Dengue virus pathogenesis and host molecular machineries

Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Prim. 2016;2:1–26. https://doi.org/10.1038/nrdp.2016.55.

Article  Google Scholar 

Tuiskunen Bäck A, Lundkvist Å. Dengue viruses – an overview. Infect Ecol Epidemiol. 2013;3(1):19839.

Google Scholar 

Perera R, Kuhn RJ. Structural proteomics of dengue virus. Curr Opin Microbiol. 2008;11(4):369–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Byk LA, Gamarnik AV. Properties and functions of the dengue virus capsid protein. Annu Rev Virol. 2016;3:263–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Libraty DH, Young PR, Pickering D, Endy TP, Kalayanarooj S, Green S, et al. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J Infect Dis. 2002;186(8):1165–8.

Article  CAS  PubMed  Google Scholar 

Bhatt P, Sabeena SP, Varma M, Arunkumar G. Current understanding of the pathogenesis of dengue virus infection. Curr Microbiol. 2021;78(1):17–32. https://doi.org/10.1007/s00284-020-02284-w.

Article  CAS  PubMed  Google Scholar 

Gutsche I, Coulibaly F, Voss JE, Salmon J, D’Alayer J, Ermonval M, et al. Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein. Proc Natl Acad Sci U S A. 2011;108(19):8003–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Modhiran N, Watterson D, Muller DA, Panetta AK, Sester DP, Liu L, et al. Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Sci Transl Med. 2015;7:304.

Article  Google Scholar 

Lee WHK, Liu W, Fan JS, Yang D. Dengue virus protease activity modulated by dynamics of protease cofactor. Biophys J. 2021;120(12):2444–53. https://doi.org/10.1016/j.bpj.2021.04.015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McLean JE, Wudzinska A, Datan E, Quaglino D, Zakeri Z. Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. J Biol Chem. 2011;286(25):22147–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henderson BR, Saeedi BJ, Campagnola G, Geiss BJ. Analysis of RNA binding by the dengue virus NS5 RNA capping enzyme. PLoS One. 2011;6(10):1–9.

Article  Google Scholar 

Tay MYF, Fraser JE, Chan WKK, Moreland NJ, Rathore AP, Wang C, et al. Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin. Antiviral Res. 2013;99(3):301–6. https://doi.org/10.1016/j.antiviral.2013.06.002.

Article  CAS  PubMed  Google Scholar 

Bressanelli S, Stiasny K, Allison SL, Stura EA, Duquerroy S, Lescar J, et al. Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. EMBO J. 2004;23(4):728–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504–7. https://doi.org/10.1038/nature12060.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dwivedi VD, Tripathi IP, Tripathi RC, Bharadwaj S, Mishra SK. Genomics, proteomics and evolution of dengue virus. Brief Funct Genomics. 2017;16(4):217–27.

CAS  PubMed  Google Scholar 

Madhry D, Pandey KK, Kaur J, Rawat Y, Sapra L, Kumar RYS, et al. Role of non-coding RNAs in dengue virus-host interaction. Front Biosci Sch. 2021;13(1):44–55.

Article  CAS  Google Scholar 

Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Nathan MB, et al. Europe PMC Funders Group Dengue: a continuing global threat Europe PMC Funders Author Manuscripts. Nat Rev Microbiol. 2010;8(12):7–16.

Article  Google Scholar 

Muller DA, Young PR. The flavivirus NS1 protein: molecular and structural biology, immunology, role inpathogenesis and application asadiagnostic biomarker. Antiviral Res. 2013;98(2):192–208. https://doi.org/10.1016/j.antiviral.2013.03.008.

Article  CAS  PubMed  Google Scholar 

Murphy BR, Whitehead SS. Immune response to dengue virus and prospects for a vaccine. Annu Rev Immunol. 2011;29:587–619.

Article  CAS  PubMed  Google Scholar 

Yacoub S, Mongkolsapaya J, Screaton G. The pathogenesis of dengue. Curr Opin Infect Dis. 2013;26(3):284–9.

