Somatostatin Versus Octreotide for Prevention of Postoperative Pancreatic Fistula: The PREFIPS Randomized Clinical Trial: A FRENCH 007—ACHBT Study

*Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, AP-HP Pitié-Salpêtrière Hospital, Paris, France

†Sorbonne University, Paris, France

‡Department of Oncology and Digestive Surgery, CHU Amiens-Picardie, Amiens, France

§University of Picardie Jules-Vernes, Amiens, France

‖Department of Digestive and Oncological Surgery, CHU Lille, Lille, France

¶University Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France

#Department of Digestive Surgery and Transplantation, CHU Lille, Lille, France

**Clinical Research Unit Necker Cochin Hospital, APHP, Paris, France

††Department of Digestive Surgery and Liver Transplantation, CHU Tours Trousseau, Tours, France

‡‡University of Tours, Tours, France

§§Department of Digestive and Hepatobiliary Surgery, Estaing Hospital, CHU Clermont-Ferrand, Clermont-Ferrand, France

‖‖Clermont-Ferrand Faculty of Medicine, Clermont-Ferrand, France

¶¶Digestive Surgery Unit, Edouard Herriot Hospital, Lyon, France

##Hospices Civils of Lyon University, Lyon, France

***Department of Digestive, Pancreatic, Hepatobiliary and Endocrine Surgery, Cochin Hospital, APHP, Paris, France

†††University of Paris, Paris, France

‡‡‡Digestive Surgery Department, Reims University Hospital, Robert Debré Hospital, Reims, France

§§§Reims University Hospital, Robert Debré Hospital, Reims, France

‖‖‖Digestive Surgery and Liver Transplantation Department, Toulouse University Hospital, Toulouse, France

¶¶¶Toulouse University, Toulouse, France

###Department of Hepatobiliary and Digestive Surgery Hospital Rennes, Rennes, France

****Rennes University, Rennes, France

††††Department of Digestive Surgery, Charles Nicolle Hospital, Rouen, France

‡‡‡‡Rouen University, Rouen, France

§§§§Department of Hepatobiliary Surgery and Liver Transplantation, Paul Brousse Hospital, Villejuif, France

‖‖‖‖Paris-Saclay University, Saclay, France

¶¶¶¶Department of Hepatobiliary Surgery, Beaujon Hospital, Clichy, France

####University Paris Cité, Paris, France

Because of the design of this multicentric randomized controlled open study, in several academic high-volume centers, there is more than 8 authors listed, that is, the principal investigators in each center. Associated investigators have been listed as collaborators. Collaborators: Hendy Abdoul, Olivier Antomarchi, Marc Boudon, Pr Nicolas Carrere, François Cauchy, Alexandre Chebaro, Daniel Cherqui, Thibault Crombe, Emmanuel Cuellar, Ariane D’avout, Charles de Ponthaud, Clément Dubois, Pr Isabelle Durand-Zaleski, Safi Dokmak, Mehdi El Amrani, Johan Gagniere, Anne Gandon, Brice Gayet, Elisabeth Hain, Florence Jeune, Vahan Kepenekian, Mahaut Leconte, Bertrand Leroy, Lena M'ba, Alexandru Mare, Frédéric Marques, Pierre-Philippe Massault, Alexandre Mensier, Guillaume Millet, Julie Navez, Julie Perinel, Elise Pelascani, Denis Pezet, Tullio Piardi, Gabriella Pittau, Mathieu Prodeau, Yohann Renard, Géraldine Rousseau, Anne-Sophie Schneck, Pr Karem Slim, Bertrand Suc, Nicolas Tabchouri, Boris Trechot, Ecoline Tribillon, Candice Tubbax, Pr Jean-Jacques Tuech, Stylianos Tzedakis.

Authors' contribution: S.G. had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

The research was funded by a grant from Programme Hospitalier de Recherche Clinique— PHRC 2015 (Ministère de la Santé).

The funders had no involvement in the design and conduct of the study; collection, management, analysis, andinterpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The Clinical Research Unit Center, Cochin Hospital, Paris, France reviewed the study protocol as part of the sponsorship review process.

The study was in the minority funded by Eumedica SA (7170 Manage, Belgium), which did not have access to data, did not participate in the data analysis and did not participate in the preparation of the manuscript other than reviewing it.

The sponsor of this study was Assistance Publique–Hôpitaux de Paris (Département de la Recherche Clinique et du Développement, Clinical Research and Development Department).

S.G. reported grants, personal fees, and nonfinancial support fomr IPSEN, Mylan, Mayoli, Novartis. The remaining authors report no conflicts of interest.

Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, www.annalsofsurgery.com.

[email protected].

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