Armsby AJ, Bombard Y, Garrison NA, Halpern-Felsher BL, Ormond KE (2019) Attitudes of members of genetics professional societies toward human gene editing. CRISPR J 2(5):331. https://doi.org/10.1089/CRISPR.2019.0020
Article PubMed PubMed Central Google Scholar
Buchholzer M, Frommer WB (2023) An increasing number of countries regulate genome editing in crops. New Phytol 237(1):12–15. https://doi.org/10.1111/NPH.18333
Claiborne A, English R, Kahn J (2016) Mitochondrial replacement techniques: ethical, social, and policy considerations. Washington, DC, The National Academic Press. https://doi.org/10.17226/21871
ClinicalTrials (2023) Search for: Gene Therapy | Card Results | ClinicalTrials.Gov. https://clinicaltrials.gov/search?cond=Gene%20Therapy. Accessed 24 Oct 2023
Coller BS (2019) Ethics of human genome editing. Annual Rev Med 70:289–305. https://doi.org/10.1146/Annurev-Med-112717-094629
Critchley C, Nicol D, Bruce G, Walshe J, Treleaven T, Tuch B (2019) Predicting public attitudes toward gene editing of germlines: the impact of moral and hereditary concern in human and animal applications. Front Genet 10(JAN):704. https://doi.org/10.3389/FGENE.2018.00704/BIBTEX
Delhove J, Osenk I, Prichard I, Donnelley M (2020) Public acceptability of gene therapy and gene editing for human use: a systematic review. Hum Gene Ther 31(1–2):20–46. https://doi.org/10.1089/HUM.2019.197
Dickler HB, Collier E (1994) Gene therapy in the treatment of disease. J Allergy Clin Immunol 94(6):942–951. https://doi.org/10.1016/0091-6749(94)90111-2
Doudna JA, Charpentier E (2014) The new frontier of genome engineering with CRISPR-Cas9. Science 346:1258096. https://doi.org/10.1126/SCIENCE.1258096
Ekechi-Agwu CA, Nwafor AO (2020) Regulating assisted reproductive technologies (ART) in Nigeria: lessons from Australia and the United Kingdom. Afr J Reprod Health 24(4):82–93. https://doi.org/10.29063/AJRH2020/V24I4.9
Funk C, Kennedy B, Sciupac EP (2016) U.S. public wary about use of biomedical technology for human enhancement. Pew Research Center. https://www.pewresearch.org/science/2016/07/26/u-s-public-wary-ofbiomedical-technologies-to-enhance-human-abilities/. Accessed 24 Oct 2023
Geuverink W, van El C, Cornel M, Lietaert Peerbolte BJ, Gitsels J, Martin L (2023) Between desire and fear: a qualitative interview study exploring the perspectives of carriers of a genetic condition on human genome editing. Humanit Soc Sci Commun 10:477. https://doi.org/10.1057/S41599-023-01935-0
Hariharan S, Jonnalagadda R, Walrond E, Moseley H (2006) Knowledge, attitudes and practice of healthcare ethics and law among doctors and nurses in Barbados. BMC Med Ethics 7:7. https://doi.org/10.1186/1472-6939-7-7
Hendriks S, Giesbertz NAA, Bredenoord AL, Repping S (2018) Reasons for being in favour of or against genome modification: a survey of the Dutch general public. Hum Reprod Open 2018(3):hoy008. https://doi.org/10.1093/HROPEN/HOY008
Holdren JP, Sunstein CR, Siddiqui IA (2011) Principles for regulation and oversight of emerging technologies. Obama White House Archives. https://obamawhitehouse.archives.gov/sites/default/files/omb/inforeg/foragencies/Principles-for-Regulation-and-Oversight-of-Emerging-Technologies-new.pdf. Accessed 24 Oct 2023
Houtman D, Geuverink W, Helmrich IRAR, Vijlbrief B, Cornel M, Riedijk S (2023) “What if” should precede “whether” and “how” in the social conversation around human germline gene editing. J Community Genet 14(4):371–375. https://doi.org/10.1007/S12687-023-00652-0/FIGURES/1
