC, Blondin DP, Haman F, Richard D. Brown adipose tissue—a translational perspective. Endocr Rev. 2023;44(2):143–92.

Article  PubMed  Google Scholar 

Villarroya F, Cereijo R, Villarroya J, Giralt M. Brown adipose tissue as a secretory organ. Nat Rev Endocrinol. 2017;13(1):26–35.

Article  CAS  PubMed  Google Scholar 

Cannon B, Nedergaard JAN. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84(1):277–359.

Article  CAS  PubMed  Google Scholar 

Kajimura S, Spiegelman BM, Seale P. Brown and beige fat: physiological roles beyond heat generation. Cell Metab. 2015;22(4):546–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360(15):1518–25.

Article  CAS  PubMed  Google Scholar 

Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009;58(7):1526–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berry DC, Stenesen D, Zeve D, Graff JM. The developmental origins of adipose tissue. Development. 2013;140(19):3939–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenwald M, Perdikari A, Rulicke T, Wolfrum C. Bi-directional interconversion of brite and white adipocytes. Nat Cell Biol. 2013;15(6):659–67.

Article  CAS  PubMed  Google Scholar 

Seale P, Conroe HM, Estall J, et al. PRDM16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011;121(1).

Cohen P, Levy JD, Zhang Y, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014;156(1–2):304–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Ishibashi J, Trefely S, et al. A PRDM16-driven metabolic signal from adipocytes regulates precursor cell fate. Cell Metab. 2019;30(1).

Henegar C, Tordjman J, Achard V, et al. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 2008;9(1):R14.

Article  PubMed  PubMed Central  Google Scholar 

Muir LA, Neeley CK, Meyer KA, et al. Adipose tissue fibrosis, hypertrophy, and hyperplasia: correlations with diabetes in human obesity. Obesity. 2016;24(3):597–605.

Article  CAS  PubMed  Google Scholar 

Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med. 2013;19(10):1252–63.

Article  CAS  PubMed  Google Scholar 

Long JZ, Svensson KJ, Tsai L, et al. A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014;19(5):810–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oguri Y, Shinoda K, Kim H, et al. CD81 controls beige fat progenitor cell growth and energy balance via FAK signaling. Cell. 2020;182(3):563-577.e520.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 2014;10(1):24–36.

Article  CAS  PubMed  Google Scholar 

Giordano A, Smorlesi A, Frontini A, Barbatelli G, Cinti S. Mechanisms in endocrinology: white, brown and pink adipocytes: the extraordinary plasticity of the adipose organ. Eur J Endocrinol. 2014;170(5):R159–71.

Article  CAS