Metabolic abnormalities in the bone marrow cells of young offspring born to mothers with obesity

Moholdt T, Hawley JA. Maternal lifestyle interventions: targeting preconception health. Trends Endocrinol Metab. 2020;31:561–9.

Article  CAS  PubMed  Google Scholar 

Bulik CM, Hardaway JA. Turning the tide on obesity? Science. 2023;381:463.

Article  PubMed  Google Scholar 

Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, et al. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat Genet. 2018;50:1505–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Driscoll AK, Gregory ECW. Increases in Prepregnancy Obesity: United States, 2016–2019. NCHS Data Brief. 2020;392:1–8.

Google Scholar 

Langley-Evans SC. Early life programming of health and disease: the long-term consequences of obesity in pregnancy. J Hum Nutr Diet. 2022;35:816–32.

Article  PubMed  PubMed Central  Google Scholar 

Leddy MA, Power ML, Schulkin J. The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol. 2008;1:170–8.

PubMed  PubMed Central  Google Scholar 

Segovia SA, Vickers MH, Gray C, Reynolds CM. Maternal obesity, inflammation, and developmental programming. Biomed Res Int. 2014;2014:418975.

Article  PubMed  PubMed Central  Google Scholar 

Bucher M, Montaniel KRC, Myatt L, Weintraub S, Tavori H, Maloyan A. Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers. J Dev Orig Health Dis. 2021;12:738–47.

Article  CAS  PubMed  Google Scholar 

Hu Z, Han L, Liu J, Fowke JH, Han JC, Kakhniashvili D, et al. Prenatal metabolomic profiles mediate the effect of maternal obesity on early childhood growth trajectories and obesity risk: the CANDLE study. Am J Clin Nutr. 2022;116:1343–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basu S, Haghiac M, Surace P, Challier JC, Guerre-Millo M, Singh K, et al. Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation. Obes (Silver Spring). 2011;19:476–82.

Article  CAS  Google Scholar 

Muralimanoharan S, Guo C, Myatt L, Maloyan A. Sexual dimorphism in miR-210 expression and mitochondrial dysfunction in the placenta with maternal obesity. Int J Obes (Lond). 2015;39:1274–81.

Article  CAS  PubMed  Google Scholar 

Suk D, Kwak T, Khawar N, Vanhorn S, Salafia CM, Gudavalli MB, et al. Increasing maternal body mass index during pregnancy increases neonatal intensive care unit admission in near and full-term infants. J Matern Fetal Neonatal Med. 2016;29:3249–53.

PubMed  Google Scholar 

Griffiths PS, Walton C, Samsell L, Perez MK, Piedimonte G. Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring. Pediatr Res. 2016;79:278–86.

Article  PubMed  Google Scholar 

Dumas O, Varraso R, Gillman MW, Field AE, Camargo CA Jr. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy. 2016;71:1295–304.

Article  CAS  PubMed  Google Scholar 

Guerra S, Sartini C, Mendez M, Morales E, Guxens M, Basterrechea M, et al. Maternal prepregnancy obesity is an independent risk factor for frequent wheezing in infants by age 14 months. Paediatr Perinat Epidemiol. 2013;27:100–8.

Article  PubMed  Google Scholar 

Morgan AR, Thompson JM, Murphy R, Black PN, Lam WJ, Ferguson LR, et al. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. BMC Med Genet. 2010;11:125.

Article  PubMed  PubMed Central  Google Scholar 

Eriksson JG, Sandboge S, Salonen MK, Kajantie E, Osmond C. Long-term consequences of maternal overweight in pregnancy on offspring later health: findings from the Helsinki Birth Cohort Study. Ann Med. 2014;46:434–8.

Article  PubMed  Google Scholar 

Lucas D. Structural organization of the bone marrow and its role in hematopoiesis. Curr Opin Hematol. 2021;28:36–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benova A, Tencerova M. Obesity-Induced Changes in Bone Marrow Homeostasis. Front Endocrinol. 2020;11:294.

Article  Google Scholar 

Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, et al. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab. 2014;19:821–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singer K, DelProposto J, Morris DL, Zamarron B, Mergian T, Maley N, et al. Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells. Mol Metab. 2014;3:664–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, et al. Bone marrow endothelial cells regulate myelopoiesis in diabetes mellitus. Circulation. 2020;142:244–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mulder WJM, Ochando J, Joosten LAB, Fayad ZA, Netea MG. Therapeutic targeting of trained immunity. Nat Rev Drug Discov. 2019;18:553–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, et al. Trained immunity: a program of innate immune memory in health and disease. Science. 2016;352:aaf1098.

Article  PubMed  PubMed Central  Google Scholar 

Calco GN, Alharithi YJ, Williams KR, Jacoby DB, Fryer AD, Maloyan A, et al. Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring. Am J Physiol Lung Cell Mol Physiol. 2023;325:L66–l73.

Article  CAS  PubMed  Google Scholar 

Montaniel KRC, Bucher M, Phillips EA, Li C, Sullivan EL, Kievit P, et al. Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers. J Dev Orig Health Dis. 2022;13:727–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Quan N. Immune cell isolation from mouse femur bone marrow. Bio Protoc. 2015;5:e1631.

Article  PubMed  Google Scholar 

Phillips EA, Hendricks N, Bucher M, Maloyan A. Vitamin D supplementation improves mitochondrial function and reduces inflammation in placentae of obese women. Front Endocrinol (Lausanne). 2022;13:893848.

Article  PubMed  Google Scholar 

Ruffell B, Au A, Rugo HS, Esserman LJ, Hwang ES, Coussens LM. Leukocyte composition of human breast cancer. Proc Natl Acad Sci USA. 2012;109:2796–801.

Article  CAS  PubMed  Google Scholar 

Tall AR, Yvan-Charvet L, Westerterp M, Murphy AJ. Cholesterol efflux: a novel regulator of myelopoiesis and atherogenesis. Arterioscler Thromb Vasc Biol. 2012;32:2547–52.

Article  CAS  PubMed  Google Scholar 

TeSlaa T, Ralser M, Fan J, Rabinowitz JD. The pentose phosphate pathway in health and disease. Nat Metab. 2023;5:1275–89.

Article  CAS  PubMed  Google Scholar 

Artyomov MN, Van den Bossche J. Immunometabolism in the Single-Cell Era. Cell Metab. 2020;32:710–25.

Article  CAS 

Comments (0)

No login
gif