Article PubMed PubMed Central Google Scholar
Hudson J, Orviska M (2011) European attitudes to gene therapy and pharmacogenetics. Drug Discov Today 16(19–20):843–847. https://doi.org/10.1016/J.DRUDIS.2011.06.008
Idoko-Akoh A, Goldhill DH, Sheppard CM, Bialy D, Quantrill JL, Sukhova K, Brown JC, Richardson S, Campbell C, Taylor L, Sherman A, Nazki S, Long JS, Skinner MA, Shelton H, Sang HM, Barclay WS, McGrew MJ (2023) Creating resistance to avian influenza infection through genome editing of the ANP32 gene family. Nature Commun 14(1):1–15. https://doi.org/10.1038/s41467-023-41476-3
Izzah SN, Setyanto D, Hasanatuludhhiyah N, Indiastuti DN, Nasution Z, D’Arqom A (2021) Attitudes of Indonesian medical doctors and medical students toward genome editing. J Multidiscip Healthc 14:1017–1027. https://doi.org/10.2147/JMDH.S303881
Article PubMed PubMed Central Google Scholar
Jasanoff S, Hurlbut J, Saha K (2015) Crispr democracy: gene editing and the need for inclusive deliberation. Issues Sci Technol 32(1):25–32
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816–821. https://doi.org/10.1126/SCIENCE.1225829/SUPPL_FILE/JINEK.SM.PDF
Article CAS PubMed PubMed Central Google Scholar
Kupferschmidt K (2023) Shadowed by past, gene-editing summit looks to future. Science 379(6637):1073–1074. https://doi.org/10.1126/SCIENCE.ADH7972
Article CAS PubMed Google Scholar
McCaughey T, Sanfilippo PG, Gooden GEC, Budden DM, Fan L, Fenwick E, Rees G, MacGregor C, Si L, Chen C, Liang HH, Baldwin T, Pébay A, Hewitt AW (2016) A global social media survey of attitudes to human genome editing. Cell Stem Cell 18(5):569–572. https://doi.org/10.1016/J.STEM.2016.04.011
Article CAS PubMed Google Scholar
Miyaoka Y, Berman JR, Cooper SB, Mayerl SJ, Chan AH, Zhang B, Karlin-Neumann GA, Conklin BR (2016) Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing. Sci Rep 6(1):1–12. https://doi.org/10.1038/srep23549
Mulvihill JJ, Capps B, Joly Y, Lysaght T, Zwart HAE, Chadwick R (2017) Ethical issues of CRISPR technology and gene editing through the lens of solidarity. Br Med Bull 122(1):17–29. https://doi.org/10.1093/bmb/ldx002
Okonta PI, Ajayi R, Bamgbopa K, Ogbeche R, C.okeke C, Onwuzurigbo K (2018) Ethical issues in the practice of assisted reproductive technologies in Nigeria: empirical data from fertility practitioners. Afr J Reprod Health 22(3):51–58
Ormond KE, Mortlock DP, Scholes DT, Bombard Y, Brody LC, Faucett WA, Garrison NA, Hercher L, Isasi R, Middleton A, Musunuru K, Shriner D, Virani A, Young CE (2017) Human germline genome editing. Am J Hum Genet 101(2):167–176. https://doi.org/10.1016/J.AJHG.2017.06.012
Article CAS PubMed PubMed Central Google Scholar
Papathanasiou S, Markoulaki S, Blaine LJ, Leibowitz ML, Zhang CZ, Jaenisch R, Pellman D (2021) Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing. Nature Commun 12(1):1–7. https://doi.org/10.1038/s41467-021-26097-y
Patra S (2015) Effects of genetic engineering - the ethical and social implications. Ann Clin Lab Res 3(1):1–2. https://doi.org/10.21767/2386-5180.10005
Ranisch R, Trettenbach K, Arnason G (2023) Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic. Med Health Care Philos 26(1):21–35. https://doi.org/10.1007/S11019-022-10115-X/FIGURES/1
