Ototoxic and nephrotoxic drugs in neonatal intensive care units: results of a Spanish and Italian survey

Schrier L, Hadjipanayis A, Stiris T, Ross-Russell RI, Valiulis A, Turner MA, Zhao W, De Cock P, de Wildt SN, Allegaert K, van den Anker J (2020) Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology. Eur J Pediatr 179:839–847

Article  PubMed  Google Scholar 

Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Developmental pharmacology–drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167

Article  CAS  PubMed  Google Scholar 

Allegaert K, Verbesselt R, Naulaers G, Van den Anker J, Rayyan M, Debeer A, de Hoon J (2008) Developmental pharmacology: neonates are not just small adults…. Acta Clin Belg 63:16–24

Article  CAS  PubMed  Google Scholar 

Allegaert K, Van De Velde M, van den Anker J (2014) Neonatal clinical pharmacology. Pediatr Anesthesia 24:30–38

Article  Google Scholar 

Allegaert K, van den Anker JN (2014) Clinical pharmacology in neonates: small size, huge variability. Neonatology 105:344–349

Article  CAS  PubMed  Google Scholar 

Allegaert K, van den Anker JN (2022) From immature pharmacotherapy towards pharmacotherapy of the immature. Semin Fetal Neonatal Med. Elsevier 27:101327

Article  Google Scholar 

van den Anker J, Reed MD, Allegaert K, Kearns GL (2018) Developmental Changes in Pharmacokinetics and Pharmacodynamics. J Clin Pharmacol 58(Suppl 10):S10–S25

PubMed  Google Scholar 

Aka I, Bernal CJ, Carroll R, Maxwell-Horn A, Oshikoya KA, Van Driest SL (2017) Clinical pharmacogenetics of cytochrome P450-associated drugs in children. J Personalized Med 7:14

Article  Google Scholar 

Gijsen M, Vlasselaers D, Spriet I, Allegaert K (2021) Pharmacokinetics of Antibiotics in Pediatric Intensive Care: Fostering Variability to Attain Precision Medicine. Antibiotics (Basel) 10:1182

Article  CAS  PubMed  Google Scholar 

McDermott JH, Mahaveer A, James RA, Booth N, Turner M, Harvey KE, Miele G et al (2022) Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care. JAMA Pediatr 176:486–492

Article  PubMed  PubMed Central  Google Scholar 

Lanvers-Kaminsky C, Aa Z-D, Parfitt R, Ciarimboli G (2017) Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies. Clin Pharmacol Ther 101:491–500

Article  CAS  PubMed  Google Scholar 

Rigobello R, Shaw J, Ilg D, Zimmerman R, Edelmann L, Kornreich R, Scott SA, Cody N (2023) Clinical Pharmacogenomic MT-RNR1 Screening for Aminoglycoside-Induced Ototoxicity and the Post-Test Counseling Conundrum. Clin Pharmacol Ther 114:262–265

Article  CAS  PubMed  Google Scholar 

McDermott JH, Wolf J, Hoshitsuki K, Huddart R, Caudle KE, Whirl-Carrillo M, Steyger PS, Smith RJH, Cody N, Rodriguez-Antona C, Klein TE, Newman WG (2022) Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype. Clin Pharmacol Ther 111:366–372

Article  CAS  PubMed  Google Scholar 

Leowattana W (2019) Antiviral drugs and acute kidney injury (AKI). Infect Disord Drug Targets 19:375–382

Article  CAS  PubMed  Google Scholar 

Misurac JM, Knoderer CA, Leiser JD, Nailescu C, Wilson AC, Andreoli SP (2013) Nonsteroidal anti-inflammatory drugs are an important cause of acute kidney injury in children. J Pediatr 162:1153-1159. e1151

Article  CAS  PubMed  Google Scholar 

Ting JY, McDougal K, De Mello A, Kwan E, Mammen C (2023) Acute kidney injury among preterm infants receiving nonsteroidal anti-inflammatory drugs: A pilot study. Pediatr Neonatol 64:313–318

Article  PubMed  Google Scholar 

Yousif Z, Awdishu L (2023) Drug-induced acute kidney injury risk prediction models. Nephron 147:44–47

Article  CAS  PubMed  Google Scholar 

Joint Committee on Infant Hearing of the American Academy of P, Muse C, Harrison J, Yoshinaga-Itano C, Grimes A, Brookhouser PE, Epstein S, Buchman C, Mehl A, Vohr B, Moeller MP, Martin P, Benedict BS, Scoggins B, Crace J, King M, Sette A, Martin B (2013) Supplement to the JCIH 2007 position statement: principles and guidelines for early intervention after confirmation that a child is deaf or hard of hearing. Pediatrics 131:e1324-1349

Article  Google Scholar 

American Academy of Pediatrics JCoIH (2007) Year 2007 position statement: Principles and guidelines for early hearing detection and intervention programs. Pediatrics 120:898–921

Article  Google Scholar 

Marissen J, Fortmann I, Humberg A, Rausch TK, Simon A, Stein A, Schaible T, Eichhorn J, Wintgens J, Roll C, Heitmann F, Herting E, Gopel W, Hartel C (2020) Vancomycin-induced ototoxicity in very-low-birthweight infants. J Antimicrob Chemother 75:2291–2298

CAS  PubMed  Google Scholar 

Cohen-Wolkowiez M, Watt KM, Zhou C, Bloom BT, Poindexter B, Castro L, Gao J, Capparelli EV, Benjamin DK Jr, Smith PB (2014) Developmental pharmacokinetics of piperacillin and tazobactam using plasma and dried blood spots from infants. Antimicrob Agents Chemother 58:2856–2865

Article  PubMed  PubMed Central  Google Scholar 

Veldman A, Richter E, Hacker C, Fischer D (2022) The Use of Off-Label Medications in Newborn Infants Despite an Approved Alternative Being Available-Results of a National Survey. Pharmacy (Basel) 10:19

Article  PubMed  Google Scholar 

Johnston PG, Gillam-Krakauer M, Fuller MP, Reese J (2012) Evidence-based use of indomethacin and ibuprofen in the neonatal intensive care unit. Clin Perinatol 39:111–136

Article  PubMed  PubMed Central  Google Scholar 

Pacifici GM (2016) The effects and pharmacokinetics of acyclovir in neonates. Int J Pediatr 4:4099–4115

CAS  Google Scholar 

Kimberlin DW, Lin C-Y, Jacobs RF, Powell DA, Corey L, Gruber WC, Rathore M, Bradley JS, Diaz PS, Kumar M (2001) Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics 108:230–238

Article  CAS  PubMed  Google Scholar 

Testoni D, Smith PB, Benjamin DK Jr (2012) The use of antifungal therapy in neonatal intensive care. Clin Perinatol 39:83–98

Article  PubMed  PubMed Central  Google Scholar 

Gantenbein MH, Bauersfeld U, Baenziger O, Frey B, Neuhaus T, Sennhauser F, Bernet V (2008) Side effects of angiotensin converting enzyme inhibitor (captopril) in newborns and young infants. J Perinat Med 36:448–452

Article  CAS  PubMed  Google Scholar 

Ku LC, Zimmerman K, Benjamin DK, Clark RH, Hornik CP, Smith PB, Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering C (2017) