Inhibitory effects of carbohydrazide indole derivative on micro-blood vessel growth using ex vivo, in vivo, and in vitro assays

Aal-Aaboda M, Abu Raghif A, Hadi N (2021) Renoprotective potential of the ultra-pure lipopolysaccharide from Rhodobacter sphaeroides on acutely injured kidneys in an animal model. Arch Razi Inst 76(6):1755–1764

CAS  PubMed  PubMed Central  Google Scholar 

Abbas AH, Abbas ZH, Ridha-Salman H, Jabar HE, Abd AH (2024) The attenuated effects of topical empagliflozin on imiquimod-induced model of psoriasis in mice. J Trop Life Sci 14(3):459–468. https://doi.org/10.11594/jtls.14.03.03

Article  Google Scholar 

Abed-Mansoor A (2022) Abu-Raghif AR (2022) Attenuated effects of rivastigmine in induced cytokine storm in mice. J Emerg Med Trauma Acute Care 3:12. https://doi.org/10.5339/jemtac.2022.ismc.12

Article  Google Scholar 

Abunaila RSH, Al-Anbari LA, Abbood MS (2020) The effects of adding gonadotropin-releasing hormone antagonist on cycle characteristics and pregnancy rate in stimulated intrauterine insemination (IUI) cycle. Int J Res Pharm Sci 11(3):3053–3060

Abu Raghif AR (2016) The anti-angiogenic activity of P-hydroxy chalcone. Int J Pharm Sci Rev Res 37(1):117–121

CAS  Google Scholar 

Abu-Raghif AR, Qasim BJ, Abady AH, Sahib HB (2015a) Effects of aqueous thyme extract against cisplatin induced nephrotoxicity in rabbits. Int J Pharm Sci Rev Res 30(1):190–194

Google Scholar 

Abu-Raghif AR, Sahib HB, Hanoon MM (2015b) Anti-angiogenic activity of Zizyphus spinachristi leaves extracts. Int J Pharm Sci Rev Res 35(1):32

Google Scholar 

Abu-Raghif AR, Alkazzaz AM, Fadheel QJ (2016) A comparative study of the effect of thyme and calcium with vitamin D3 in treatment of postmenopausal women with osteoporosis. Res J Pharm, Biol Chem Sci 9(5):260–268

CAS  Google Scholar 

Adams G (2020) A beginner’s guide to RT-PCR, qPCR and RT-qPCR. Biochemist 42(3):48–53. https://doi.org/10.1042/BIO20200034

Article  CAS  Google Scholar 

Aldhalmi AK, Al-Athari AJH (2020) The association between alfacalcidol (1-alphahydroxyvitamin D3) and oxidative stress in patients with type ii diabetic nephropathy. Syst Rev Pharm 11(11):918–927. https://doi.org/10.31838/srp.2020.11.131

Article  CAS  Google Scholar 

Aldhalmi AK, Aldabbagh L, Hamad AJ, Al-Muhana SJ, Hassoun HK, Alareedh MD, Almudafer A, Jaber JH (2020) Helicobacter pylori and recent ischemic stroke: is there a relationship? Int J Pharm Res 12(4):2828–2835. https://doi.org/10.31838/ijpr/2020.12.04.390

Article  Google Scholar 

Aldhalmi AK, Al-Athari AJH, Al-Hindy HAAM (2022) Association of tumor necrosis factor-α and myeloperoxidase enzyme with severe asthma: a comparative study. Rep Biochem Mol Biol 11(2):238–245

CAS  PubMed  PubMed Central  Google Scholar 

Aldhalmi AK, Sahib HB, Hassan OM, Mahmood AAR, Tahtamouni LH (2024) Anti-angiogenic and anti-proliferative activity of 4–2-(5-bromo-1H-indol-2-carbonyl)-N-(4-methoxyphenyl) hydrazine-1-carbothioamide: ex-vivo and in vitro study. Asian Pac J Cancer Prev 25(7):2509–2513. https://doi.org/10.31557/apjcp.2024.25.7.2509

