Ahmadi A, Mazloomnejad R, Kasravi M et al (2022) Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways. Stem Cell Res Ther 13(1):518. https://doi.org/10.1186/s13287-022-03204-4
Article CAS PubMed PubMed Central Google Scholar
Bensreti H, Alhamad DW, Gonzalez AM et al (2023) Update on the role of glucocorticoid signaling in osteoblasts and bone marrow adipocytes during aging. Curr Osteoporos Rep 21(1):32–44. https://doi.org/10.1007/s11914-022-00772-5
Cao H, Guan H, Lai Y, Qin L, Wang X (2016) Review of various treatment options and potential therapies for osteonecrosis of the femoral head. J Orthop Translat 4:57–70. https://doi.org/10.1016/j.jot.2015.09.005
Chamani S, Liberale L, Mobasheri L et al (2021) The role of statins in the differentiation and function of bone cells. Eur J Clin Invest 51(7):e13534. https://doi.org/10.1111/eci.13534
Article CAS PubMed Google Scholar
Chen J, Zhang C, Yan T et al (2021) Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation. J Cell Physiol 236(10):6920–6931. https://doi.org/10.1002/jcp.30351
Article CAS PubMed Google Scholar
Duan DY, Tang J, Tian HT, Shi YY, Jia J (2021) Adipocyte-secreted microvesicle-derived miR-148a regulates adipogenic and osteogenic differentiation by targeting Wnt5a/Ror2 pathway. Life Sci 278:119548. https://doi.org/10.1016/j.lfs.2021.119548
Article CAS PubMed Google Scholar
Fuster JJ, Zuriaga MA, Ngo DT et al (2015) Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes 64(4):1235–1248. https://doi.org/10.2337/db14-1164
Article CAS PubMed Google Scholar
Gao J, Li L, Zhou D et al (2023) Effects of norepinephrine-induced activation of rat vascular adventitial fibroblasts on proliferation and migration of BMSCs involved in vascular remodeling. Exp Ther Med 25(6):290. https://doi.org/10.3892/etm.2023.11989
Article CAS PubMed PubMed Central Google Scholar
Han L, Wang B, Wang R, Gong S, Chen G, Xu W (2019) The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor. Stem Cell Res Ther 10(1):377. https://doi.org/10.1186/s13287-019-1498-0
Article CAS PubMed PubMed Central Google Scholar
Handal JA, John TK, Goldstein DT et al (2012) Effect of atorvastatin on the cortical bones of corticosteroid treated rabbits. J Orthop Res 30(6):872–876. https://doi.org/10.1002/jor.22030
Article CAS PubMed Google Scholar
Jia B, Jiang Y, Yao Y, Xu Y, Wang Y, Li T (2023) Baicalin attenuates dexamethasone-induced apoptosis of bone marrow mesenchymal stem cells by activating the hedgehog signaling pathway. Chin Med J (engl) 136(15):1839–1847. https://doi.org/10.1097/cm9.0000000000002113
Article CAS PubMed Google Scholar
Jiang Y, Zhang Y, Zhang H et al (2014) Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathway. Exp Biol Med (maywood) 239(3):347–355. https://doi.org/10.1177/1535370213519215
Article CAS PubMed Google Scholar
Kawai M, de Paula FJ, Rosen CJ (2012) New insights into osteoporosis: the bone-fat connection. J Intern Med 272(4):317–329. https://doi.org/10.1111/j.1365-2796.2012.02564.x
Article CAS PubMed PubMed Central Google Scholar
Kerachian MA, Séguin C, Harvey EJ (2009) Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J Steroid Biochem Mol Biol 114(3–5):121–128. https://doi.org/10.1016/j.jsbmb.2009.02.007
Article CAS PubMed PubMed Central Google Scholar
Konarski W, Poboży T, Konarska K et al (2023) Osteonecrosis related to steroid and alcohol use-an update on pathogenesis. Healthcare (basel). https://doi.org/10.3390/healthcare11131846
Lai KA, Shen WJ, Yang CY, Shao CJ, Hsu JT, Lin RM (2005) The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Jt Surg Am 87(10):2155–2159. https://doi.org/10.2106/jbjs.D.02959
Lee GJ, Kim YJ, Park B et al (2022) YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity. Cell Death Dis 13(4):407. https://doi.org/10.1038/s41419-022-04847-0
Article CAS PubMed PubMed Central Google Scholar
Lei B, Wu X, Xia K, Sun H, Wang J (2021) Exosomal micro-RNA-96 derived from bone marrow mesenchymal stem cells inhibits doxorubicin-induced myocardial toxicity by inhibiting the rac1/nuclear factor-κB signaling pathway. J Am Heart Assoc 10(17):e020589. https://doi.org/10.1161/jaha.120.020589
Article CAS PubMed PubMed Central Google Scholar
Li X, Cui Q, Kao C, Wang GJ, Balian G (2003) Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARgamma2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures. Bone 33(4):652–659. https://doi.org/10.1016/s8756-3282(03)00239-4
Article CAS PubMed Google Scholar
Li J, Zhang N, Huang X et al (2013) Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation. Cell Death Dis 4(10):e832. https://doi.org/10.1038/cddis.2013.348
Article CAS PubMed PubMed Central Google Scholar
Li JY, Wang SN, Dong YM (2020) Anti-inflammatory and repaired effects of non-steroidal anti-inflammatory drugs on human dental pulp cells. Beijing Da Xue Xue Bao Yi Xue Ban 52(1):24–29. https://doi.org/10.19723/j.issn.1671-167X.2020.01.004
Article CAS PubMed Google Scholar
Li T, Chan RWS, Lee CL et al (2022) WNT5A interacts with FZD5 and LRP5 to regulate proliferation and self-renewal of endometrial mesenchymal stem-like cells. Front Cell Dev Biol 10:837827. https://doi.org/10.3389/fcell.2022.837827
Article PubMed PubMed Central Google Scholar
Lidell ME, Enerbäck S (2015) Brown adipose tissue and bone. Int J Obes Suppl 5(Suppl 1):S23–S27. https://doi.org/10.1038/ijosup.2015.7
Article CAS PubMed PubMed Central Google Scholar
Liu G, Luo G, Bo Z, Liang X, Huang J, Li D (2016) Impaired osteogenic differentiation associated with connexin43/microRNA-206 in steroid-induced avascular necrosis of the femoral head. Exp Mol Pathol 101(1):89–99. https://doi.org/10.1016/j.yexmp.2016.07.009
Article CAS PubMed Google Scholar
Lu Y, Liu M, Guo X et al (2023) miR-26a-5p alleviates CFA-induced chronic inflammatory hyperalgesia through Wnt5a/CaMKII/NFAT signaling in mice. CNS Neurosci Ther 29(5):1254–1271. https://doi.org/10.1111/cns.14099
Article CAS PubMed PubMed Central Google Scholar
Lv YF, Yu J, Sheng YL et al (2018) Glucocorticoids suppress the browning of adipose tissue via miR-19b in male mice. Endocrinology 159(1):310–322. https://doi.org/10.1210/en.2017-00566
Article CAS PubMed Google Scholar
Maeda K, Kobayashi Y, Udagawa N et al (2012a) Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med 18(3):405–412. https://doi.org/10.1038/nm.2653
Comments (0)