Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15:11–20.
Younossi ZM, Blissett D, Blissett R, Henry L, Stepanova M, Younossi Y, et al. The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe. Hepatology. 2016;64:1577–86.
Angulo P. Nonalcoholic fatty liver disease. N. Engl J Med. 2002;346:1221–31.
Article PubMed CAS Google Scholar
Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A. Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr. 2014;99:535–42.
Article PubMed CAS Google Scholar
Darand M, Darabi Z, Yari Z, Saadati S, Hedayati M, Khoncheh A, et al. Nigella sativa and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: results from a randomized, double-blind, placebo-controlled, clinical trial. Complement Ther Med. 2019;44:204–9.
Mansour A, Mohajeri-Tehrani MR, Samadi M, Qorbani M, Merat S, Adibi H, et al. Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Nutr J. 2021;20:35.
Hashemian M, Merat S, Poustchi H, Jafari E, Radmard AR, Kamangar F, et al. Red meat consumption and risk of nonalcoholic fatty liver disease in a population with low meat consumption: the golestan cohort study. Am J Gastroenterol. 2021;116:1667–75.
Article PubMed PubMed Central Google Scholar
Mansour A, Mohajeri-Tehrani MR, Samadi M, Gerami H, Qorbani M, Bellissimo N, et al. Risk factors for non-alcoholic fatty liver disease-associated hepatic fibrosis in type 2 diabetes patients. Acta Diabetol. 2019;56:1199–207.
Vahid F, Hekmatdoost A, Mirmajidi S, Doaei S, Rahmani D, Faghfoori Z. Association between index of nutritional quality and nonalcoholic fatty liver disease: the role of vitamin D and B group. Am J Med Sci. 2019;358:212–8.
Goyal A, Sharma V, Upadhyay N, Gill S, Sihag M. Flax and flaxseed oil: an ancient medicine & modern functional food. J food Sci Technol. 2014;51:1633–53.
Article PubMed PubMed Central CAS Google Scholar
Yari Z, Cheraghpour M, Alavian SM, Hedayati M, Eini-Zinab H, Hekmatdoost A. The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial. Eur J Clin Nutr. 2021;75:99–111.
Article PubMed CAS Google Scholar
Yari Z, Rahimlou M, Eslamparast T, Ebrahimi-Daryani N, Poustchi H, Hekmatdoost A. Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. Int J food Sci Nutr. 2016;67:461–9.
Article PubMed CAS Google Scholar
Yari Z, Rahimlou M, Poustchi H, Hekmatdoost A. Flaxseed supplementation in metabolic syndrome management: a pilot randomized, open-labeled, controlled study. Phytother Res. 2016:1339–44.
Adlouni A, Ghalim N, Benslimane A, Lecerf JM, Saïle R. Fasting during Ramadan induces a marked increase in high-density lipoprotein cholesterol and decrease in low-density lipoprotein cholesterol. Ann Nutr Metab. 1997;41:242–9.
Article PubMed CAS Google Scholar
Weinstein DH, Twaddell WS, Raufman J-P, Philosophe B, Mindikoglu AL. SlimQuick™-associated hepatotoxicity in a woman with alpha-1 antitrypsin heterozygosity. World J Hepatol. 2012;4:154.
Article PubMed PubMed Central Google Scholar
Kord Varkaneh H, Salehi sahlabadi A, Găman MA, Rajabnia M, Sedanur Macit-Çelebi M, Santos HO, et al. Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: a randomized controlled trial. Front Nutr. 2022;9:948655.
Kord-Varkaneh H, Salehi-Sahlabadi A, Tinsley GM, Santos HO, Hekmatdoost A. Effects of time-restricted feeding (16/8) combined with a low-sugar diet on the management of non-alcoholic fatty liver disease: a randomized controlled trial. Nutrition. 2023;105:111847.
Article PubMed CAS Google Scholar
Varkaneh Kord H, M. Tinsley G, O. Santos H, Zand H, Nazary A, Fatahi S, et al. The influence of fasting and energy-restricted diets on leptin and adiponectin levels in humans: a systematic review and meta-analysis. Clin Nutr. 2021;40:1811–21.
Article PubMed CAS Google Scholar
Fatahi S, Nazary-Vannani A, Sohouli MH, Mokhtari Z, Kord-Varkaneh H, Moodi V, et al. The effect of fasting and energy restricting diets on markers of glucose and insulin controls: a systematic review and meta-analysis of randomized controlled trials. Crit Rev food Sci Nutr. 2021;61:3383–94.
Article PubMed CAS Google Scholar
De Ledinghen V, Vergniol J. Transient elastography (fibroscan). Gastroenterol Clin et Biologique. 2008;32:58–67.
Obesity NAAftSo, Heart N, Lung, Institute B, Initiative NOE. The practical guide: identification, evaluation, and treatment of overweight and obesity in adults. Clin Nurse Specialist. 2000;16:164.
Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79:727–47.
Article PubMed CAS Google Scholar
Hallal PC, Victora CG. Reliability and validity of the international physical activity questionnaire (IPAQ). Med Sci Sports Exerc. 2004;36:556.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.
Article PubMed CAS Google Scholar
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402–10.
Article PubMed CAS Google Scholar
Alhamdan B, Garcia‐Alvarez A, Alzahrnai A, Karanxha J, Stretchberry D, Contrera K, et al. Alternate‐day versus daily energy restriction diets: which is more effective for weight loss? a systematic review and meta‐analysis. Obes Sci Pract. 2016;2:293–302.
Article PubMed PubMed Central CAS Google Scholar
Astudillo C, Acevedo P, Ceballo K, Julio M, Dorfman M, Cruz G. Time restricted feeding 16/8 improves metabolic parameters and fatty liver in obese mice. Endocrine Abstracts. 2022;81:EP439.
Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 1991;54:438–63.
Article PubMed CAS Google Scholar
Wu H, Pan A, Yu Z, Qi Q, Lu L, Zhang G, et al. Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome. J Nutr. 2010;140:1937–42.
Article PubMed PubMed Central CAS Google Scholar
Patenaude A, Rodriguez-Leyva D, Edel A, Dibrov E, Dupasquier C, Austria J, et al. Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject. Eur J Clin Nutr. 2009;63:1123–9.
Article PubMed CAS Google Scholar
Webb MJ, Kauer SD, Ozer EM, Haller DM, Sanci LA. Does screening for and intervening with multiple health compromising behaviours and mental health disorders amongst young people attending primary care improve health outcomes? a systematic review. BMC Fam Pract. 2016;17:1–12.
Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutr Res. 2013;33:367–75.
Article PubMed CAS Google Scholar
Cassani RSL, Fassini PG, Silvah JH, Lima CMM, Marchini JS. Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study. Nutr J. 2015;14:1–8.
Wang X, Yang Q, Liao Q, Li M, Zhang P, Santos HO, et al. Effects of intermittent fasting diets on plasma concentrations of inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials. Nutrition. 2020;79:110974.
Yang S-F, Tseng J-K, Chang Y-Y, Chen Y-C. Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters. J Agric food Chem. 2009;57:5078–83.
Article PubMed CAS Google Scholar
Ezpeleta M, Gabel K, Cienfuegos S, Kalam F, Lin S, Pavlou V, et al. Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: a randomized controlled trial. Cell Metab. 2023;35:56–70.
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