Reardon S (2016) Welcome to the CRISPR zoo. Nature 531(7593):160–163. https://doi.org/10.1038/531160a
Article CAS PubMed Google Scholar
Redman M, King A, Watson C, King D (2016) What is CRISPR/Cas9? Arch Dis Child Educ Pract Ed 101(4):213–215. https://doi.org/10.1136/archdischild-2016-310459
Article PubMed PubMed Central Google Scholar
Report of the House Committee on Environment and Habitat (2019) National Assembly of Nigeria. https://placng.org/i/wp-content/uploads/2019/12/Report-of-the-House-of-Reps-Committee-on-Environment-and-Habitat-on-National-Biosafety-Management-Agency-Act-Amendment-Bill-2018.pdf. Accessed 24 Oct 2023
Rothschild J (2020) Ethical considerations of gene editing and genetic selection. J Gen Fam Med 21(3):37–47. https://doi.org/10.1002/JGF2.321
Article PubMed PubMed Central Google Scholar
Scheufele DA, Krause NM, Freiling I, Brossard D (2021) What we know about effective public engagement on CRISPR and beyond. Proc Natl Acad Sci USA 118(22):e2004835117. https://doi.org/10.1073/PNAS.2004835117/ASSET/B85631BC-3F6C-4B25-8715-6874BBDD88B4/ASSETS/IMAGES/LARGE/PNAS.2004835117FIG02.JPG
Article CAS PubMed PubMed Central Google Scholar
Sharma H, Singh D, Mahant A, Sohal SK, Kesavan AK (2020) Development of mitochondrial replacement therapy: a review. Heliyon 6(9):e04643. https://doi.org/10.1016/j.heliyon.2020.e04643
Article CAS PubMed PubMed Central Google Scholar
Tachibana M, Kuno T, Yaegashi N (2018) Mitochondrial replacement therapy and assisted reproductive technology: a paradigm shift toward treatment of genetic diseases in gametes or in early embryos. Reprod Med Biol 17(4):421–433. https://doi.org/10.1002/rmb2.12230
Article PubMed PubMed Central Google Scholar
Vajen B, Ronez J, Rathje W, Heinisch L, Ebeling S, Gebhard U, Hößle C, Schlegelberger B (2021) Students’ attitudes towards somatic genome editing versus genome editing of the germline using an example of familial leukemia. J Community Genet 12(3):397–406. https://doi.org/10.1007/S12687-021-00528-1
Article PubMed PubMed Central Google Scholar
Wang J-H, Wang R, Lee JH, Iao TWU, Hu X, Wang Y-M, Tu L-L, Mou Y, Zhu W-L, He A-Y, Zhu S-Y, Cao D, Yang L, Tan X-B, Zhang Q, Liang G-L, Tang S-M, Zhou Y-D, Feng L-J, ... Liu G-S (2017) Public attitudes toward gene therapy in China. Mol Ther Methods Clin Dev 6:40–42. https://doi.org/10.1016/j.omtm.2017.05.008
Weisberg SM, Badgio D, Chatterjee A (2017) A CRISPR new world: attitudes in the public toward innovations in human genetic modification. Front Public Health 5:117. https://doi.org/10.3389/FPUBH.2017.00117/BIBTEX
Article PubMed PubMed Central Google Scholar
Wise J (2023) First baby born in the UK using mitochondrial donation therapy. BMJ 381:p1091. https://doi.org/10.1136/BMJ.P1091
Zaboikin M, Zaboikina T, Freter C, Srinivasakumar N (2017) Non-homologous end joining and homology directed DNA repair frequency of double-stranded breaks introduced by genome editing reagents. Plos One 12(1):e0169931. https://doi.org/10.1371/JOURNAL.PONE.0169931
Article PubMed PubMed Central Google Scholar
Zarghamian P, Klermund J, Cathomen T (2023) Clinical genome editing to treat sickle cell disease-A brief update. Front Med 9:1065377. https://doi.org/10.3389/FMED.2022.1065377
Zhang F, Wen Y, Guo X (2014) CRISPR/Cas9 for genome editing: progress, implications and challenges. Hum Mol Genet 23(R1):R40–R46. https://doi.org/10.1093/HMG/DDU125
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