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali KH, Al-Jawad FH, Kadhim HM (2021a) The possible hepatoprotecive effects of “krill oil and silymarin against carbon tetrachloride (CCL4)-induced rats model of liver fibrosis: in vivo study.” Res J Pharm Technol 14(11):5953–5958. https://doi.org/10.52711/0974-360X.2021.01034

Article  Google Scholar 

Ali KH, Al-Jawad FH, Kadhim HM (2021b) The possible hepatoprotective effects of combination of an oral krill oil and silymarin against carbon tetrachloride (Ccl4)-induced liver fibrosis/ injury in white albino rats: histopathological, and biochemical studies. Int J Drug Deliv Technol 11(3):827–833. https://doi.org/10.25258/ijddt.11.3.29

Article  Google Scholar 

Ali ZH, Mossa HAL, Abood MS (2021c) Evaluation of Endometrial receptivity and pregnancy outcome in view of assessment of serum and follicular fluid level of CD44 following administration of hyaluronic acid to infertile women. Pharmacologyonline 3:536–544

Ali ZK, Sahib HB (2022) Antiangiogenic activity of sweet almond (Prunus dulcis) oil alone and in combination with aspirin in both in vivo and in vitro assays. Asian Pac J Cancer Prev 23(4):1405–1413. https://doi.org/10.31557/apjcp.2022.23.4.1405

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali KA, Abu-Raghif AR, Ridha-Salman H (2025) Evaluation of common topical therapeutic agents of plane warts. Arch Dermatol Res 317(1):246. https://doi.org/10.1007/s00403-024-03789-1

Aljawad FH, Hashim HM, Jasim GA, Kadhim HM, Gorgi AQ, Jawad RF (2015) Effects of atorvastatin and coenzyme Q10 on glycemic control and lipid profile in type 2 diabetic patients. Int J Pharm Sci Rev Res 34(2):183–186

CAS  Google Scholar 

Al-Bairmani RJ, Kadhim HM (2023) Evaluation of anti-aging effects of gemfibrozil on D-galactose induced aging mouse model. Int J Drug Deliv Technol 13(3):1011–1016

Google Scholar 

Al-Humadi FW, Qassim HW, Hameed AM, Al-Athari AJH, Umran BJ, Al-Saigh RJ (2024) Comparative assessment of the effects of two intrauterine systems for long-term contraception on some haematological, biochemical, and immunological markers. Rev Clin Pharmacol Pharmacokinet Int Ed 38:63–67. https://doi.org/10.61873/FMGQ9899

Article  Google Scholar 

Al-Jasani BM, Sahib HB, Al-Saad HN (2024) The anti-angiogenic potential of thiosemicarbazide derivative of captopril (8) in breast cancer cell lines. Jordan J Biol Sci 17(3):423–433. https://doi.org/10.54319/jjbs/170304

Article  Google Scholar 

Al-Ostoot FH, Sherapura A, V V, Basappa G, HK V, BT P, Khanum SA (2021) Targeting HIF-1α by newly synthesized indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression. Pharmacological Reports 73: 1328-1343. https://doi.org/10.1007/s43440-021-00266-8

Al-Wabli RI, Alsulami MA, Bukhari SI, Moubayed NMS, Al-Mutairi MS, Attia MI (2021) Design, synthesis, and antimicrobial activity of certain new indole-1,2,4 triazole conjugates. Molecules 26(8):2292. https://doi.org/10.3390/molecules26082292

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Yasiry RZ, Jawad MA, Abbood MS (2024) Association of methylenetetrahydrofolate reductase gene polymorphism C677T with oocyte number and embryo quality in Iraqi infertile women undergoing intracytoplasmic sperm injection. Al-Rafidain J Med Sci 6(1):39–45. https://doi.org/10.54133/ajms.v6i1.421

Al-Zubaidy AA, Sahib HB (2016) Hussein ZA (2016) The anti-angiogenic activity of Phoenix dactylifera seeds extracts. IJPPS 8(1):311–315

