M.H. Xiong, Y. Bao, X.Z. Yang, Y.H. Zhu, J. Wang. Delivery of antibiotics with polymeric particles. Advanced Drug Delivery Reviews 78 (2014) 63–76. https://doi.org/10.1016/j.addr.2014.02.002.
M.A. Beach, U. Nayanathara, Y. Gao, C. Zhang, Y. Xiong, Y. Wang, G.K. Such. Polymeric nanoparticles for drug delivery. Chemical Reviews 124 (2024) 5505-5616. https://doi.org/10.1021/acs.chemrev.3c00705.
WHO, https://www.who.int/ (24.09.24).
N. Osman, N. Devnarain, C.A. Omolo, V. Fasiku, Y. Jaglal, T. Govender. Surface modification of nano-drug delivery systems for enhancing antibiotic delivery and activity. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 14 (2022) e1758. https://wires.onlinelibrary.wiley.com/doi/epdf/10.1002/wnan.1758.
A.B. Engin, A. Engin. Nanoantibiotics: A novel rational approach to antibiotic resistant infections. Current Drug Metabolism 20 (2019) 720-741. https://doi.org/10.2174/1389200220666190806142835.
M. Skwarczynski, S. Bashiri, Y. Yuan, Z.M. Ziora, O. Nabil, K. Masuda, I. Toth. Antimicrobial activity enhancers: Towards smart delivery of antimicrobial agents. Antibiotics 11 (2022) 412. https://doi.org/10.3390/antibiotics11030412.
M.H. Xiong, Y. Bao, X.Z. Yang, Y.H. Zhu, J. Wang. Delivery of antibiotics with polymeric particles. Advanced Drug Delivery Reviews 78 (2014) 63-76. https://doi.org/10.1016/j.addr.2014.02.002.
S. Ladhari, N.N. Vu, C. Boisvert, A. Saidi, P. Nguyen-Tri. Recent development of polyhydroxyalkanoates (PHAs)-based materials for antibacterial applications: A review. ACS Applied Bio Materials 6 (2023) 1398-1430. https://doi.org/10.1021/acsabm.3c00078.
H.L. Loo, B.H. Goh, L.H. Lee, L.H. Chuah. Application of chitosan-based nanoparticles in skin wound healing. Asian Journal of Pharmaceutical Sciences 17 (2022) 299-332. https://doi.org/10.1016/j.ajps.2022.04.001.
B. Luciano, Polyhydroxyalkanoates Based systems: the future of drug delivery and tissue engineering devices, in Bio-Based Nanomaterials: Synthesis Protocols, Mechanisms and Applications, A.K. Mishra, C.M. Hussain, Eds., Elsevier, Amsterdam, Netherlands, 2022, p. 306. https://doi.org/10.1016/B978-0-323-85148-0.00004-X.
B. Dalton, P. Bhagabati, J. De Micco, R.B. Padamati, K. O’Connor. A review on biological synthesis of the biodegradable polymers polyhydroxyalkanoates and the development of multiple applications. Catalysts 12 (2022) 319. https://doi.org/10.3390/catal12030319.
A.M. Yousefi, G.E. Wnek. Poly (hydroxyalkanoates): Emerging biopolymers in biomedical fields and packaging industries for a circular economy. Biomedical Materials and Devices 3 (2025) 19-24. https://doi.org/10.1007/s44174-024-00166-4.
Y. Zhuikova, V. Zhuikov, V. Varlamov. Biocomposite materials based on poly (3-hydroxybutyrate) and chitosan: A review. Polymers 14 (2022) 5549. https://doi.org/10.3390/polym14245549.
Z.A. Raza, S. Khalil, S. Abid. Recent progress in development and chemical modification of poly(hydroxybutyrate)-based blends for potential medical applications. International Journal of Biological Macromolecules 160 (2020) 77-100. https://doi.org/10.1016/j.ijbiomac.2020.05.114.
R. Turco, G. Santagata, I. Corrado, C. Pezzella, M. Di Serio. In vivo and post-synthesis strategies to enhance the properties of PHB-based materials: A Review. Frontiers in Bioengineering and Biotechnology 8 (2020) 619266. https://doi.org/10.3389/fbioe.2020.619266.
