Metabolic abnormalities, liver enzymes increased risk of gallstones: a cross-sectional study and multivariate mendelian randomization analysis

Scherber PR, Lammert F, Glanemann M (2017) Gallstones: optimal timing of treatment. J Hepatol 67:645–647

Article  PubMed  Google Scholar 

Gutt C, Schläfer S, Lammert F (2020) The treatment of gallstones. Dtsch Arztebl Int 117:148–158

PubMed  PubMed Central  Google Scholar 

Shabanzadeh DM (1897) The symptomatic outcomes of cholecystectomy for gallstones. J Clin Med 2023:12

Google Scholar 

Lammert F, Gurusamy K, Ko CW, Miquel JF, Méndez-Sánchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJ, Wang DQ (2016) Gallstones. Nat Rev Dis Primers 2:16024

Article  PubMed  Google Scholar 

Unalp-Arida A, Ruhl CE (2023) Increasing gallstones prevalence and associations with gallbladder and biliary tract mortality in the United States. Hepatology 77:1882–1895

Article  PubMed  Google Scholar 

Su Z, Gong Y, Liang Z (2020) Prevalence of gallstone in Mainland China: a meta-analysis of cross-sectional studies. Clin Res Hepatol Gastroenterol 44:e69–e71

Article  PubMed  Google Scholar 

Lim J, Wirth J, Wu K, Giovannucci E, Kraft P, Turman C, Song M, Jovani M, Chan AT, Joshi AD (2022) Obesity, adiposity, and risk of symptomatic gallstones according to genetic susceptibility. Clin Gastroenterol Hepatol 20:e1083–e1120

Article  CAS  PubMed  Google Scholar 

de Leeuw C, Savage J, Bucur IG, Heskes T, Posthuma D (2022) Understanding the assumptions underlying Mendelian randomization. Eur J Hum Genet 30(6):653–660

Article  PubMed  PubMed Central  Google Scholar 

Sanderson E (2021) Multivariable Mendelian randomization and mediation. Cold Spring Harb Perspect Med 11(2):a038984

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aerts R, Penninckx F (2003) The burden of gallstones in Europe. Aliment Pharmacol Ther 18(Suppl 3):49–53

Article  PubMed  Google Scholar 

Miquel JF, Covarrubias C, Villaroel L, Mingrone G, Greco AV, Puglielli L, Carvallo P, Marshall G, Del Pino G, Nervi F (1998) Genetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris. Gastroenterology 115:937–946

Article  CAS  PubMed  Google Scholar 

Everhart JE, Yeh F, Lee ET, Hill MC, Fabsitz R, Howard BV, Welty TK (2002) Prevalence of gallbladder disease in American Indian populations: findings from the Strong Heart Study. Hepatology 35:1507–1512

Article  PubMed  Google Scholar 

Sun H, Warren J, Yip J, Ji Y, Hao S, Han W, Ding Y (2022) Factors influencing gallstone formation: a review of the literature. Biomolecules 12:550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nie C, Yang T, Wang Z, Suolang D, Wang S, Baima K, Wei L, Ling H, Liu L, Zeng Q et al (2022) Dietary patterns and gallstone risks in Chinese adults: a cross-sectional analysis of China multi-ethnic cohort study. J Epidemiol 33:471–477

Article  PubMed  Google Scholar 

Banach B, Modrzejewski A, Juzyszyn Z, Kurzawski M, Sroczynski T, Pawlik A (2022) Association study of SLCO1B3 and ABCC3 genetic variants in gallstones. Genes (Basel) 13:512

Article  CAS  PubMed  Google Scholar 

Nie C, Li Z, Yang T, Zhong J, Liu Q, Mi F, Yu J, Pan Y, Kan H, Hong F (2023) Associations of long-term exposure to particulate matter with gallstone risks in Chinese adults: a large cross-sectional study. Ecotoxicol Environ Saf 252:114644

Article  CAS  PubMed  Google Scholar 

Qian Q, Jiang H, Cai B, Chen D, Jiang M (2022) Physical activity and risk of gallstones: a Mendelian randomization study. Front Genet 13:943353

