Erosive Hand Osteoarthritis: Recent Advances and Future Treatments

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•• Styrkarsdottir U, Stefansdottir L, Thorleifsson G, Stefansson OA, Saevarsdottir S, Lund SH, et al. Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect. Ann Rheum Dis. 2023;82:873–80. This is the first genome-wide association study of EHOA. Four common sequence variants associated with EHOA were identified and the associated genes could be causal.

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• Oliviero F, Ramonda R, Scanu A, Galozzi P, Favero M, Punzi L. Levels of inflammatory cytokines and metalloproteinases are increased in knee synovial fluid of patients with concomitant erosive hand osteoarthritis. Clin Exp Rheumatol. 2020;38:800. This study is the first to show that levels of inflammatory biomarkers are elevated in the knees of patients with EHOA, suggesting that the more aggressive inflammatory nature of EHOA is not just limited to hand joints.

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Allado E, Wittoek R, Ferrero S, Albuisson E, Chary-Valckenaere I, Roux C, et al. Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score. PLoS ONE. 2020;15:e0234972.

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• Obotiba AD, Swain S, Kaur J, Yaseen K, Doherty M, Zhang W, et al. Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies. Osteoarthritis Cartilage. 2021;29:946–55. This study showed that inflammatory features identified by ultrasound and MRI are associated with development of erosive lesions. These advanced imaging techniques could help identify patients at risk of adverse outcomes.

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