Relative increase in production ratio of small dense low-density lipoprotein in acute coronary syndrome with high coronary plaque burden: an ex-vivo analysis

Brunner FJ, Waldeyer C, Ojeda F, Salomaa V, Kee F, Sans S, Thorand B, Giampaoli S, Brambilla P, Tunstall-Pedoe H, Moitry M, Iacoviello L, Veronesi G, Grassi G, Mathiesen EB, Söderberg S, Linneberg A, Brenner H, Amouyel P, Ferrières J, Tamosiunas A, Nikitin YP, Drygas W, Melander O, Jöckel KH, Leistner DM, Shaw JE, Panagiotakos DB, Simons LA, Kavousi M, Vasan RS, Dullaart RPF, Wannamethee SG, Risérus U, Shea S, de Lemos JA, Omland T, Kuulasmaa K, Landmesser U, Blankenberg S, Multinational Cardiovascular Risk Consortium (2019) Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium. Lancet 394:2173–2183

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, Hegele RA, Krauss RM, Raal FJ, Schunkert H, Watts GF, Borén J, Fazio S, Horton JD, Masana L, Nicholls SJ, Nordestgaard BG, van de Sluis B, Taskinen MR, Tokgözoglu L, Landmesser U, Laufs U, Wiklund O, Stock JK, Chapman MJ, Catapano AL (2017) Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 38:2459–2472

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nordestgaard BG (2016) Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease. Circ Res 118:547–563

Article  CAS  PubMed  Google Scholar 

Sniderman AD, Thanassoulis G, Glavinovic T, Navar AM, Pencina M, Catapano A, Ference BA (2019) Apolipoprotein B particles and cardiovascular disease: a narrative review. JAMA Cardiol 4:1287–1295

Article  PubMed  PubMed Central  Google Scholar 

No authors listed (1998) Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 339:1349–1357

Article  Google Scholar 

Pedersen TR, Kjekshus J, Berg K, Haghfelt T, Faergeman O, Faergeman G, Pyörälä K, Miettinen T, Wilhelmsen L, Olsson AG, Wedel H, Scandinavian Simvastatin Survival Study Group (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344:1383–1389

Google Scholar 

Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, Brown L, Warnica JW, Arnold JM, Wun CC, Davis BR, Braunwald E (1996) The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 335:1001–1009

Article  CAS  PubMed  Google Scholar 

Miura-Takahashi E, Tashiro K, Shiga Y, Kawahira Y, Kato Y, Kuwano T, Sugihara M, Otsu Y, Kamimura H, Miura S (2024) Association between pre-treatment with statin and its inhibitory effect on the onset of coronary artery disease at the time of coronary computed tomography angiography: a new look at an old medication. Heart Vessels. https://doi.org/10.1007/s00380-024-02407-4

Article  PubMed  Google Scholar 

Hirayama S, Miida T (2012) Small dense LDL: an emerging risk factor for cardiovascular disease. Clin Chim Acta 414:215–224

Article  CAS  PubMed  Google Scholar 

Sekimoto T, Koba S, Mori H, Sakai R, Arai T, Yokota Y, Sato S, Tanaka H, Masaki R, Oishi Y, Ogura K, Arai K, Nomura K, Kosaki R, Sakai K, Tsujita H, Kondo S, Tsukamoto S, Tsunoda F, Shoji M, Matsumoto H, Hamazaki Y, Shinke T (2021) small dense low-density lipoprotein cholesterol: a residual risk for rapid progression of non-culprit coronary lesion in patients with acute coronary syndrome. J Atheroscler Thromb 28:1161–1174

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koizumi T, Kaneda H, Komiyama N, Inoue I, Muramatsu T, Nakajima K (2021) Lipoprotein profiles before heparin administration in patients with or without coronary thrombosis following atherosclerosis. Ann Vasc Dis 14:31–38

