Environmental Protection Agency (EPA). Our current understanding of the human health and environmental risks of PFAS. https://www.epa.gov/pfas/our-current-understanding-human-health-and-environmental-risks-pfas. Accessed 14 March 2024.

Centers for Disease Control and Prevention (CDC). Per- and polyfluorinated substances (PFAS) factsheet. https://www.cdc.gov/biomonitoring/PFAS_FactSheet.html. Accessed 14 March 2024.

Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DC. Biological monitoring of polyfluoroalkyl substances: a review. Environ Sci Technol. 2006;40(11):3463–73.

Article  CAS  PubMed  Google Scholar 

Wallington TJ, Hurley MD, Xia J, Wuebbles DJ, Sillman S, Ito A, Penner JE, Ellis DA, Martin J, Mabury SA, Nielsen OJ, Sulbaek Andersen MP. Formation of C7F15COOH (PFOA) and other perfluorocarboxylic acids during the atmospheric oxidation of 8:2 fluorotelomer alcohol. Environ Sci Technol. 2006;40(3):924–30.

Article  CAS  PubMed  Google Scholar 

Wania F. A global mass balance analysis of the source of perfluorocarboxylic acids in the Arctic Ocean. Environ Sci Technol. 2007;41(13):4529–35.

Article  CAS  PubMed  Google Scholar 

Armitage J, Cousins IT, Buck RC, Prevedouros K, Russell MH, MacLeod M, Korzeniowski SH. Modeling global-scale fate and transport of perfluorooctanoate emitted from direct sources. Environ Sci Technol. 2006;40(22):6969–75.

Article  CAS  PubMed  Google Scholar 

Armitage JM, MacLeod M, Cousins IT. Modeling the global fate and transport of perfluorooctanoic acid (PFOA) and perfluorooctanoate (PFO) emitted from direct sources using a multispecies mass balance model. Environ Sci Technol. 2009;43(4):1134–40.

Article  CAS  PubMed  Google Scholar 

Armitage JM, Macleod M, Cousins IT. Comparative assessment of the global fate and transport pathways of long-chain perfluorocarboxylic acids (PFCAs) and perfluorocarboxylates (PFCs) emitted from direct sources. Environ Sci Technol. 2009;43(15):5830–6.

Article  CAS  PubMed  Google Scholar 

Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, Voogt PD, Jensen AA, Kannan K, Mabury SA, Leeuwen SP. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag. 2011;7(4):513–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oliaei F, Kriens D, Weber R, Watson A. PFOS and PFC releases and associated pollution from a PFC production plant in Minnesota (USA). Environ Sci Pollut Res Int. 2013;20(4):1977–92.

Article  CAS  PubMed  Google Scholar 

National Academies of Sciences, Engineering, and Medicine (NASEM). Guidance on PFAS Exposure, Testing, and Clinical Follow-Up. Washington, DC: The National Academies Press (US); 2022. https://nap.nationalacademies.org/catalog/26156/guidance-on-pfas-exposure-testing-and-clinical-follow-up. Accessed 14 Mar 2024.

Benskin JP, Yeung LW, Yamashita N, Taniyasu S, Lam PK, Martin JW. Perfluorinated acid isomer profiling in water and quantitative assessment of manufacturing source. Environ Sci Technol. 2010;44(23):9049–54.

Article  CAS  PubMed  Google Scholar 

Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Survey Data. 2017–2020 Laboratory data - continuous NHANES. Accessed 31 May 2024.

Sonnenberg NK, Ojewole AE, Ojewole CO, Lucky OP, Kusi J. Trends in serum per- and polyfluoroalkyl substance (PFAS) concentrations in teenagers and adults, 1999–2018 NHANES. Int J Environ Res Public Health. 2023;20(21):6984.

Article  PubMed  PubMed Central  Google Scholar 

Lewis RC, Johns LE, Meeker JD. Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011–2012. Int J Environ Res Public Health. 2015;12(6):6098–114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agency for Toxic Substances and Disease Registry (ATSDR) What are the health effects of PFAS? Reviewed January 18, 2024. https://www.atsdr.cdc.gov/pfas/health-effects/index.html. Accessed 14 March 2024.

International Agency for Research on Cancer (IARC) Working Group. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 110. Some Chemicals Used as Solvents and in Polymer Manufacture. Accessed 14 March 2024.

