American Cancer Society. Cancer Facts & Figures 2022. Atlanta: American Cancer Society; 2022.
DiSipio T, Rye S, Newman B, Hayes S. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol. 2013;14(6):500–15.
Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, et al. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA. 2013;310(14):1455–61.
Article CAS PubMed PubMed Central Google Scholar
Giuliano AE, Ballman KV, McCall L, Beitsch PD, Brennan MB, Kelemen PR, et al. Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial. JAMA. 2017;318(10):918–26.
Article PubMed PubMed Central Google Scholar
Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, et al. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981–22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014;15(12):1303–10.
Article PubMed PubMed Central Google Scholar
Society of Surgical Oncology. Choosing wisely. 2016. Available at: https://www.surgonc.org/wp-content/uploads/2020/11/SSO-5things-List_2020-Updates-11-2020.pdf. Accessed 10 Nov 2023
The American Society of Breast Surgeons. Consensus guideline on axillary management for patients with in-situ and invasive breast cancer: a concise overview. 2022. Available at: https://www.breastsurgeons.org/resources/statements. Accessed 10 Nov 2023
Rafn BS, Christensen J, Larsen A, Bloomquist K. Prospective surveillance for breast cancer-related arm lymphedema: a systematic review and meta-analysis. J Clin Oncol. 2022;40(9):1009–26.
Kilgore LJ, Korentager SS, Hangge AN, Amin AL, Balanoff CR, Larson KE, et al. Reducing breast cancer-related lymphedema (BCRL) through prospective surveillance monitoring using bioimpedance spectroscopy (BIS) and patient directed self-interventions. Ann Surg Oncol. 2018;25(10):2948–52.
Ridner SH, Dietrich MS, Cowher MS, Taback B, McLaughlin S, Ajkay N, et al. A randomized trial evaluating bioimpedance spectroscopy versus tape measurement for the prevention of lymphedema following treatment for breast cancer: interim analysis. Ann Surg Oncol. 2019;26(10):3250–9.
Article PubMed PubMed Central Google Scholar
Ridner SH, Dietrich MS, Boyages J, Koelmeyer L, Elder E, Hughes TM, et al. A comparison of bioimpedance spectroscopy or tape measure triggered compression intervention in chronic breast cancer lymphedema prevention. Lymphat Res Biol. 2022;20(6):618–28. This randomized control trial examines lymphedema surveillance with either tape measure vs bioimpedance, with initiation of compression therapy if threshold is met. The authors found that in both arms a small portion of patients progressed to require complex decongestive therapy, supporting improved outcomes with surveillance.
Article CAS PubMed PubMed Central Google Scholar
Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L. Advances in the prevention and treatment of breast cancer-related lymphedema. Breast Cancer Res Treat. 2023;200(1):1–14.
Article PubMed PubMed Central Google Scholar
Paramanandam VS, Dylke E, Clark GM, Daptardar AA, Kulkarni AM, Nair NS, et al. Prophylactic use of compression sleeves reduces the incidence of arm swelling in women at high risk of breast cancer-related lymphedema: a randomized controlled trial. J Clin Oncol. 2022;40(18):2004–12. This randomized control trial compares prophylactic post-operative compression sleeves vs standard of care until 3 months after completion of adjuvant therapy. They found decreased arm swelling by bioimpedence with prophylactic compression.
Article CAS PubMed Google Scholar
Thompson M, Korourian S, Henry-Tillman R, Adkins L, Mumford S, Westbrook KC, et al. Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation. Ann Surg Oncol. 2007;14(6):1890–5.
Tummel E, Ochoa D, Korourian S, Betzold R, Adkins L, McCarthy M, et al. Does axillary reverse mapping prevent lymphedema after lymphadenectomy? Ann Surg. 2017;265(5):987–92.
Coriddi M, Dayan J, Bloomfield E, McGrath L, Diwan R, Monge J, et al. Efficacy of immediate lymphatic reconstruction to decrease incidence of breast cancer-related lymphedema: preliminary results of randomized controlled trial. Ann Surg. 2023. This study is a preliminary analysis of a randomized control trial comparing immediate lymphatic reconstruction vs control after ALND. Final analysis with longer-term follow up is planned to be published in the future.
Le NK, Liu L, Jesus Cruz R, Parikh J, Rotatori RM, Wainwright DJ, et al. Efficacy of immediate lymphatic reconstruction in prevention of breast cancer-related lymphedema. Ann Plast Surg. 2023;90(6S Suppl 4):S363–5.
Article CAS PubMed Google Scholar
Hill WKF, Deban M, Platt A, Rojas-Garcia P, Jost E, Temple-Oberle C. Immediate lymphatic reconstruction during axillary node dissection for breast cancer: a systematic review and meta-analysis. Plast Reconstr Surg Glob Open. 2022;10(5):e4291.
Article PubMed PubMed Central Google Scholar
Lin Q, Yang T, Yongmei J, et al. Prediction models for breast cancer-related lymphedema: a systematic review and critical appraisal. Syst Rev. 2022;11:217.
Article PubMed PubMed Central Google Scholar
Rochlin DH, Barrio AV, McLaughlin S, Van Zee KJ, Woods JF, Dayan JH, et al. Feasibility and clinical utility of prediction models for breast cancer-related lymphedema incorporating racial differences in disease incidence. JAMA Surg. 2023;158(9):954–64.
