Background: Post-burn itching is a common and distressing complication after thermal injury that can severely diminish patients' well-being. Despite its prevalence, the acute effects of itch during hospitalization and how it relates to specific burn characteristics remain insufficiently explored, particularly in non-Western populations. Methods: We conducted a cross-sectional study in 2021 at Velayat Hospital in Rasht, Iran, enrolling 268 adults who had been admitted for at least 48 hours following a burn injury. Through patient interviews and medical-record review, we gathered information on demographics; burn severity, measured by the percentage of total body surface area affected, depth of tissue damage, and anatomical location of burns; and itch parameters, measured by patient-rated intensity on a 0-10 scale, duration in days, and areas of the body affected. To assess long-term well-being, we used the ItchyQoL questionnaire, which quantifies the impact of itching on physical, emotional, and functional aspects of quality of life. We applied parametric, non-parametric comparisons and multivariable regression models to examine how itch characteristics and burn severity influenced immediate recovery and subsequent quality of life. Results: Patients who experienced itching had larger areas of skin damage, deeper tissue injuries, and longer hospital stays than those without itching. Higher itch intensity and longer itch duration both correlated with poorer scores on the ItchyQoL, indicating a greater negative impact on quality of life. In multivariable analysis, itch intensity emerged as the strongest predictor of reduced well-being, followed by duration of itching, depth of the burn injury, and percentage of body surface area burned. Moreover, the anatomical site of the burn influenced both the severity of itching and the length of hospitalization. Conclusions: The intensity and persistence of itching during the acute hospitalization period play a critical role in patients' recovery trajectories and their long-term quality of life after a burn injury. Early recognition and aggressive management of severe or prolonged itching may help to shorten hospital stays, enhance recovery, and improve overall well-being. The complete dataset, analysis code, and detailed findings are publicly accessible in our GitHub project repository. Keywords: post-burn pruritus; quality of life; burn injury; cross-sectional study; acute care

The authors have declared no competing interest.

This study was funded by Guilan University of Medical Sciences (GUMS).

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Ethics Committee of Guilan University of Medical Sciences gave ethical approval for this work with the code number IR.GUMS.REC.1401.323.

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