Uemura K, Shintani-Ishida K, Saka K, Nakajima M, Ikegaya H, Kikuchi Y, Yoshida KI (2008) Biochemical blood markers and sampling sites in forensic autopsy. J. Forensic Leg Med 15(5):312–317

Article  Google Scholar 

Madea B. Musshoff F (2007) Postmortem biochemistry. Forensic Sci Int 165(2–3):165–171

Article  CAS  Google Scholar 

Arroyo A, Rosel P, Marron T (2005) Cerebrospinal fluid: postmortem biochemical study. J Clin Forensic Med 12(3):153–156

Article  CAS  PubMed  Google Scholar 

Chen JH, Inamori-Kawamoto O, Michiue T, Ikeda S, Ishikawa T, Maeda H (2015) Cardiac biomarkers in blood, and pericardial and cerebrospinal fluids of forensic autopsy cases: a reassessment with special regard to postmortem interval. Leg. Med 17(5):343–350

CAS  Google Scholar 

Maeda H, Ishikawa T, Michiue T (2011) Forensic biochemistry for functional investigation of death: concept and practical application. Leg. Med 13(2):55–67

CAS  Google Scholar 

Maeda H, Zhu BL, Ishikawa T, Quan L, Michiue T (2009) Significance of postmortem biochemistry in determining the cause of death. Leg. Med 11:46–49

Google Scholar 

Luna A, Villanueva E, Castellano MA, Jimenez G (1982) The determination of CK, LDH and its isoenzymes in pericardial fluid and its application to the post-mortem diagnosis of myocardial infarction. Forensic Sci Int 19(1):85–91

CAS  Google Scholar 

Luna A (2009) Is postmortem biochemistry really useful? Why is it not widely used in forensic pathology? Leg Med 11:27–30

Google Scholar 

Belsey SL, Flanagan RJ (2016) Postmortem biochemistry: current applications. J Forensic Leg Med 41:49–57

Article  CAS  Google Scholar 

Michaud K, Augsburger M, Donzé N, Sabatasso S, Faouzi M, Bollmann M, Mangin P (2008) Evaluation of postmortem measurement of NT-proBNP as a marker for cardiac function. Int J Legal Med 122(5):415–420

Article  PubMed  Google Scholar 

Cina SJ, Chan DW, Boitnott JK, Hruban RH, Smialek JE (1998) Serum concentrations of cardiac troponin I in sudden death: a pilot study. Am J Forensic Med Pathol 19(4):324–328

Article  CAS  PubMed  Google Scholar 

Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J (2008) Harrison’s principles of internal medicine, 17th edn. McGraw-Hill, New York

Google Scholar 

Macdonald G, Medicine Harrison’sI, Fauci -byAS, Kasper DL, Longo DL, Braunwald E, Hauser SL, Jameson JL, Loscalzo J (2008) Intern Med J 38(12):932–932

Article  Google Scholar 

Sureka B, Bansal K, Arora A (2015) Pulmonary edema–cardiogenic or noncardiogenic? J Family Med Prim Care 4(2):290

Google Scholar 

Arrigo M, Parenica J, Ganovska E, Pavlusova M, Mebazaa A (2019) Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary síndrome. IJC Heart Vasculature 22:174–176

Article  PubMed  PubMed Central  Google Scholar 

Choi JJ, McCarthy MW (2018) The prognostic value of mid-regional pro-adrenomedullin in the evaluation of acute dyspnea. Expert Rev Mol Diagn 18(2):147–153 Epub 2018 Jan 19. PMID: 29319365

Article  CAS  PubMed  Google Scholar 

Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T (2021) Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-ß-Smads signaling and myofibroblast differentiation. Endocrinology 162(8):bqab090. https://doi.org/10.1210/endocr/bqab090. PMID: 33955458

Holmes D, Campbell M, Harbinson M, Bell D (2013) Protective effects of intermedin on cardiovascular, pulmonary and renal diseases: comparison with adrenomedullin and CGRP. Curr Protein Pept Sci 14(4):294–329. https://doi.org/10.2174/13892037113149990049. PMID: 23745696

Williams L, Brown T, Lee H (2021) Cortisol levels in forensic medicine: diagnostic applications. Forensic Sci J 68(2):145–159

Google Scholar 

Brown S, Green M (2018) Post-mortem cortisol stability. J Forensic Sci 63(4):786–793

