RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs

Amadio M, Bucolo C, Leggio GM, Drago F, Govoni S, Pascale A (2010) The PKCbeta/HuR/VEGF pathway in diabetic retinopathy. Biochem Pharmacol 80:1230–1237. https://doi.org/10.1016/j.bcp.2010.06.033

Article  PubMed  CAS  Google Scholar 

Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A, Jr., Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A (2021) International classification of retinopathy of prematurity, Third Edition. Ophthalmology 128:e51-e68. https://doi.org/10.1016/j.ophtha.2021.05.031

Dai C, Webster KA, Bhatt A, Tian H, Su G, Li W (2021) Concurrent physiological and pathological angiogenesis in retinopathy of prematurity and emerging therapies. Int J Mol Sci. https://doi.org/10.3390/ijms22094809

Article  PubMed  PubMed Central  Google Scholar 

Deng Y, Li S, Li S, Yu C, Huang D, Chen H, Yin X (2020) CircPDE4B inhibits retinal pathological angiogenesis via promoting degradation of HIF-1α though targeting miR-181c. IUBMB Life 72:1920–1929. https://doi.org/10.1002/iub.2307

Article  PubMed  CAS  Google Scholar 

Fevereiro-Martins M, Marques-Neves C, Guimarães H, Bicho M (2023) Retinopathy of prematurity: a review of pathophysiology and signaling pathways. Surv Ophthalmol 68:175–210. https://doi.org/10.1016/j.survophthal.2022.11.007

Article  PubMed  Google Scholar 

Fu XL, He FT, Li MH, Fu CY, Chen JZ (2023) Up-regulation of miR-192-5p inhibits the ELAVL1/PI3Kδ axis and attenuates microvascular endothelial cell proliferation, migration and angiogenesis in diabetic retinopathy. Diabet Med 40:e15077. https://doi.org/10.1111/dme.15077

Article  PubMed  CAS  Google Scholar 

Guan JT, Li XX, Peng DW, Zhang WM, Qu J, Lu F, D’Amato RJ, Chi ZL (2020) MicroRNA-18a-5p administration suppresses retinal neovascularization by targeting FGF1 and HIF1A. Front Pharmacol 11:276. https://doi.org/10.3389/fphar.2020.00276

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang C, Qi P, Cui H, Lu Q, Gao X (2022) CircFAT1 regulates retinal pigment epithelial cell pyroptosis and autophagy via mediating m6A reader protein YTHDF2 expression in diabetic retinopathy. Exp Eye Res 222:109152. https://doi.org/10.1016/j.exer.2022.109152

Article  PubMed  CAS  Google Scholar 

Huang XM, Liu Q, Xu ZY, Yang XH, Xiao F, Ouyang PW, Yi WZ, Zhao N, Meng J, Cui YH, Pan HW (2023) Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy. Exp Eye Res 227:109378. https://doi.org/10.1016/j.exer.2022.109378

Article  PubMed  CAS  Google Scholar 

Hutchins EJ, Gandhi S, Chacon J, Piacentino M, Bronner ME (2022) RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification. Elife. https://doi.org/10.7554/eLife.63600

Article  PubMed  PubMed Central  Google Scholar 

Ke X, Hu H, Peng Q, Ying H, Chu X (2023) USP33 promotes nonalcoholic fatty acid disease-associated fibrosis in gerbils via the c-myc signaling. Biochem Biophys Res Commun 669:68–76. https://doi.org/10.1016/j.bbrc.2023.05.100

Article  PubMed  CAS  Google Scholar 

Kunimi H, Lee D, Ibuki M, Katada Y, Negishi K, Tsubota K, Kurihara T (2021) Inhibition of the HIF-1α/BNIP3 pathway has a retinal neuroprotective effect. Faseb j 35:e21829. https://doi.org/10.1096/fj.202100572R

Article  PubMed  CAS  Google Scholar 

Li HY, Yuan Y, Fu YH, Wang Y, Gao XY (2020) Hypoxia-inducible factor-1α: a promising therapeutic target for vasculopathy in diabetic retinopathy. Pharmacol Res 159:104924. https://doi.org/10.1016/j.phrs.2020.104924