Article  PubMed  PubMed Central  Google Scholar 

Inoue I, Kubota R, Yanagi S, Akita M, Nakano T, Katayama S, Shimada A, Noda M (2017) The new molecular entity evolocumab, one kind of PCSK9 inhibitor, reduce plasma small size LDL-cholesterol levels by using a new standardized method of measuring LDL size. Op J Molec Integr Physiol 7:1–23

Article  Google Scholar 

Nicholls SJ, Puri R, Anderson T, Ballantyne CM, Cho L, Kastelein JJ, Koenig W, Somaratne R, Kassahun H, Yang J, Wasserman SM, Scott R, Ungi I, Podolec J, Ophuis AO, Cornel JH, Borgman M, Brennan DM, Nissen SE (2016) Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial. JAMA 316:2373–2384

Article  CAS  PubMed  Google Scholar 

Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, Mehran R, McPherson J, Farhat N, Marso SP, Parise H, Templin B, White R, Zhang Z, Serruys PW, PROSPECT Investigators (2011) A prospective natural-history study of coronary atherosclerosis. N Engl J Med 364:226–235

Article  CAS  PubMed  Google Scholar 

Nikolic D, Katsiki N, Montalto G, Isenovic ER, Mikhailidis DP, Rizzo M (2013) Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches. Nutrients 5:928–948

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ivanova EA, Myasoedova VA, Melnichenko AA, Grechko AV, Orekhov AN (2017) Small dense low-density lipoprotein as biomarker for atherosclerotic diseases. Oxid Med Cell Longev 2017:1273042

Article  PubMed  PubMed Central  Google Scholar 

Zheng C, Khoo C, Furtado J, Sacks FM (2010) Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype. Circulation 121:1722–1734

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ (2004) Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med 350:1505–1515

Article  CAS  PubMed  Google Scholar 

Krauss RM, Wojnooski K, Orr J, Geaney JC, Pinto CA, Liu Y, Wagner JA, Luk JM, Johnson-Levonas AO, Anderson MS, Dansky HM (2012) Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib. J Lipid Res 53:540–547

Article  CAS  PubMed  PubMed Central  Google Scholar 

Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ (2010) From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466:714–719

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffin BA, Freeman DJ, Tait GW, Thomson J, Caslake MJ, Packard CJ, Shepherd J (1994) Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis 106:241–253

Article  CAS  PubMed  Google Scholar 

Carmena R, Duriez P, Fruchart JC (2004) Atherogenic lipoprotein particles in atherosclerosis. Circulation 109:Iii2-7

Article  PubMed  Google Scholar 

Packard C, Caslake M, Shepherd J (2000) The role of small, dense low density lipoprotein (LDL): a new look. Int J Cardiol 74(Suppl 1):S17–S22

Article  PubMed  Google Scholar 

Griffin BA (1999) Lipoprotein atherogenicity: an overview of current mechanisms. Proc Nutr Soc 58:163–169

Article  CAS  PubMed  Google Scholar 

Tertov VV, Kaplun VV, Sobenin IA, Boytsova EY, Bovin NV, Orekhov AN (2001) Human plasma trans-sialidase causes atherogenic modification of low density lipoprotein. Atherosclerosis 159:103–115

Article  CAS  PubMed  Google Scholar 

Steinberg D, Witztum JL (2010) Oxidized low-density lipoprotein and atherosclerosis. Arterioscler Thromb Vasc Biol 30:2311–2316

Article  CAS  PubMed  Google Scholar 

Jaakkola O, Solakivi T, Tertov VV, Orekhov AN, Miettinen TA, Nikkari T (1993) Characteristics of low-density lipoprotein subfractions from patients with coronary artery disease. Coron Artery Dis 4:379–385

Article  CAS  PubMed  Google Scholar 

Khazaei M, Moien-Afshari F, Laher I (2008) Vascular endothelial function in health and diseases. Pathophysiology 15:49–67

Article  CAS 

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