Position Statement of the National Lymphedema Network. Screening and early detection of breast cancer related lymphedema: the imperative. 2011. Available at https://lymphnet.org/position-papers. Accessed 10 Nov 2023
McLaughlin SA, DeSnyder SM, Klimberg S, Alatriste M, Boccardo F, Smith ML, et al. Considerations for clinicians in the diagnosis, prevention, and treatment of breast cancer-related lymphedema, recommendations from an expert panel: part 2: preventive and therapeutic options. Ann Surg Oncol. 2017;24(10):2827–35.
NCCN Clinical Practice Guidelines in Oncology. Survivorship.Version 1.2023. 2023. Available at https://www.nccn.org/professionals/physician_gls/pdf/survivorship.pdf. Accessed 10 Nov 2023
Executive Committee of the International Society of L. The diagnosis and treatment of peripheral lymphedema: 2020 Consensus Document of the International Society of Lymphology. Lymphology. 2020;53(1):3–19.
Ostby PL, Armer JM, Dale PS, Van Loo MJ, Wilbanks CL, Stewart BR. Surveillance recommendations in reducing risk of and optimally managing breast cancer-related lymphedema. J Pers Med. 2014;4(3):424–47.
Article PubMed PubMed Central Google Scholar
Paskett ED, Le-Rademacher J, Oliveri JM, Liu H, Seisler DK, Sloan JA, et al. A randomized study to prevent lymphedema in women treated for breast cancer: CALGB 70305 (Alliance). Cancer. 2021;127(2):291–9. This multi-centered, randomized control trial compared prophylactic compression plus education to education only after breast cancer surgery. They found no difference in rates of lymphedema at 18 months, but had low rate of compliance.
Rupp J, Hadamitzky C, Henkenberens C, Christiansen H, Steinmann D, Bruns F. Frequency and risk factors for arm lymphedema after multimodal breast-conserving treatment of nodal positive breast cancer - a long-term observation. Radiat Oncol. 2019;14(1):39.
Article PubMed PubMed Central Google Scholar
Brunelle C, Skolny M, Ferguson C, Swaroop M, O’Toole J, Taghian AG. Establishing and sustaining a prospective screening program for breast cancer-related lymphedema at the massachusetts general hospital: lessons learned. J Pers Med. 2015;5(2):153–64.
Article PubMed PubMed Central Google Scholar
Norman SA, Localio AR, Potashnik SL, SimoesTorpey HA, Kallan MJ, Weber AL, et al. Lymphedema in breast cancer survivors: incidence, degree, time course, treatment, and symptoms. J Clin Oncol. 2009;27(3):390–7.
Article PubMed PubMed Central Google Scholar
Petrek JA, Senie RT, Peters M, Rosen PP. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer. 2001;92(6):1368–77.
Article CAS PubMed Google Scholar
Armer JM, Stewart BR. Post-breast cancer lymphedema: incidence increases from 12 to 30 to 60 months. Lymphology. 2010;43(3):118–27.
CAS PubMed PubMed Central Google Scholar
McDuff SGR, Mina AI, Brunelle CL, Salama L, Warren LEG, Abouegylah M, et al. Timing of lymphedema after treatment for breast cancer: when are patients most at risk? Int J Radiat Oncol Biol Phys. 2019;103(1):62–70. This large, retrospective review examines risk factors for development of breast cancer related lymphedema with long term follow up and examines risk factors for timing of lymphedema onset.
McLaughlin SA, Bagaria S, Gibson T, Arnold M, Diehl N, Crook J, et al. Trends in risk reduction practices for the prevention of lymphedema in the first 12 months after breast cancer surgery. J Am Coll Surg. 2013;216(3):380–9 (quiz 511-3).
Gandhi A, Xu T, DeSnyder SM, Smith GL, Lin R, Barcenas CH, et al. Prospective, early longitudinal assessment of lymphedema-related quality of life among patients with locally advanced breast cancer: the foundation for building a patient-centered screening program. Breast. 2023;68:205–15.
Article PubMed PubMed Central Google Scholar
Ferguson CM, Swaroop MN, Horick N, Skolny MN, Miller CL, Jammallo LS, et al. Impact of ipsilateral blood draws, injections, blood pressure measurements, and air travel on the risk of lymphedema for patients treated for breast cancer. J Clin Oncol. 2016;34(7):691–8.
Cemal Y, Pusic A, Mehrara BJ. Preventative measures for lymphedema: separating fact from fiction. J Am Coll Surg. 2011;213(4):543–51.
Article PubMed PubMed Central Google Scholar
Jammallo LS, Miller CL, Horick NK, Skolny MN, O’Toole J, Specht MC, et al. Factors associated with fear of lymphedema after treatment for breast cancer. Oncol Nurs Forum. 2014;41(5):473–83.
Uhlmann RA, Mott SL, Curry M, Phadke S, Sugg SL, Erdahl LM, et al. Analysis of the understanding and worry about lymphedema of patients with breast cancer. Ann Surg Oncol. 2022;29(10):6428–37.
Yates HSK. At what point can I lift things? Women’s satisfaction with lymphoedema prevention information after breast cancer surgery. Collegian. 2019;26(3):335–40.
Perdomo M, Davies C, Levenhagen K, Ryans K, Gilchrist L. Patient education for breast cancer-related lymphedema: a systematic review. J Cancer Surviv. 2023;17(2):384–98.
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