S.M. Ahsan, M. Thomas, K.K. Reddy, S.G. Sooraparaju, A. Asthana, I. Bhatnagar. Chitosan as biomaterial in drug delivery and tissue engineering. International Journal of Biological Macromolecules 110 (2018) 97-109. https://doi.org/10.1016/j.ijbiomac.2017.08.140.
S. Manna, A. Seth, P. Gupta, G. Nandi, R. Dutta, S. Jana, S. Jana. Chitosan derivatives as carriers for drug delivery and biomedical applications. ACS Biomaterials Science and Engineering 9 (2023) 2181-2202. https://doi.org/10.1021/acsbiomaterials.2c01297.
B. Lu, X. Lv, Y. Le. Chitosan-modified PLGA nanoparticles for control-released drug delivery. Polymers 11 (2019) 304. https://doi.org/10.3390/polym11020304.
A.E. Yassin, A.M. Albekairy, M.E. Omer, A.A. lmutairi, Y. Alotaibi, S. Althuwaini, O.A. Alaql, S.S. Almozaai, N.M. Almutiri, W. Alluhaim, R.R. Alzahrani, A.M. Alterawi, M.A. Halwani. Chitosan-coated azithromycin/ciprofloxacin-loaded polycaprolactone nanoparticles: A characterization and potency study. Nanotechnology, Science and Applications 16 (2023) 59-72. https://doi.org/10.2147/NSA.S438484.
M.G. Arafaa, H.A. Mousac, N.N. Afifid. Preparation of PLGA-chitosan based nanocarriers for enhancing antibacterial effect of ciprofloxacin in root canal infection. Drug Delivery 27 (2020) 26-39. https://doi.org/10.1080/10717544.2019.1701140.
W. Li, N. Cicek, D.B. Levin, S. Logsetty, S. Liu. Bacteria-triggered release of a potent biocide from core-shell polyhydroxyalkanoate (PHA)-based nanofibers for wound dressing applications. Journal of Biomaterials Science, Polymer Edition 31 (2020) 394-406. https://doi.org/10.1080/09205063.2019.1693882.
J.R. Xavier, S.T. Babusha, J. George, K.V. Ramana. Material properties and antimicrobial activity of polyhydroxybutyrate (PHB) films incorporated with vanillin. Applied Biochemistry and Biotechnology 176 (2015) 1498-1510. https://doi.org/10.1007/s12010-015-1660-9.
G.S. Kiran, S.A. Jackson, S. Priyadharsini, A.D.W. Dobson, J. Selvin. Synthesis of Nm-PHB (nanomelanin-polyhydroxy butyrate) nanocomposite film and its protective effect against biofilmforming multi drug resistant Staphylococcus aureus. Scientific Reports 7 (2017) 9167. https://doi.org/10.1038/s41598-017-08816-y.
P. Basnett, E. Marcello, B. Lukasiewicz, R. Nigmatullin, A. Paxinou, M.H. Ahmad, B. Gurumayum, I. Roy. Antimicrobial materials with lime oil and a poly(3-hydroxyalkanoate) produced via valorisation of sugar cane molasses. Journal of Functional Biomaterials 11 (2020) 24. https://doi.org/10.3390/jfb11020024.
O. Gherasim, A.M. Grumezescu, A. Ficai, V. Grumezescu, A.M. Holban, B. Gălățeanu, A. Hudiță. Composite P (3HB-3HV)-CS spheres for enhanced antibiotic efficiency. Polymers 13 (2021) 989. https://doi.org/10.3390/polym13060989.
G.C. Bazzo, E. Lemos-Senna, A.T.N. Pires. Poly (3-hydroxybutyrate)/chitosan/ketoprofen or piroxicam composite microparticles: preparation and controlled drug release evaluation. Carbohydrate Polymers 77 (2009) 839-844. https://doi.org/10.1016/j.carbpol.2009.03.006.
D. Silvestri, S. Wacławek, B. Sobel, R. Torres-Mendieta, V. Novotný, N.H. Nguyen, R.S. Varma. A poly (3-hydroxybutyrate) - chitosan polymer conjugate for the synthesis of safer gold nanoparticles and their applications. Green Chemistry 20 (2018) 4975-4982. https://doi.org/10.1039/C8GC02495B.
N. Zhila, G. Kalacheva, T. Volova. Fatty acid composition and polyhydroxyalkanoates production by Cupriavidus eutrophus B-10646 cells grown on different carbon sources. Process Biochemistry 50 (2015) 69-78. http://dx.doi.org/10.1016/j.procbio.2014.10.018.
T. Volova, K. Sapozhnikova, N. Zhila. Cupriavidus necator B-10646 growth and polyhydroxyalkanoates production on different plant oils. International Journal of Biological Macromolecules 164 (2020) 121-130. https://doi.org/10.1016/j.ijbiomac.2020.07.095.
A.V. Murueva, A.M. Shershneva, K.V. Abanina, S.V. Prudnikova, E.I. Shishatskaya. Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery. Drying Technology 37 (2019) 1131-1142. https://doi.org/10.1080/07373937.2018.1487451.
S. Dash, P.N. Murthy, L. Nath, P. Chowdhury. Kinetic modeling on drug release from controlled drug delivery systems. Acta Poloniae Pharmaceutica 67 (2010) 217-223. https://www.ptfarm.pl/pub/File/Acta_Poloniae/2010/3/217.pdf
S.P. Mohandas, L. Balan, J. Gopi, B.S. Anoop, R. Philip, S.S. Cubelio, I.B. Singh. Biocompatibility of polyhydroxybutyrate-co-hydroxyvalerate films generated from Bacillus cereus MCCB 281 for medical applications. International Journal of Biological Macromolecules 176 (2021) 244-252. https://doi.org/10.1016/j.ijbiomac.2021.02.006.
EN ISO 10993-4: Biological Evaluation of Medical Devices - Part 4: Selection of Tests for Interactions with Blood, IDT (2017).
S.J. Cavalieri, Manual of Antimicrobial Susceptibility Testing, American Society for Microbiology, Washington, USA, 2009, p. 236. ISBN 1-55581-349-6.
A.V. Murueva, A.M. Shershneva, E.I. Shishatskaya, T.G. Volova. Characteristics of microparticles based on resorbable polyhydroxyalkanoates loaded with antibacterial and cytostatic drugs. International Journal of Molecular Sciences 24 (2023) 14983. https://doi.org/10.3390/ijms241914983.
V. Patravale, P. Dandekar, R. Jain, Nanoparticulate drug delivery: Perspectives on the transition from laboratory to market, Woodhead Publishing Series Biomedicine, Cambridge, UK, 2012, p. 229. ISBN 978-1-908818-19-5.
S. Sreekumar, F.M. Goycoolea, B.M. Moerschbacher, G.R. Rivera-Rodriguez. Parameters influencing the size of chitosan-TPP nano- and microparticles. Scientific Reports 8 (2018) 4695. https://doi.org/10.1038/s41598-018-23064-4.
Y. Ciro, J. Rojas, M.J. Alhajj, G.A. Carabali, C.H. Salamanca. Production and characterization of chitosan - polyanion nanoparticles by polyelectrolyte complexation assisted by high-intensity sonication for the modified release of methotrexate. Pharmaceuticals 13 (2020) 11. https://doi.org/10.3390/ph13010011.
N.K. Al-Nemrawi, A.R. Okour, R.H. Dave. Surface modification of PLGA nanoparticles using chitosan: Effect of molecular weight, concentration, and degree of deacetylation. Advanced Polymeric Science and Technology 37 (2018) 3066-3075. https://onlinelibrary.wiley.com/doi/epdf/10.1002/adv.22077.
L. Baghirova, K. Tilki, A.A. Ozturk. Evaluation of cell proliferation and wound healing effects of vitamin A palmitate-loaded PLGA/chitosan-coated PLGA nanoparticles: Preparation, characterization, release, and release kinetics. ACS Omega 8 (2023) 2658-2668. https://doi.org/10.1021/acsomega.2c07232.
