Claire N. Harrison reports consultancy with Novartis, MorphoSys, Sierra, Constellation, AOP, Galecto, Keros, AbbVie, Geron, Janssen, Promedior, Sumitomo, GSK, and CTI; participation in a company-sponsored speakers’ bureau for AbbVie, BMS, Celgene, CTI, and Novartis; research funding from Constellation, Novartis, Celgene (BMS), and Imago Biosciences, Inc., a subsidiary of Merck & Co.; sole ownership and directorship of Chakana Medical Limited; advisory roles with Galecto and Keros; patents and royalties from Blood Cancer UK, BMS, Chakana Medical, Constellation, EHA, MPN Voice, and Novartis; and honoraria from BMS, Novartis, CTI, GSK, AOP, Galecto, AbbVie, and MorphoSys. Alessandro M. Vannucchi reports honoraria from Incyte, Novartis, BMS, GSK, AbbVie, Roche, and AOP. Christian Recher reports honoraria from and an advisory role with AbbVie, Astellas, Amgen, BMS, Jazz Pharmaceuticals, Novartis, and Servier and research funding from AbbVie, Astellas, Amgen, BMS, Jazz Pharmaceuticals, and Servier. Francesco Passamonti reports honoraria from AbbVie, AOP Orphan, and Bristol Myers Squibb/Celgene and consultancy with AbbVie, AOP Orphan, Celgene, Bristol Myers Squibb, Janssen, Kartos, Karyopharm, Kyowa Kirin, MEI, Novartis, Roche, Sierra Oncology, and Sumitomo. Aaron T. Gerds reports consultancy with AbbVie, Bristol Myers Squibb, Celgene, Constellation Pharmaceuticals, GSK, Kartos, Novartis, PharmaEssentia, and Sierra Oncology; consultancy with and research funding from CTI BioPharma, Imago BioSciences/Merck, and Constellation Pharmaceuticals/MorphoSys; research funding from Accurate Pharmaceuticals, Constellation Pharmaceuticals, CTI BioPharma, Imago BioSciences, Incyte Corporation, and Kartos Pharmaceuticals; and an advisory role with AbbVie, Bristol Myers Squibb, CTI BioPharma, GSK, Imago, Kartos, MorphoSys, PharmaEssentia, and Rain Oncology. Juan Carlos Hernandez-Boluda reports an advisory role with Incyte, Pfizer, Novartis, and BMS. Abdulraheem Yacoub reports consultancy with Incyte, CTI Pharma, PharmaEssentia, Pfizer, Novartis, and Acceleron Pharma. Shireen Sirhan reports honoraria from Constellation and consultancy with and honoraria from GSK, Novartis, and Constellation. Catherine Ellis, Bharat Patel, and Bryan Strouse are employees of GSK. Uwe Platzbecker reports consultancy with AbbVie, Curis, and Geron and an advisory role with MDS Foundation. All authors acknowledge editorial support in the preparation of this manuscript, funded by GSK.

This study was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice. The study protocol was approved by the institutional review board or independent ethics committee at each study site (Supplementary Material), and all participants provided written informed consent.