Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4–14.

Article  CAS  PubMed  Google Scholar 

Zeng J, Chen M, Feng Q, Wan H, Wang J, Yang F, et al. The platelet-to-lymphocyte ratio predicts Diabetic Retinopathy in type 2 diabetes Mellitus. Diabetes Metabolic Syndrome and Obesity: Targets and Therapy. 2022;15:3617–26.

Article  CAS  PubMed  Google Scholar 

Syauta D, Hendarto J, Mariana N, Kusumanegara J, Faruk M. Risk factors affecting the degree of diabetic foot ulcers according to Wagner classification in diabetic foot patients. Med Clínica Práctica. 2021;4:100231.

Article  Google Scholar 

Khunkaew S, Fernandez R, Sim J. Health-related quality of life among adults living with diabetic foot ulcers: a meta-analysis. Qual Life Res. 2019;28(6):1413–27.

Article  PubMed  Google Scholar 

Edmonds M, Manu C, Vas P. The current burden of diabetic foot disease. J Clin Orthop Trauma. 2021;17:88–93.

Article  PubMed  PubMed Central  Google Scholar 

Tang WH, Zhao YN, Cheng ZX, Xu JX, Zhang Y, Liu XM. Risk factors for diabetic foot ulcers: a systematic review and meta-analysis. Vascular. 2023. 17085381231154805.

Pena G, Armstrong DG, Mills JL, Fitridge R. Pathophysiology and principles of management of the Diabetic Foot. Mechanisms of Vascular Disease: Springer; 2020. pp. 563–91.

Google Scholar 

Bolajoko EB, Mossanda KS, Adeniyi F, Akinosun O, Fasanmade A, Morapane M. Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcer. South Afr Med J. 2008;98(8):614–7.

CAS  Google Scholar 

Ghareghani O, Ghareghani S, Takhshid MA. Diagnostic values of ischemia modified albumin in diabetes-related complications: a narrative review. J Diabetes Metabolic Disorders. 2022:1–12.

Alay H, Laloglu E, Kesmez Can F. An evaluation of ischemia-modified albumin levels in the development of diabetic foot ulcer. Int J Clin Pract. 2021;75(9):e14589.

Article  CAS  PubMed  Google Scholar 

Kim K, Mahajan A, Patel K, Syed S, Acevedo-Jake AM, Kumar VA. Materials and cytokines in the Healing of Diabetic Foot Ulcers. Adv Ther. 2021;4(9):2100075.

Article  Google Scholar 

Van Asten SA, Nichols A, La Fontaine J, Bhavan K, Peters EJ, Lavery LA. The value of inflammatory markers to diagnose and monitor diabetic foot osteomyelitis. Int Wound J. 2017;14(1):40–5.

Article  PubMed  Google Scholar 

Zakariah NA, Bajuri MY, Hassan R, Ismail Z, Mansor MM, Othman H, et al. Is procalcitonin more superior to hs-CRP in the diagnosis of infection in diabetic foot ulcer? Malays J Pathol. 2020;42(1):77–84.

CAS  PubMed  Google Scholar 

Wang L, Li Q, Chen X, Wang Z. Clinical characteristics and risk factors of lower extremity amputation in patients with diabetic foot. Pakistan J Med Sci. 2022;38(8):2253–8.

Google Scholar 

Fluss R, Faraggi D, Reiser B. Estimation of the Youden Index and its associated cutoff point. Biometrical J Biometrische Z. 2005;47(4):458–72.

Article  Google Scholar 

Giurato L, Meloni M, Izzo V, Uccioli L. Osteomyelitis in diabetic foot: a comprehensive overview. World J Diabetes. 2017;8(4):135–42.

Article  PubMed  PubMed Central  Google Scholar 

Ramanujam CL, Han D, Zgonis T. Medical imaging and laboratory analysis of diagnostic accuracy in 107 consecutive hospitalized patients with diabetic foot osteomyelitis and partial foot amputations. Foot Ankle Spec. 2018;11(5):433–43.

Article  PubMed  Google Scholar 

Wang JR, Chen Z, Yang K, Yang HJ, Tao WY, Li YP, et al. Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history. Diabetol Metab Syndr. 2020;12:55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akbas EM, Demirtas L, Ozcicek A, Timuroglu A, Bakirci EM, Hamur H, et al. Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy. Int J Clin Exp Med. 2014;7(7):1794–801.

PubMed  PubMed Central  Google Scholar 

Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015;8(7):11420–7.