Article  PubMed  CAS  Google Scholar 

Ling S, Shan Q, Zhan Q, Ye Q, Liu P, Xu S, He X, Ma J, Xiang J, Jiang G, Wen X, Feng Z, Wu Y, Feng T, Xu L, Chen K, Zhang X, Wei R, Zhang C, Cen B, Xie H, Song P, Liu J, Zheng S, Xu X (2020) USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation. Gut 69:1322–1334. https://doi.org/10.1136/gutjnl-2019-319616

Article  PubMed  CAS  Google Scholar 

Long L, Li Y, Yu S, Li X, Hu Y, Long T, Wang L, Li W, Ye X, Ke Z, Xiao H (2019) Scutellarin prevents angiogenesis in diabetic retinopathy by downregulating VEGF/ERK/FAK/Src pathway signaling. J Diabetes Res 2019:4875421. https://doi.org/10.1155/2019/4875421

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lv C, Wang S, Lin L, Wang C, Zeng K, Meng Y, Sun G, Wei S, Liu Y, Zhao Y (2021) USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma. Cell Death Dis 12:803. https://doi.org/10.1038/s41419-021-04089-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Min J, Zeng T, Roux M, Lazar D, Chen L, Tudzarova S (2021) The role of HIF1α-PFKFB3 pathway in diabetic retinopathy. J Clin Endocrinol Metab 106:2505–2519. https://doi.org/10.1210/clinem/dgab362

Article  PubMed  PubMed Central  Google Scholar 

Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J (2023) USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A. Cell Death Differ 30:2393–2407. https://doi.org/10.1038/s41418-023-01228-8

Article  PubMed  CAS  Google Scholar 

Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, Li Y, Balajee AS, Zhao Y (2020) USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy. Autophagy 16:724–734. https://doi.org/10.1080/15548627.2019.1656957

Article  PubMed  CAS  Google Scholar 

Niu Y, Jiang H, Yin H, Wang F, Hu R, Hu X, Peng B, Shu Y, Li Z, Chen S, Guo F (2022) Hepatokine ERAP1 disturbs skeletal muscle insulin sensitivity via inhibiting USP33-mediated ADRB2 deubiquitination. Diabetes 71:921–933. https://doi.org/10.2337/db21-0857

Article  PubMed  CAS  Google Scholar 

Osera C, Martindale JL, Amadio M, Kim J, Yang X, Moad CA, Indig FE, Govoni S, Abdelmohsen K, Gorospe M, Pascale A (2015) Induction of VEGFA mRNA translation by CoCl2 mediated by HuR. RNA Biol 12:1121–1130. https://doi.org/10.1080/15476286.2015.1085276

Article  PubMed  PubMed Central  Google Scholar 

Rothamel K, Arcos S, Kim B, Reasoner C, Lisy S, Mukherjee N, Ascano M (2021) ELAVL1 primarily couples mRNA stability with the 3’ UTRs of interferon-stimulated genes. Cell Rep 35:109178. https://doi.org/10.1016/j.celrep.2021.109178

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sabri K, Ells AL, Lee EY, Dutta S, Vinekar A (2022) Retinopathy of prematurity: a global perspective and recent developments. Pediatrics. https://doi.org/10.1542/peds.2021-053924

Article  PubMed  Google Scholar 

Semenza GL (2001) HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 13:167–171. https://doi.org/10.1016/s0955-0674(00)00194-0

Article  PubMed  CAS  Google Scholar 

Shruthi K, Reddy SS, Reddy GB (2017) Ubiquitin-proteasome system and ER stress in the retina of diabetic rats. Arch Biochem Biophys 627:10–20. https://doi.org/10.1016/j.abb.2017.06.006

Article  PubMed  CAS  Google Scholar 

Snyder NA, Silva GM (2021) Deubiquitinating enzymes (DUBs): regulation, homeostasis, and oxidative stress response. J Biol Chem 297:101077. https://doi.org/10.1016/j.jbc.2021.101077

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sulkshane P, Duek I, Ram J, Thakur A, Reis N, Ziv T, Glickman MH (2020) Inhibition of proteasome reveals basal mitochondrial ubiquitination. J Proteomics 229:103949. https://doi.org/10.1016/j.jprot.2020.103949

Article  PubMed  CAS  Google Scholar 

Wang H, Liu Z, Sun Z, Zhou D, Mao H, Deng G (2021) Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma. Cell Cycle 20:2066–2076. https://doi.org/10.1080/15384101.2021.1970305

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