CAS  Google Scholar 

Angelova VT, Georgiev B, Pencheva T, Pajeva I, Rangelov M, Todorova N, Zheleva-Dimitrova D, Kalcheva-Yovkova E, Valkova IV, Vassilev N (2023) Design, synthesis, in silico studies and in vitro evaluation of new indole-and/or donepezil-like hybrids as multitarget-directed agents for Alzheimer’s disease. Pharmaceuticals 16(9):1194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashour EA, Alabdali AYM, Aldhalmi AK, Taha AE, Swelum AA, Abd El-Hack ME (2022) Impacts of varying dietary energy and crude protein levels on growth, carcase traits and digestibility coefficients of growing Japanese quail (Coturnix Coturnix Japonica) during the summer season. Ital J Anim Sci 21(1):1402–1410. https://doi.org/10.1080/1828051X.2022.2118625

Article  CAS  Google Scholar 

Atarbashe RK, Abu-Raghif A (2020) The therapeutic effects of ambrisentan on experimentally induced colitis in a male rat’s models. Ann Trop Med Public Health 23(4):90–99. https://doi.org/10.36295/ASRO.2020.23411

Article  Google Scholar 

Attarbashee RK, Hamodat HF, Mammdoh JK, Ridha-Salman H (2025) The Possible effect of Bosentan on the methotrexate-induced salivary gland changes in male rats: histological and Immunohistochemical study. Toxicol Res 14(1). https://doi.org/10.1093/toxres/tfaf007

Augustin HG, Koh GY (2017) Organotypic vasculature: from descriptive heterogeneity to functional pathophysiology. Science 357(6353):eaal2379. https://doi.org/10.1126/science.aal2379

Article  CAS  Google Scholar 

Bian XW, Chen JH, Jiang XF, Bai JS, Wang QL, Zhang X (2004) Angiogenesis as an immunopharmacologic target in inflammation and cancer. Int Immunopharmacol 4(12):1537–1547. https://doi.org/10.1016/j.intimp.2004.07.017

Article  CAS  PubMed  Google Scholar 

Blois MS (1958) Antioxidant determinations by the use of a stable free radical. Nature 181(4617):1199–1200. https://doi.org/10.1038/1811199a0

Article  CAS  Google Scholar 

Brown KJ, Maynes SF, Bezos A, Maguire DJ, Ford MD, Parish CR (1996) A novel in vitro assay for human angiogenesis. Lab Invest 75(4):539–555

CAS  PubMed  Google Scholar 

Carreño A, Morales-Guevara R, Cepeda-Plaza M, Páez-Hernández D, Preite M, Polanco R, Barrera B, Fuentes I, Marchant P, Fuentes JA (2024) Synthesis, physicochemical characterization, and antimicrobial evaluation of halogen-substituted non-metal pyridine Schiff bases. Molecules 29(19):4726

Article  PubMed  PubMed Central  Google Scholar 

Čėsnienė I, Čėsna V, Miškelytė D, Novickij V, Mildažienė V, Sirgedaitė-Šėžienė V (2024) Seed treatment with cold plasma and electromagnetic field: changes in antioxidant capacity of seedlings in different Picea Abies (L.) H. Karst Half-Sib Families. Plants 13(15):2021

Article  PubMed Central  Google Scholar 

Chang Y, Yuan Y, Zhang Q, Rong Y, Yang Y, Chi M, Liu Z, Zhang Y, Yu P, Teng Y (2020) Effects of an isatin derivative on tumor cell migration and angiogenesis. RSC Adv 10(2):1191–1197. https://doi.org/10.1039/C9RA08448G

Article  CAS  Google Scholar 

Choi SH, Yoo SS, Lee SY, Park JY (2022) Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer. Arch Pharmacal Res 45(4):263–279

Article  CAS  Google Scholar 

Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162(1):156–159. https://doi.org/10.1006/abio.1987.9999

Article  CAS  PubMed 

Comments (0)

No login
gif