CAS  PubMed  PubMed Central  Google Scholar 

Liu N, Sheng J, Pan T, Wang Y. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are Associated with Lower Extremity Vascular Lesions in chinese patients with type 2 diabetes. Clin Lab. 2019;65(3).

Atak B, Aktas G, Duman TT, Erkus E, Kocak MZ, Savli H. Diabetes control could through platelet-to-lymphocyte ratio in hemograms. Revista da Associacao Medica Brasileira (1992). 2019;65(1):38–42.

Article  PubMed  Google Scholar 

Zhang K, Ding S, Lyu X, Tan Q, Wang Z. Correlation between the platelet-to-lymphocyte ratio and diabetic foot ulcer in patients with type 2 diabetes mellitus. J Clin Lab Anal. 2021;35(4):e23719.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sánchez-Rosales AI, Guadarrama-López AL, Gaona-Valle LS, Martínez-Carrillo BE, Valdés-Ramos R. The effect of dietary patterns on inflammatory biomarkers in adults with type 2 diabetes Mellitus: a systematic review and Meta-analysis of Randomized controlled trials. Nutrients. 2022;14(21).

Kim BJ, Cho SH, Cho KI, Kim HS, Heo JH, Cha TJ. The combined impact of Neutrophil-to-lymphocyte ratio and type 2 Diabetic Mellitus on significant coronary artery disease and carotid artery atherosclerosis. J Cardiovasc Ultrasound. 2016;24(2):115–22.

Article  PubMed  PubMed Central  Google Scholar 

Li X, Shen J, Lu Z, Chen M, Fang X, Wang G. High neutrophil-to-lymphocyte ratio is associated with increased carotid artery intima-media thickness in type 2 diabetes. J Diabetes Invest. 2017;8(1):101–7.

Article  CAS  Google Scholar 

Xu T, Weng Z, Pei C, Yu S, Chen Y, Guo W, et al. The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in type 2 diabetes mellitus. Medicine. 2017;96(45):e8289.

Article  PubMed  PubMed Central  Google Scholar 

Adaikalakoteswari A, Rema M, Mohan V, Balasubramanyam M. Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with type 2 diabetes and microangiopathy. Int J Biochem Cell Biol. 2007;39(9):1673–84.

Article  CAS  PubMed  Google Scholar 

Gary T, Pichler M, Belaj K, Hafner F, Gerger A, Froehlich H, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS ONE. 2013;8(7):e67688.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mineoka Y, Ishii M, Hashimoto Y, Yamashita A, Nakamura N, Fukui M. Platelet to lymphocyte ratio correlates with diabetic foot risk and foot ulcer in patients with type 2 diabetes. Endocr J. 2019;66(10):905–13.

Article  CAS  PubMed  Google Scholar 

Demirdal T, Sen P. The significance of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratio in predicting peripheral arterial disease, peripheral neuropathy, osteomyelitis and amputation in diabetic foot infection. Diabetes Res Clin Pract. 2018;144:118–25.

Article  PubMed  Google Scholar 

Yapıcı O, Berk H, Öztoprak N, Seyman D, Tahmaz A, Merdin A. Can ratio of neutrophil-to-lymphocyte count and erythrocyte sedimentation rate in diabetic foot infecti on predict osteomyelitis and/or amputation? Hematol Rep. 2017;9(1):6981.

Article  PubMed  PubMed Central  Google Scholar 

Ong E, Farran S, Salloum M, Gardner S, Giovinco N, Armstrong DG, et al. Does everything that’s counted Count? Value of inflammatory markers for following Therapy and Predicting Outcome in Diabetic Foot infection. Int J Low Extrem Wounds. 2017;16(2):104–7.

Article  PubMed  Google Scholar 

Jeandrot A, Richard J-L, Combescure C, Jourdan N, Finge S, Rodier M, et al. Serum procalcitonin and C-reactive protein concentrations to distinguish mildly infected from non-infected diabetic foot ulcers: a pilot study. Diabetologia. 2008;51:347–52.

Article  CAS  PubMed  Google Scholar 

Hadavand F, Amouzegar A, Amid H. Pro-calcitonin, erythrocyte sedimentation rate and C-reactive protein in predicting diabetic foot ulcer characteristics; a cross sectional study. Archives of Academic Emergency Medicine. 2019;7(1).

Guo Z, Yue C, Qian Q, He H, Mo Z. Factors associated with lower-extremity amputation in patients with diabetic foot ulcers in a chinese tertiary care hospital. Int Wound J. 2019;16(6):1304–13.

Article  PubMed  PubMed Central  Google Scholar