Article  CAS  PubMed  Google Scholar 

Roy SK, Bhattacharjee S. Dengue virus: epidemiology, biology, and disease aetiology. Can J Microbiol. 2021;67(10):687–702.

Article  CAS  PubMed  Google Scholar 

Wong JM, Adams LE, Durbin AP, Muñoz-Jordán JL, Poehling KA, Sánchez-González LM, et al. Dengue: a growing problem with new interventions. Pediatrics. 2022;149(6):e2021055522.

Article  PubMed  Google Scholar 

Diamond MS, Pierson TC. Molecular insight into dengue virus pathogenesis and its implications for disease control. Cell. 2015;162(3):488–92. https://doi.org/10.1016/j.cell.2015.07.005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simmons CP, McPherson K, Van Vinh CN, Hoai Tam DT, Young P, Mackenzie J, et al. Recent advances in dengue pathogenesis and clinical management. Vaccine. 2015;33(50):7061–8.

Article  CAS  PubMed  Google Scholar 

Yong YK, Wong WF, Vignesh R, Chattopadhyay I, Velu V, Tan HY, et al. Dengue infection - recent advances in disease pathogenesis in the era of COVID-19. Front Immunol. 2022;13(July):1–17.

Google Scholar 

Palanichamy Kala M, St. John AL, Rathore APS. Dengue: update on clinically relevant therapeutic strategies and vaccines. Curr Treat Options Infect Dis. 2023;15(2):27–52. https://doi.org/10.1007/s40506-023-00263-w.

Article  PubMed  PubMed Central  Google Scholar 

Rothman AL. Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nat Rev Immunol. 2011;11(8):532–43.

Article  CAS  PubMed  Google Scholar 

Dinakaran D, Sreeraj VS, Venkatasubramanian G. Dengue and psychiatry: manifestations, mechanisms, and management options. Indian J Psychol Med. 2022;44(5):429–35.

Article  PubMed  Google Scholar 

Wang X, Xia H, Liu S, Cao L, You F. Epigenetic regulation in antiviral innate immunity. Eur J Immunol. 2021;51(7):1641–51.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Guo J, Gao Y, Li S, Pan T, Xu G, et al. Dynamic transcriptome analyses reveal m6A regulated immune non-coding RNAs during dengue disease progression. Heliyon. 2023;9(1):e12690.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gokhale NS, McIntyre ABR, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, et al. N6-methyladenosine in flaviviridae viral RNA genomes regulates infection. Cell Host Microbe. 2016;20(5):654–65. https://doi.org/10.1016/j.chom.2016.09.015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruggieri A, Helm M, Chatel-Chaix L. An epigenetic ‘extreme makeover’: the methylation of flaviviral RNA (and beyond). RNA Biol. 2021;18(5):696–708. https://doi.org/10.1080/15476286.2020.1868150.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henry BA, Kanarek JP, Kotter A, Helm M, Lee N. 5-Methylcytosine modification of an Epstein-Barr virus noncoding RNA decreases its stability. RNA. 2020;26(8):1038–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Courtney DG, Chalem A, Bogerd HP, Law BA, Kennedy EM, Holley CL, et al. Extensive epitranscriptomic methylation of A and C residues on murine leukemia virus transcripts enhances viral gene expression. MBio. 2019;10(3):1–12.

Article  Google Scholar 

Caraballo GI, Rosales R, Viettri M, Castillo JM, Cruz R, Ding S, et al. The dengue virus nonstructural protein 1 (NS1) interacts with the putative epigenetic regulator DIDO1 to promote flavivirus replication in mosquito cells. J Virol. 2022;96(12):1–17.

Article  Google Scholar 

Colpitts TM, Barthel S, Wang P, Fikrig E. Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. PLoS One. 2011;6(9):e24365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerjee A, Tripathi A, Duggal S, Banerjee A, Vrati S. Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1. Sci Rep. 2020;10(1):1–12. https://doi.org/10.1038/s41598-020-76350-5.

Article 

Comments (0)

No login
gif