Serum Neurofilament Light-Chain Concentrations in Essential Tremor: a Case–Control Study

Benito-Leon J, Labiano-Fontcuberta A. Linking essential tremor to the cerebellum: clinical evidence. Cerebellum. 2016;15(3):253–62.

Article  PubMed  Google Scholar 

Cerasa A, Quattrone A. Linking essential tremor to the cerebellum-neuroimaging evidence. Cerebellum. 2016;15(3):263–75.

Article  CAS  PubMed  Google Scholar 

Louis ED, Frucht SJ, Rios E. Intention tremor in essential tremor: Prevalence and association with disease duration. Mov Disord. 2009;24(4):626–7.

Article  PubMed  PubMed Central  Google Scholar 

Rao AK, Louis ED. Ataxic gait in essential tremor: a disease-associated feature? Tremor Other Hyperkinet Mov (N Y). 2019;9. https://doi.org/10.7916/d8-28jq-8t52.

Louis ED. De Sedibus et Causis morborum: is essential tremor a primary disease of the cerebellum? Cerebellum. 2016;15(3):233–4.

Article  PubMed  Google Scholar 

Louis ED, Martuscello RT, Gionco JT, Hartstone WG, Musacchio JB, Portenti M, et al. Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains. Acta Neuropathol. 2023;145(3):265–83.

Article  PubMed  PubMed Central  Google Scholar 

Louis ED, Faust PL. Essential tremor: the most common form of cerebellar degeneration? Cerebellum Ataxias. 2020;7:12.

Article  PubMed  PubMed Central  Google Scholar 

Fyfe I. Neurofilament light chain - new potential for prediction and prognosis. Nat Rev Neurol. 2019;15(10):557.

Article  PubMed  Google Scholar 

Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, et al. Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol. 2018;14(10):577–89.

Article  CAS  PubMed  Google Scholar 

Louis ED, Faust PL. Essential tremor pathology: neurodegeneration and reorganization of neuronal connections. Nat Rev Neurol. 2020;16(2):69–83.

Article  CAS  PubMed  Google Scholar 

Louis ED, Ma K, Babij R, Cortes E, Liem RK, Vonsattel JP, et al. Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex. Neurosci Lett. 2012;518(1):49–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Louis ED, McCreary M. How common is essential tremor? Update on the worldwide prevalence of essential tremor. Tremor Other Hyperkinet Mov (N Y). 2021;11:28.

Article  PubMed  Google Scholar 

Louis ED, Ottman R, Ford B, Pullman S, Martinez M, Fahn S, et al. The Washington Heights-Inwood Genetic Study of Essential Tremor: methodologic issues in essential-tremor research. Neuroepidemiology. 1997;16(3):124–33.

Article  CAS  PubMed  Google Scholar 

Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9.

Article  PubMed  Google Scholar 

Marques TM, van Rumund A, Oeckl P, Kuiperij HB, Esselink RAJ, Bloem BR, et al. Serum NFL discriminates Parkinson disease from atypical parkinsonisms. Neurology. 2019;92(13):e1479–86.

Article  PubMed  Google Scholar 

Kuhle J, Kropshofer H, Haering DA, Kundu U, Meinert R, Barro C, et al. Blood neurofilament light chain as a biomarker of MS disease activity and treatment response. Neurology. 2019;92(10):e1007–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akamine S, Marutani N, Kanayama D, Gotoh S, Maruyama R, Yanagida K, et al. Renal function is associated with blood neurofilament light chain level in older adults. Sci Rep. 2020;10(1):20350.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Huang C, Zhang Q, Shen T, Sun J. Serum NFL discriminates Parkinson disease from essential tremor and reflect motor and cognition severity. BMC Neurol. 2022;22(1):39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stacy MA, Elble RJ, Ondo WG, Wu SC, Hulihan J, group TRSs. Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tremor Rating Scale in essential tremor. Mov Disord. 2007;22(6):833–8.

Article  PubMed  Google Scholar 

Lin CH, Li CH, Yang KC, Lin FJ, Wu CC, Chieh JJ, et al. Blood NfL: a biomarker for disease severity and progression in Parkinson disease. Neurology. 2019;93(11):e1104–11.

Article  CAS  PubMed  Google Scholar 

Oosterveld LP, Verberk IMW, Majbour NK, El-Agnaf OM, Weinstein HC, Berendse HW, et al. CSF or serum neurofilament light added to alpha-Synuclein panel discriminates Parkinson’s from controls. Mov Disord. 2020;35(2):288–95.

Article  CAS  PubMed  Google Scholar 

Potter-Nerger M, Dutke J, Lezius S, Buhmann C, Schulz R, Gerloff C, et al. Serum neurofilament light chain and postural instability/gait difficulty (PIGD) subtypes of Parkinson’s disease in the MARK-PD study. J Neural Transm (Vienna). 2022;129(3):295–300.

Article  PubMed  Google Scholar 

Williams T, Zetterberg H, Chataway J. Neurofilaments in progressive multiple sclerosis: a systematic review. J Neurol. 2021;268(9):3212–22.

Article  PubMed  Google Scholar 

Hayer SN, Liepelt I, Barro C, Wilke C, Kuhle J, Martus P, et al. NfL and pNfH are increased in Friedreich’s ataxia. J Neurol. 2020;267(5):1420–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chelban V, Nikram E, Perez-Soriano A, Wilke C, Foubert-Samier A, Vijiaratnam N, et al. Neurofilament light levels predict clinical progression and death in multiple system atrophy. Brain. 2022;145(12):4398–408.

Article  PubMed  PubMed Central  Google Scholar 

Mattsson N, Cullen NC, Andreasson U, Zetterberg H, Blennow K. Association between longitudinal plasma neurofilament light and neurodegeneration in patients with Alzheimer disease. JAMA Neurol. 2019;76(7):791–9.

Article  PubMed  PubMed Central  Google Scholar 

Halloway S, Desai P, Beck T, Aggarwal N, Agarwal P, Evans D, et al. Association of neurofilament light with the development and severity of Parkinson disease. Neurology. 2022;98(22):e2185–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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