Salik B, Yi H, Hassan N, Santiappillai N, Vick B, Connerty P, et al. Targeting RSPO3-LGR4 signaling for leukemia stem cell eradication in acute myeloid leukemia. Cancer Cell. 2020;38(2):263–78.e6.

Article  CAS  PubMed  Google Scholar 

Liu J, Xiao Q, Xiao J, Niu C, Li Y, Zhang X, Zhou Z, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 2022 Jan 3;7(1):3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi BR, Cave C, Na CH, Sockanathan S. GDE2-dependent activation of canonical wnt signaling in neurons regulates oligodendrocyte maturation. Cell Rep. 2020;31(5):107540.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010;327(5973):1650–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hawkins AG, Pedersen EA, Treichel S, Temprine K, Sperring C, Read JA et al. Wnt/β-catenin-activated ewing sarcoma cells promote the angiogenic switch. JCI Insight. 2020;5(13).

Unno K, Chalmers ZR, Pamarthy S, Vatapalli R, Rodriguez Y, Lysy B, et al. Activated ALK cooperates with N-Myc via Wnt/β-Catenin signaling to induce neuroendocrine prostate cancer. Cancer Res. 2021;81(8):2157–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahmoudvand S, Shokri S, Taherkhani R, Farshadpour F. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. World J Gastroenterol. 2019;25(1):42–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Cai H, Liu Q, Xia Y, Xing L, Zuo Q, et al. Cinobufacini inhibits colon cancer invasion and metastasis via suppressing Wnt/β-Catenin signaling pathway and EMT. Am J Chin Med. 2020;48(3):703–18.

Article  CAS  PubMed  Google Scholar 

Ghasemi F, Shafiee M, Banikazemi Z, Pourhanifeh MH, Khanbabaei H, Shamshirian A, et al. Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells. Pathol Res Pract. 2019;215(10):152556.

Article  CAS  PubMed  Google Scholar 

Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014;159(1):80–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dihlmann S, Siermann A, von Knebel Doeberitz M. The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001;20(5):645–53.

Article  CAS  PubMed  Google Scholar 

Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, et al. Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway. EBioMedicine. 2019;39:239–54.

Article  PubMed  Google Scholar 

Cheng X, Xu X, Chen D, Zhao F, Wang W. Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer. Biomed Pharmacother. 2019;110:473–81.

Article  CAS  PubMed  Google Scholar 

Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 1982;31(1):99–109.

Article  CAS  PubMed  Google Scholar 

Kühl M, Sheldahl LC, Malbon CC, Moon RT. Ca(2+)/calmodulin-dependent protein kinase II is stimulated by wnt and frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem. 2000;275(17):12701–11.

Article  PubMed  Google Scholar 

Freisinger CM, Fisher RA, Slusarski DC. Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning. PLoS Genet. 2010;6(7):e1001020.

Article  PubMed  PubMed Central  Google Scholar 

Habas R, Dawid IB. Dishevelled and wnt signaling: is the nucleus the final frontier? J Biol. 2005;4(1):2.

Article  PubMed  PubMed Central  Google Scholar 

He X. A wnt-wnt situation. Dev Cell. 2003;4(6):791–7.

Article  CAS  PubMed  Google Scholar 

Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, et al. A dual-kinase mechanism for wnt co-receptor phosphorylation and activation. Nature. 2005;438(7069):873–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willert K, Nusse R. Wnt proteins. Cold Spring Harb Perspect Biol. 2012;4(9):a007864.

Article  PubMed  PubMed Central  Google Scholar 

Ke J, Xu HE, Williams BO. Lipid modification in wnt structure and function. Curr Opin Lipidol. 2013;24(2):129–33.

Article  CAS  PubMed  Google Scholar 

He X, Semenov M, Tamai K, Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development. 2004;131(8):1663–77.

Article  CAS  PubMed  Google Scholar 

Alok A, Lei Z, Jagannathan NS, Kaur S, Harmston N, Rozen SG, et al. Wnt proteins synergize to activate β-catenin signaling. J Cell Sci. 2017;130(9):1532–44.

Article  CAS  PubMed  Google Scholar 

Komiya Y, Habas R. Wnt signal transduction pathways. Organogenesis. 2008;4(2):68–75.

Article  PubMed  PubMed Central  Google Scholar 

Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 2013;13(1):11–26.

Article  CAS  PubMed  Google Scholar 

Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S. Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation. Mol Cell. 2021;81(16):3246–e6111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nusse R, Clevers H. Wnt/β-Catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169(6):985–99.

Article  CAS  PubMed  Google Scholar 

Wiese KE, Nusse R, van Amerongen R. Wnt signalling: conquering complexity. Development. 2018;145(12).

Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science. 2007;316(5831):1619–22.

Article  CAS  PubMed  Google Scholar 

Kusserow A, Pang K, Sturm C, Hrouda M, Lentfer J, Schmidt HA, et al. Unexpected complexity of the wnt gene family in a sea anemone. Nature. 2005;433(7022):156–60.

Article  CAS  PubMed  Google Scholar 

Yu J, Chia J, Canning CA, Jones CM, Bard FA, Virshup DM. WLS retrograde transport to the endoplasmic reticulum during wnt secretion. Dev Cell. 2014;29(3):277–91.

Article  CAS  PubMed  Google Scholar 

Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, et al. International union of pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev. 2005;57(2):279–88.