Google Scholar 

Lang LM, Linnet K (2013) Postmortem urinary cortisol levels in relation to the cause of death. J Forensics Res 4(3):1–4

CAS  Google Scholar 

Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Tanaka M (2013) Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Hypertension 61(2):341–351

Article  CAS  PubMed  Google Scholar 

Bunton DC, Petrie MC, Hillier C, Johnston F, McMurray JJ (2004) The clinical relevance of adrenomedullin: a promising profile? Pharmacol. Ther 103(3):179–201

CAS  Google Scholar 

Voors AA, Kremer D, Geven C, Ter Maaten JM, Struck J, Bergmann A, Butler J (2019) Adrenomedullin in heart failure: pathophysiology and therapeutic application. Eur J Heart Fail 21(2):163–171

Article  CAS  PubMed  Google Scholar 

Molvin J, Jujic A, Navarin S, Melander O, Zoccoli G, Hartmann O, Magnusson M (2019) Bioactive adrenomedullin, proenkephalin A and clinical outcomes in an acute heart failure setting. Open Heart 6(2):e001048

Article  PubMed  PubMed Central  Google Scholar 

Ter Maaten JM, Kremer D, Demissei BG, Struck J, Bergmann A, Anker SD, Voors AA (2019) Bio-adrenomedullin as a marker of congestion in patients with new‐onset and worsening heart failure. Eur J Heart Fail 21(6):732–743

Article  CAS  PubMed  Google Scholar 

Caironi P, Latini R, Struck J, Hartmann O, Bergmann A, Maggio G, Spanuth E (2017) Circulating biologically active adrenomedullin (bio-ADM) predicts hemodynamic support requirement and mortality during sepsis. Chest 152(2):312–320

Article  PubMed  Google Scholar 

Tolppanen H, Rivas-Lasarte M, Lassus J, Sans-Rosello J, Hartmann O, Lindholm M, Mebazaa A (2017) Adrenomedullin: a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shock. Ann Intensive Care 7(1):1–10

Article  CAS  Google Scholar 

Ishimitsu T, Nishikimi T, Saito Y, Kitamura K, Eto T, Kangawa K, Matsuoka H (1994) Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure. J Clin Invest 94(5):2158–2161

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kremer D, Ter Maaten JM, Voors AA (2018) Bio-adrenomedullin as a potential quick, reliable, and objective marker of congestion in heart failure. Eur J Heart Fail 20(9):1363–1365

Article  PubMed  Google Scholar 

Tang WW (2010) Contemporary challenges in translating biomarker evidence into clinical practice. J Am Coll Cardiol 55:2077–2079

Article  CAS  PubMed  Google Scholar 

Beltowski J, Jamroz A (2004) Adrenomedullin–what do we know 10 years since its discovery? Pol J Pharmacol 56:5–27

CAS  PubMed  Google Scholar 

Owji AA, Smith DM, Coppock HA, Morgan DG, Bhogal RANJEV, Ghatei MA, Bloom SR (1995) An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat. Endocrinology 136(5):2127–2134

Article  CAS  PubMed  Google Scholar 

Wilke N, Janssen H, Fahrenhorst C, Hecker H, Manns MP, Brabant EG, Breitmeier D (2007) Postmortem determination of concentrations of stress hormones in various body fluids—is there a dependency between adrenaline/noradrenaline quotient, cause of death and agony time? Int J Legal Med 121(5):385–394

Article  CAS  PubMed  Google Scholar 

Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Quan L, Maeda H (2007) Postmortem serum catecholamine levels in relation to the cause of death. Forensic Sci Int 173(2–3):122–129

Article  CAS  PubMed  Google Scholar 

Lovallo WR, Farag NH, Vincent AS, Thomas TL, Wilson MF (2006) Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacol Biochem Behav 83(3):441–447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Whitworth JA, Williamson PM, Mangos G, Kelly JJ (2005) Cardiovascular consequences of cortisol excess. Vasc Health Risk Manag 1(4):291

CAS  Google Scholar 

Dugan AL, Malarkey WB, Schwemberger S, Jauch EC, Ogle CK, Horseman ND (2004) Serum levels of prolactin, growth hormone, and cortisol in burn patients: correlations with severity of burn, serum cytokine levels, and fatality. J Burn Care Rehabil 25(3):306–313

Article  CAS  PubMed  Google Scholar 

Desborough JP (2000) The stress response to trauma and surgery. Br J Anaesth 85(1):109–117