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen JY, Hsu CT, Liu JH, Tung TH (2014) Clinical predictors of incident gallstones in a Chinese population in Taipei. Taiwan BMC Gastroenterol 14:83

Article  CAS  PubMed  Google Scholar 

Cirillo DJ, Wallace RB, Rodabough RJ, Greenland P, LaCroix AZ, Limacher MC, Larson JC (2005) Effect of estrogen therapy on gallbladder disease. JAMA 293:330–339

Article  CAS  PubMed  Google Scholar 

Galyani Moghaddam T, Fakheri H, Abdi R, Khosh Bavar Rostami F, Bari Z (2013) The incidence and outcome of pregnancy-related biliary sludge/stones and potential risk factors. Arch Iran Med. 16:12–16

PubMed  Google Scholar 

Chen LY, Qiao QH, Zhang SC, Chen YH, Chao GQ, Fang LZ (2012) Metabolic syndrome and gallstones. World J Gastroenterol 18:4215–4220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stender S, Nordestgaard BG, Tybjaerg-Hansen A (2013) Elevated body mass index as a causal risk factor for symptomatic gallstones: a Mendelian randomization study. Hepatology 58:2133–2141

Article  CAS  PubMed  Google Scholar 

Zhang M, Mao M, Zhang C, Hu F, Cui P, Li G, Shi J, Wang X, Shan X (2022) Blood lipid metabolism and the risk of gallstones: a multi-center study and meta-analysis. Lipids Health Dis 21:26

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudkowska I, Jones PJ (2008) Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstones. Nutr Rev 66:343–348

Article  PubMed  Google Scholar 

Jakulj L, Vissers MN, Tanck MW, Hutten BA, Stellaard F, Kastelein JJ, Dallinga-Thie GM (2010) ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis. J Lipid Res 51:3016–3023

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding X, Lu CY, Mei Y, Liu CA, Shi YJ (2005) Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus. Hepatobiliary Pancreat Dis Int 4:295–298

CAS  PubMed  Google Scholar 

Wang F, Wang J, Li Y, Yuan J, Yao P, Wei S, Guo H, Zhang X, Yang H, Wu T, He M (2019) Gallstones and type 2 diabetes risk: a mendelian randomization study. Hepatology 70:610–620

Article  CAS  PubMed  Google Scholar 

Arrese M, Cortés V, Barrera F, Nervi F (2018) Nonalcoholic fatty liver disease, cholesterol gallstones, and cholecystectomy: new insights on a complex relationship. Curr Opin Gastroenterol 34:90–96

Article  CAS  PubMed  Google Scholar 

Ahmed MH, Ali A (2014) Nonalcoholic fatty liver disease and cholesterol gallstones: which comes first? Scand J Gastroenterol 49:521–527

Article  CAS  PubMed  Google Scholar 

Gu S, Hu S, Wang S, Qi C, Shi C, Fan G (2023) Bidirectional association between NAFLD and gallstones: a systematic review and meta-analysis of observational studies. Expert Rev Gastroenterol Hepatol 17:283–293

Article  CAS  PubMed  Google Scholar 

Konyn P, Alshuwaykh O, Dennis BB, Cholankeril G, Ahmed A, Kim D (2023) Gallstones and its association with nonalcoholic fatty liver disease, all-cause and cause-specific mortality. Clin Gastroenterol Hepatol 21:940-948.e942

Article  CAS  PubMed  Google Scholar 

Jaruvongvanich V, Sanguankeo A, Upala S (2016) Significant association between gallstones and nonalcoholic fatty liver disease: a systematic review and meta-analysis. Dig Dis Sci 61:2389–2396

Article  PubMed  Google Scholar 

Lee YC, Wu JS, Yang YC, Chang CS, Lu FH, Chang CJ (2014) Moderate to severe, but not mild, nonalcoholic fatty liver disease associated with increased risk of gallstones. Scand J Gastroenterol 49:1001–1006

Comments (0)

No login
gif