Environmental Protection Agency (EPA). Health effects support document for perfluorooctanoic acid (PFOA). EPA Document Number: 822-R-16–003 May 2016. https://www.epa.gov/sites/default/files/2016-05/documents/pfoa_hesd_final-plain.pdf. Accessed 14 Mar 2024.

Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J. Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci. 2007;99(2):366–94.

Article  CAS  PubMed  Google Scholar 

Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL, Goldman LR. Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect. 2007;115(11):1670–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fei C, McLaughlin JK, Lipworth L, Olsen J. Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy. Environ Health Perspect. 2008;116(10):1391–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

National Toxicology Program (NTP) U.S. Department of Health and Human Services. Immunotoxicity associated with exposure to perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS). 2016. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/pfoa_pfos/literaturesearch_201605_508.pdf. Accessed 14 Mar 2024.

Lind PM, Salihovic S, van Bavel B, Lind L. Circulating levels of perfluoroalkyl substances (PFASs) and carotid artery atherosclerosis. Environ Res. 2017;152:157–64.

Article  CAS  PubMed  Google Scholar 

Attanasio R. Association between perfluoroalkyl acids and liver function: data on sex differences in adolescents. Data Brief. 2019;5(27): 104618.

Article  Google Scholar 

Zeng X, Chen Q, Zhang X, Li H, Liu Q, Li C, Ma M, Zhang J, Zhang W, Zhang J, Huang L. Association between prenatal exposure to perfluoroalkyl substances and asthma-related diseases in preschool children. Environ Sci Pollut Res Int. 2019;26(29):29639–48.

Article  CAS  PubMed  Google Scholar 

Jain RB. Concentration of selected liver enzymes across the stages of glomerular function: the associations with PFOA and PFOS. Heliyon. 2019;5(7): e02168.

Article  PubMed  PubMed Central  Google Scholar 

Lin PD, Cardenas A, Hauser R, Gold DR, Kleinman KP, Hivert MF, Fleisch AF, Calafat AM, Webster TF, Horton ES, Oken E. Per- and polyfluoroalkyl substances and blood lipid levels in pre-diabetic adults-longitudinal analysis of the diabetes prevention program outcomes study. Environ Int. 2019;129:343–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao F, An Z, Lv J, Sun X, Sun H, Liu Y, Liu X, Guo H. Association between per- and polyfluoroalkyl substances and risk of hypertension: a systematic review and meta-analysis. Front Public Health. 2023;2(11):1173101.

Article  Google Scholar 

Liao S, Yao W, Cheang I, Tang X, Yin T, Lu X, Zhou Y, Zhang H, Li X. Association between perfluoroalkyl acids and the prevalence of hypertension among US adults. Ecotoxicol Environ Saf. 2020;15(196): 110589.

Article  Google Scholar 

Chen Z, Yang T, Walker DI, Thomas DC, Qiu C, Chatzi L, Alderete TL, Kim JS, Conti DV, Breton CV, Liang D, Hauser ER, Jones DP, Gilliland FD. Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults. Environ Int. 2020;145: 106091.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin PD, Cardenas A, Hauser R, Gold DR, Kleinman KP, Hivert MF, Calafat AM, Webster TF, Horton ES, Oken E. Per- and polyfluoroalkyl substances and blood pressure in pre-diabetic adults-cross-sectional and longitudinal analyses of the diabetes prevention program outcomes study. Environ Int. 2020;137: 105573.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Zhao L, Ducatman A, Deng C, von Stackelberg KE, Danford CJ, Zhang X. Association of per- and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults. JHEP Rep. 2023;5(5): 100694.

Article  PubMed  PubMed Central  Google Scholar 

Jin R, McConnell R, Catherine C, Xu S, Walker DI, Stratakis N, Jones DP, Miller GW, Peng C, Conti DV, Vos MB, Chatzi L. Perfluoroalkyl substances and severity of nonalcoholic fatty liver in children: an untargeted metabolomics approach. Environ Int. 2020;134: 105220.

Article  CAS  PubMed  Google Scholar 

Ding N, Harlow SD, Randolph JF Jr, Loch-Caruso R, Park SK. Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary. Hum Reprod Update. 2020;26(5):724–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dzierlenga MW, Allen BC, Clewell HJ