Mechanism of Smilax china L. in the treatment of intrauterine adhesions based on network pharmacology, molecular docking and experimental validation

Xia S, Wu M, Zhou X, Zhang XYL, Zhang K, et al. Treating intrauterine adhesion using conditionally reprogrammed physiological endometrial epithelial cells. Stem Cell Res Ther. 2022;13:178.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L, Yang H,Guo Y, Yang G, Chen Y. The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study. Fertil Steril. 2019;111:1002–1010e1002.

Article  PubMed  Google Scholar 

Santamaria X, Isaacson K, Simón C. Asherman’s syndrome: it may not be all our fault. Hum Reprod. 2018;33:1374–80.

Article  PubMed  Google Scholar 

Ebrahim N, Mostafa O, El Dosoky RE, Ahmed IA, Saad AS, Mostafa A, et al. Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model. Stem Cell Res Ther. 2018;9:175.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pompermaier L, Marzocco S, Adesso S, Monizi M, Schwaiger S, Neinhuis C, et al. Medicinal plants of northern Angola and their anti-inflammatory properties. J Ethnopharmacol. 2018;216:26–36.

Article  PubMed  Google Scholar 

Salazar CA, Isaacson K, Morris S. A comprehensive review of Asherman’s syndrome: causes, symptoms and treatment options. Curr Opin Obstet Gynecol. 2017;29:249–56.

Article  PubMed  Google Scholar 

Touboul C, Fernandez H, Deffieux X, Berry R, Frydman R, Gervaise A. Uterine synechiae after bipolar hysteroscopic resection of submucosal myomas in patients with infertility. Fertil Steril. 2009;92:1690–3.

Article  PubMed  Google Scholar 

Siferih M, Gebre T, Hunduma F, Abebe A,Gebremichael A, Sewunet H, et al. Review of Asherman syndrome and its hysteroscopic treatment outcomes: experience in a low-resource setting. BMC Womens Health. 2024;24:99.

Article  PubMed  PubMed Central  Google Scholar 

Xu B, Zhou MLM, Wang ZDJ, Li W, et al. Bioactive Injectable and Self-Healing Hydrogel Via Cell-Free Fat Extract for Endometrial Regeneration. Small (Weinheim an Der Bergstrasse. Germany). 2023;19:e2300481.

Google Scholar 

Hua Q, Zhang Y, Li H, Li L, et al. Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17/Treg balance through NF-κB signaling in rabbit intrauterine adhesions endometrium. Stem Cell Res Ther. 2022;13:301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanwal L, Ali S, Rasul A, Tahir HM. Smilax china root extract as a novel Glucose- 6-phosphate dehydrogenase inhibitor for the treatment of hepatocellular carcinoma. Saudi J Biol Sci. 2022;29:103400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boby N, Lee E-B, Abbas MA, Park N-H, Lee S-P, Ali MS et al. Ethanol-Induced Hepatotoxicity and Alcohol Metabolism Regulation by GABA-Enriched Fermented Smilax china Root Extract in Rats. Foods; 2021.https://doi.org/10.3390/foods10102381.

Mohamed Amer MI, Omar OH, El Sherbiny Hamed M, Dahroug EG. Subendometrial blood flow changes by 3-dimensional power doppler ultrasound after hysteroscopic lysis of severe intrauterine adhesions: preliminary study. J Minim Invasive Gynecol. 2015;22:495–500.

Article  PubMed  Google Scholar 

Li X, Chu L, Liu S, Zhang W, Lin L, Zheng G. Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice. Phytomedicine. 2022;95:153728.

Article  CAS  PubMed  Google Scholar 

Tettey CO, Yang IJ, Shin HM. Endothelium-dependent vasodilatory effect of Smilax china Linn. Water extract via PI3K/Akt signaling. Arch Physiol Biochem. 2020;126:209–13.

Article  CAS  PubMed  Google Scholar 

Song L, Tian L,Ma Y,Xie Y, Feng H, Qin F, et al. Protection of flavonoids from Smilax china L. Rhizome on phenol mucilage-induced pelvic inflammation in rats by attenuating inflammation and fibrosis. J Funct Foods. 2017;28:194–204.

Article  CAS  Google Scholar 

Zhang Y, Zhao Z,Chen H, Wang W, Li Q, et al. The underlying molecular mechanisms involved in traditional Chinese medicine Smilax china L. for the treatment of pelvic inflammatory disease. Evid Based Complement Alternat Med. 2021;2021:5552532.

PubMed  PubMed Central  Google Scholar 

Zhang LJ, Zhu JY, Sun M Y,Song Y N,Rahman K, Peng C, et al. Anti-inflammatory effect of Man-Pen-Fang, a Chinese herbal compound, on chronic pelvic inflammation in rats. J Ethnopharmacol. 2017;208:57–65.

Article  PubMed  Google Scholar 

Raman K, Damaraju N, Joshi GK. The organisational structure of protein networks: revisiting the centrality-lethality hypothesis. Syst Synth Biol. 2014;8:73–81.

Article  PubMed  Google Scholar 

Tang Y, Li MWJ, Pan Y, Wu FX. CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks. BioSystems. 2015;127:67–72.

Article  CAS  PubMed  Google Scholar 

Wang Y, Yuan Y,Wang W,He Y, Zhong H, Zhou X, et al. Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking. Comput Biol Med. 2022;145:105454.

Article  CAS  PubMed  Google Scholar 

Zhao J, Wang J, Liu J, Li S, Liu P, Zhang X. Effect and mechanisms of kaempferol against endometriosis based on network pharmacology and in vitro experiments. BMC Complement Med Ther. 2022;22:254.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Çil N, Yaka MÜnalMS, Dodurga Y, Tan S,Seçme M, et al. Adipose derived mesenchymal stem cell treatment in experimental asherman syndrome induced rats. Mol Biol Rep. 2020;47:4541–52.

Article  PubMed  Google Scholar 

Ozyurt R, Celik N,Suleyman Z, Cagiran F,Kali Z, Gurkan N, et al. Fertility protective effect of taxifolin in cisplatin-induced ovarian damage. Eur Rev Med Pharmacol Sci. 2022;26:7195–203.

CAS  PubMed  Google Scholar 

Sun XH, Zhang H, Fan XP, Wang ZH. Astilbin protects against Carbon Tetrachloride-Induced Liver fibrosis in rats. Pharmacology. 2021;106:323–31.

Article  CAS  PubMed  Google Scholar 

Chen C, Sun S, Zhao J, Wu Q, He W, Sun W. Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling. Phytomedicine. 2023;108:154546.

Article  CAS  PubMed  Google Scholar 

Lu G, Zhang J, Liu X, Liu W,Cao G, Lv C, et al. Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis. J Cell Mol Med. 2019;23:6720–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong L, Miao Z,Zhang L, Shi B,Xiao Z, Qiu P, et al. Pharmacokinetics and pharmacodynamics of bioactive compounds in Penyanqing preparation in THP-1 inflammatory cells induced by Lipopolysaccharide. BMC Complement Med Ther. 2022;22:323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Z, Wang H, Zhang X, Song MYS, Jiang P, et al. Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions. Autophagy. 2022;18:2427–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Lin X,Dai Y,Hu X,Zhu H, Jiang Y, et al. Endometrial stem cells repair injured endometrium and induce angiogenesis via AKT and ERK pathways. Reproduction. 2016;152:389–402.

Article  CAS  PubMed  Google Scholar 

Hao X, Zhang S, Li PHJ, Yuan Z, Tan J. Amniotic membrane extract-enriched hydrogel augments the therapeutic effect of menstrual blood-derived stromal cells in a rat model of intrauterine adhesion. Biomater Adv. 2022;142:213165.

Article  CAS  PubMed  Google Scholar 

Li C, Wang WSS, Xu Y, Fang Z, Cong L. Expression and potential role of MMP-9 in Intrauterine Adhesion. Mediators Inflamm. 2021;2021:6676510.

Article  PubMed  PubMed Central  Google Scholar 

Wang M, Zhao J, Zhang N, Chen J. Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice. Biomed Pharmacother. 2016;83:975–88.

Article  CAS  PubMed  Google Scholar 

Wang SW, Xu Y, Weng Y Y,Fan X Y,Bai Y F,Zheng XY, et al. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food Chem Toxicol. 2018;114:227–36.

Article  CAS  PubMed  Google Scholar 

Xin C, Guangliang S, Qing Z,Qingqing L,Hang Y, Yiming Z, et al. Astilbin protects chicken peripheral blood lymphocytes from cadmium-induced necroptosis via oxidative stress and the PI3K/Akt pathway. Ecotoxicol Environ Saf. 2020;190:110064.

Article  CAS  PubMed  Google Scholar 

Healy MW, Schexnayder B, Connell MT, Terry N,DeCherney A H,Csokmay JM, et al. Intrauterine adhesion prevention after hysteroscopy: a systematic review and meta-analysis. Am J Obstet Gynecol. 2016;215:267–275e267.

Article  PubMed  Google Scholar 

Xin L, Wei C,Tong X,Dai Y,Huang D, Chen J, et al. In situ delivery of apoptotic bodies derived from mesenchymal stem cells via a hyaluronic acid hydrogel: a therapy for intrauterine adhesions. Bioact Mater. 2022;12:107–19.

CAS  PubMed 

Comments (0)

No login
gif