M. Gaur, S. Maurya, M.S. Akhtar, A.B. Yadav. Synthesis and evaluation of BSA-loaded PLGA–chitosan composite nanoparticles for the protein-based drug delivery system. ACS Omega 8 (2023) 8751-18759. https://doi.org/10.1021/acsomega.3c00738.
M. Safdari, E. Shakiba, S. Kiaie, A. Fattahi. Preparation and characterization of ceftazidime loaded electrospun silk fibroin/gelatin mat for wound dressing. Fibers and Polymers 17 (2016) 744-750. https://doi.org/10.1007/s12221-016-5822-3.
T.G. Volova, A.V. Demidenko, A.V. Murueva, A.E. Dudaev, I. Nemtsev, E.I. Shishatskaya. Biodegradable polyhydroxyalkanoates formed by 3-and 4-hydroxybutyrate monomers to produce nanomembranes suitable for drug delivery and cell culture. Technologies 11 (2023) 106. https://doi.org/10.3390/technologies11040106.
N. Kamaly, B. Yameen, J. Wu, O.C. Farokhzad. Degradable controlled-release polymers and polymeric nanoparticles: Mechanisms of controlling drug release. Chemical Reviews 116 (2016) 2602-2663. https://doi.org/10.1021/acs.chemrev.5b00346.
T. Freier, C. Kunze, C. Nischan, S. Kramer, K. Sternberg, T. Hoptu, K.P. Schmitz. In vitro and in vivo degradation studies for development of a biodegradable patch based on poly(3-hydroxybutyrate). Biomaterials 23 (2002) 2649-2657. https://doi.org/10.1016/S0142-9612(01)00405-7.
R.W. Korsmeyer, R. Gurny, E. Doelker, P. Buri, N.A. Peppas. Mechanisms of solute release from porous hydrophilic polymers. International Journal of Pharmaceutics 15 (1983) 25-35. https://doi.org/10.1016/0378-5173(83)90064-9.
N. Drozd, A. Lunkov, B. Shagdarova, A. Il’ina, V. Varlamov. New N-methylimidazole-functionalized chitosan derivatives: Hemocompatibility and antibacterial properties. Biomimetics 8 (2023) 302. https://doi.org/10.3390/biomimetics8030302.
V. Balan, L. Verestiuc. Strategies to improve chitosan hemocompatibility: A review. European Polymer Journal 53 (2014) 171-188. https://doi.org/10.1016/j.eurpolymj.2014.01.033.
Z. Fu, H. Qiu, Y. Xu, C. Tan, H. Wang. Biological effects, properties and tissue engineering applications of polyhydroxyalkanoates: A review. International Journal of Biological Macromolecules 25 (2025) 139281. https://doi.org/10.1016/j.ijbiomac.2024.139281.
E. Shishatskaya, A. Goreva, G. Kalacheva, T. Volova. Biocompatibility and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals. Journal of Biomaterials Science, Polymer Edition 22 (2011) 2185-2203. https://doi.org/10.1163/092050610X537138.
EN ISO TR 7405: Dentistry — Evaluation of Biocompatibility of Medical Devices Used in Dentistry (2018).
A.V. Murueva, A.M. Shershneva, I.V. Nemtsev, E.I. Shishatskaya, T.G. Volova. Collagen conjugation to carboxyl-modified poly (3-hydroxybutyrate) microparticles: preparation, characterization and evaluation in vitro. Journal of Polymer Research 29 (2022) 324. https://doi.org/10.1007/s10965-022-03181-5.
J. Li, S. Zhuang. Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: Current state and perspectives. European Polymer Journal 138 (2020) 109984. https://doi.org/10.1016/j.eurpolymj.2020.109984.
I. Stefanini, M. Boni, P. Silvaplana, P. Lovera, S. Pelassa, G. De Renzi, B. Mognetti. Antimicrobial resistance, an update from the ward: Increased incidence of new potential pathogens and site of infection-specific antibacterial resistances. Antibiotics 9 (2020) 631. https://doi.org/10.3390/antibiotics9090631.
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