Clinical characteristics and managements of congenital hepatic hemangioma: a cohort study of 211 cases

Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, et al. Vascular anomalies classification: recommendations from the international society for the study of vascular anomalies. Pediatrics 2015;136(1):e203-214

Article  PubMed  Google Scholar 

Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, et al. Guidance document for hepatic hemangioma (infantile and congenital) evaluation and monitoring. J Pediatr 2018;203(294–300): e292

Google Scholar 

Christison-Lagay ER, Burrows PE, Alomari A, Dubois J, Kozakewich HP, Lane TS, et al. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg 2007;42(1):62–67 (discussion 67–68)

Article  PubMed  Google Scholar 

Kulungowski AM, Alomari AI, Chawla A, Christison-Lagay ER, Fishman SJ. Lessons from a liver hemangioma registry: subtype classification. J Pediatr Surg 2012;47(1):165–170

Article  PubMed  Google Scholar 

Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, et al. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg 2009;44(1):125–133

Article  PubMed  Google Scholar 

Enjolras O, Mulliken JB, Boon LM, Wassef M, Kozakewich HP, Burrows PE. Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly. Plast Reconstr Surg 2001;107(7):1647–1654

Article  CAS  PubMed  Google Scholar 

Boon LM, Enjolras O, Mulliken JB. Congenital hemangioma: evidence of accelerated involution. J Pediatr 1996;128(3):329–335

Article  CAS  PubMed  Google Scholar 

North PE, Waner M, James CA, Mizeracki A, Frieden IJ, Mihm MC Jr. Congenital nonprogressive hemangioma: a distinct clinicopathologic entity unlike infantile hemangioma. Arch Dermatol 2001;137(12):1607–1620

Article  CAS  PubMed  Google Scholar 

Nasseri E, Piram M, McCuaig CC, Kokta V, Dubois J, Powell J. Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. J Am Acad Dermatol 2014;70(1):75–79

Article  PubMed  Google Scholar 

Delgado-Miguel C, Triana P, Miguel-Ferrero M, Diaz M, Hierro L, Jara P, et al. Mortality predictive factors in congenital hepatic hemangioma: a case-control study. Eur J Pediatr 2023;182(4):1657–1663

Article  CAS  PubMed  Google Scholar 

Rutten C, Ladarre D, Ackermann O, Gonzales E, Guettier C, Franchi-Abella S. Spontaneous evolution patterns of focal congenital hepatic hemangiomas: a case series of 25 patients. Pediatr Radiol 2022;52(6):1048–1060

Article  PubMed  Google Scholar 

Gong X, Li Y, Yang K, Chen S, Ji Y. Infantile hepatic hemangiomas: looking backwards and forwards. Precis Clin Med 2022;5(1):pbac006

Article  PubMed  PubMed Central  Google Scholar 

Macdonald A, Durkin N, Deganello A, Sellars ME, Makin E, Davenport M. Historical and contemporary management of infantile hepatic hemangioma: a 30-year single-center experience. Ann Surg 2022;275(1):e250–e255

Article  PubMed  Google Scholar 

Roebuck D, Sebire N, Lehmann E, Barnacle A. Rapidly involuting congenital haemangioma (RICH) of the liver. Pediatr Radiol 2012;42(3):308–314

Article  PubMed  Google Scholar 

Zavras N, Dimopoulou A, Machairas N, Paspala A, Vaos G. Infantile hepatic hemangioma: current state of the art, controversies, and perspectives. Eur J Pediatr 2020;179(1):1–8

Article  PubMed  Google Scholar 

Yang K, Peng S, Chen L, Chen S, Ji Y. Efficacy of propranolol treatment in infantile hepatic haemangioma. J Paediatr Child Health 2019;55(10):1194–1200

Article  PubMed  Google Scholar 

Ji Y, Chen S, Xiang B, Xu Z, Jiang X, Liu X, et al. Clinical features and management of multifocal hepatic hemangiomas in children: a retrospective study. Sci Rep 2016;6:31744

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji Y, Chen S, Yang K, Zhang X, Zhou J, Li L, et al. Efficacy and safety of propranolol vs atenolol in infants with problematic infantile hemangiomas: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg 2021;147(7):599–607

Article  PubMed  Google Scholar 

Ji Y, Chen S, Zhou J, Yang K, Zhang X, Xiang B, et al. Sirolimus plus prednisolone vs sirolimus monotherapy for kaposiform hemangioendothelioma: a randomized clinical trial. Blood 2022;139(11):1619–1630

Article  CAS  PubMed  Google Scholar 

Ji Y, Chen S, Yang K, Zhou J, Zhang X, Jiang X, et al. A prospective multicenter study of sirolimus for complicated vascular anomalies. J Vasc Surg 2021;74(5):1673-1681e1673

Article  PubMed  Google Scholar 

Lozar Krivec J, Lah N, Glusic M, Velikonja O, Paro-Panjan D. Treatment of symptomatic focal hepatic hemangioma with propranolol in neonates: is it efficient? Pediatr Gastroenterol Hepatol Nutr 2023;26(1):70–77

Article  PubMed  PubMed Central  Google Scholar 

Konanur A, Jimenez JE, Kochin M, McCormick A, Salgado C, Yilmaz S, et al. Non-involuting congenital hemangioma with delayed hypertrophy: a case series. Int J Pediatr Otorhinolaryngol 2022;157: 111102

Article  PubMed  Google Scholar 

Triana P, Rodriguez-Laguna L, Giacaman A, Salinas-Sanz JA, Martin-Santiago A, Lopez-Santamaria M, et al. Congenital hepatic hemangiomas: clinical, histologic, and genetic correlation. J Pediatr Surg 2020;55(10):2170–2176

Article  PubMed  Google Scholar 

Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, et al. Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma. Am J Hum Genet 2016;98(6):1271

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gestrich CK, Vivero MP, Konczyk DJ, Goss JA, Labow BI, Pearson GD, et al. Papillary hemangioma harbors somatic GNA11 and GNAQ mutations. Am J Surg Pathol 2023;48:106–111

Article  PubMed  Google Scholar 

Greene AK, Goss JA. Vascular anomalies: from a clinicohistologic to a genetic framework. Plast Reconstr Surg 2018;141(5):709e–717e

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rialon KL, Murillo R, Fevurly RD, Kulungowski AM, Christison-Lagay ER, Zurakowski D, et al. Risk factors for mortality in patients with multifocal and diffuse hepatic hemangiomas. J Pediatr Surg 2015;50(5):837–841

Article  PubMed  Google Scholar 

Rutten C, Ackermann O, Lambert V, Durand P, Gonzales E, Kreindel TG, et al. Pediatric hepatic hemangiomas: spectrum and prognostic significance of initial ultrasound findings. Pediatr Radiol 2023;53(12):2446–2457

Article  PubMed  Google Scholar 

Wei H, Li Y, Li L, Hu Q, Shi M, Cheng L, et al. Novel organoid construction strategy for non-involuting congenital hemangioma for drug validation. J Biol Eng 2023;17(1):32

Article  CAS  PubMed  PubMed Central  Google Scholar 

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