GlaxoSmithKline. OJJAARA (momelotinib): US prescribing information 2023. https://ojjaara.com/. Accessed 19 Sep 2023.
Ikeda K, Ueda K. Gaining MOMENTUM against anaemic myelofibrosis. Lancet. 2023;401(10373):248–9.
Passamonti F, Mora B. Myelofibrosis. Blood. 2023;141(16):1954–70.
Article CAS PubMed Google Scholar
Bassiony S, Harrison CN, McLornan DP. Evaluating the safety, efficacy, and therapeutic potential of momelotinib in the treatment of intermediate/high-risk myelofibrosis: evidence to date. Ther Clin Risk Manag. 2020;16:889–901.
Article CAS PubMed PubMed Central Google Scholar
Verstovsek S, Chen CC, Egyed M, et al. MOMENTUM: momelotinib vs danazol in patients with myelofibrosis previously treated with JAKi who are symptomatic and anemic. Future Oncol. 2021;17(12):1449–58.
Article CAS PubMed Google Scholar
Chifotides HT, Bose P, Verstovsek S. Momelotinib: an emerging treatment for myelofibrosis patients with anemia. J Hematol Oncol. 2022;15(1):7.
Article CAS PubMed PubMed Central Google Scholar
Passamonti F, Harrison CN, Mesa RA, et al. Anemia in myelofibrosis: current and emerging treatment options. Crit Rev Oncol Hematol. 2022;180: 103862.
GlaxoSmithKline. Ojjaara (momelotinib) approved in the US as the first and only treatment indicated for myelofibrosis patients with anaemia [media release]. 15 Sep 2023. https://www.gsk.com/.
European Medicines Agency. CHMP summary of positive opinion for Omjjara (momelotinib). 2023. https://www.ema.europa.eu/en/documents/smop-initial/chmp-summary-positive-opinion-omjjara_en.pdf. Accessed 14 Oct 2023.
GlaxoSmithKline. GSK regulatory submission for momelotinib for the treatment of myelofibrosis accepted for review by Japanese regulator [media release]. 11 Sep 2023. https://www.gsk.com/.
GlaxoSmithKline. GSK completes acquisition of Sierra Oncology [media release]. 1 Jul 2022. http://www.gsk.com.
Sierra Oncology Inc. Sierra Oncology acquires momelotinib, an investigational Janus kinase (JAK) 1/2 and activin receptor type 1 (ACVR1) inhibitor for myelofibrosis, from Gilead Sciences [media release]. 22 Aug 2018. https://www.prnewswire.com/news-releases/sierra-oncology-acquires-momelotinib-an-investigational-janus-kinase-jak-12-and-activin-receptor-type-1-acvr1-inhibitor-for-myelofibrosis-from-gilead-sciences-300700644.html.
Gilead Sciences Inc. Gilead Sciences completes acquisition of YM BioSciences [media release]. 8 Feb 2013. https://www.gilead.com.
YM BioSciences Inc. YM BioSciences completes merger with Cytopia [media release]. 1 Feb 2010. https://www.prnewswire.com/news-releases/ym-biosciences-completes-merger-with-cytopia-83235132.html.
Asshoff M, Petzer V, Warr MR, et al. Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents. Blood. 2017;129(13):1823–30.
Article CAS PubMed PubMed Central Google Scholar
Zheng J, Xin Y, Zhang J, et al. Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018;46(3):237–47.
Article CAS PubMed Google Scholar
Oh ST, Talpaz M, Gerds AT, et al. ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial. Blood Adv. 2020;4(18):4282–91.
Article CAS PubMed PubMed Central Google Scholar
Pardanani A, Laborde RR, Lasho TL, et al. Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis. Leukemia. 2013;27(6):1322–7.
Article CAS PubMed PubMed Central Google Scholar
Xin Y, Shao L, Maltzman J, et al. The relative bioavailability, food effect, and drug interaction with omeprazole of momelotinib tablet formulation in healthy subjects. Clin Pharmacol Drug Dev. 2018;7(3):277–86.
Article CAS PubMed Google Scholar
Xin Y, Kawashima J, Weng W, et al. Pharmacokinetics and safety of momelotinib in subjects with hepatic or renal impairment. J Clin Pharmacol. 2018;58(4):522–32.
Article CAS PubMed Google Scholar
Verstovsek S, Gerds AT, Vannucchi AM, et al. Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study. Lancet. 2023;401(10373):269–80.
Article CAS PubMed Google Scholar
Gerds AT, Verstovsek S, Vannucchi AM, et al. Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis previously treated with a JAK inhibitor (MOMENTUM): an updated analysis of an international, double-blind, randomised phase 3 study. Lancet Haematol. 2023;10(9):e735–46.
Article CAS PubMed Google Scholar
Mesa RA, Kiladjian JJ, Catalano JV, et al. SIMPLIFY-1: a phase III randomized trial of momelotinib versus ruxolitinib in Janus kinase inhibitor-naïve patients with myelofibrosis. J Clin Oncol. 2017;35(34):3844–50.
Article CAS PubMed PubMed Central Google Scholar
Gupta V, Oh S, Devos T, et al. Clinical outcomes with momelotinib vs ruxolitinib in patients with myelofibrosis and anemia: subgroup analysis of SIMPLIFY-1 [abstract no. MPN-551]. Clin Lymphoma Myeloma Leuk. 2023;23(Suppl 1):S402–3.
Harrison CN, Vannucchi AM, Platzbecker U, et al. Momelotinib versus best available therapy in patients with myelofibrosis previously treated with ruxolitinib (SIMPLIFY 2): a randomised, open-label, phase 3 trial. Lancet Haematol. 2018;5(2):e73–81.
Comments (0)