Simon TG, Bradley J, Jones A, et al. Massive intravascular hemolysis from Clostridium perfringens septicemia: a review. J Intensive Care Med. 2014;29:327–33.

Article  PubMed  Google Scholar 

Suzaki A, Hayakawa S. Clinical and microbiological features of fulminant haemolysis caused by Clostridium perfringens bacteraemia: unknown pathogenesis. Microorganisms. 2023;11(4):824.

Article  PubMed  PubMed Central  CAS  Google Scholar 

McArthur HL, Dalal BI, Kollmannsberger C. Intravascular hemolysis as a complication of Clostridium perfringens sepsis. J Clin Oncol. 2006;24(15):2387–8.

Article  PubMed  Google Scholar 

Navarro MA, McClane BA, Uzal FA. Mechanisms of action and cell death associated with Clostridium perfringens toxins. Toxins (Basel). 2018;10(5):212.

Article  PubMed  Google Scholar 

Suzaki A, Ohtani K, Komine-Aizawa S, Matsumoto A, Kamiya S, Hayakawa S. Pathogenic characterization of Clostridium perfringens strains isolated from patients with massive intravascular hemolysis. Front Microbiol. 2021;12: 713509.

Article  PubMed  PubMed Central  Google Scholar 

Verherstraeten S, Goossens E, Valgaeren B, Pardon B, et al. Perfringolysin O: the underrated Clostridium perfringens toxin? Toxins (Basel). 2015;7(5):1702–21.

Article  PubMed  CAS  Google Scholar 

Titball RW, Naylor CE, Basak AK. The Clostridium perfringens alpha-toxin. Anaerobe. 1999;5(2):51–64.

Article  PubMed  CAS  Google Scholar 

Minneci PC, Deans KJ, Zhi H, Yuen PS, et al. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest. 2005;115(12):3409–17.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dvanajscak Z, Walker PD, Cossey LN, Messias NC, et al. Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders. Kidney Int. 2019;96(6):1400–7.

Article  PubMed  CAS  Google Scholar 

Smit B, van der Helm MW, Bosma M, Hudig F, Russcher H. Massive hemolysis due to Clostridium perfringens: a laboratory’s perspective. Clin Chem Lab Med. 2020;58(11):e295–7.

Article  PubMed  CAS  Google Scholar 

Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293(13):1653–62.

Article  PubMed  CAS  Google Scholar 

Cobo F, Pérez-Carrasco V, Martín-Hita L, García-Salcedo JA, Navarro-Marí JM. Comparative evaluation of MALDI-TOF MS and 16S rRNA gene sequencing for the identification of clinically relevant anaerobic bacteria. Crit Eval Discrepant Result Anaerob. 2023;14(82): 102754.

Google Scholar 

Mitchell SL, Simner PJ. Next-generation sequencing in clinical microbiology: are we there yet? Clin Lab Med. 2019;39(3):405–18.

Article  PubMed  Google Scholar 

Kiu R, Hall LJ. An update on the human and animal enteric pathogen Clostridium perfringens. Emerg Microbes Infect. 2018;7(1):141.

Article  PubMed  PubMed Central  Google Scholar 

Pence MA. Antimicrobial resistance in clinically important anaerobes. Clin Microbio Newsl. 2019;41(1):1–7.

Article  Google Scholar 

Stevens DL, Maier KA, Mitten JE. Effect of antibiotics on toxin production and viability of Clostridium perfringens. Antimicrob Agent Chemother. 1987;31(2):213–8.

Article  CAS  Google Scholar 

Brook I. Treatment of anaerobic infection. Expert Rev Anti Infect Ther. 2007;5(6):991–1006.

Article  PubMed  CAS  Google Scholar 

De Rosa S, Marengo M, Fiorentino M, Fanelli V, Brienza N, Fiaccadori E, Grasselli G, Morabito S, Pota V, Romagnoli S, Valente F, Cantaluppi V. SIAARTI-SIN joint commission Extracorporeal blood purification therapies for sepsis-associated acute kidney injury in critically ill patients: expert opinion from the SIAARTI-SIN joint commission. J Nephrol. 2023. https://doi.org/10.1007/s40620-023-01637-5.

Article  PubMed  PubMed Central  Google Scholar 

Evans L, Rhodes A, Alhazzani W, Antonelli M, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensiv Care Med. 2021;47(11):1181–247.

Article  Google Scholar 

Broman ME, Hansson F, Vincent JL, Bodelsson M. Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock: a randomized crossover double-blind study. PLoS ONE. 2019;14(8): e0220444.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cucchiari D, Reverter E, Blasco M, Molina-Andujar A, et al. High cut-off membrane for in-vivo dialysis of free plasma hemoglobin in a patient with massive hemolysis. BMC Nephrol. 2018;19:250.

Article  PubMed  PubMed Central  CAS  Google Scholar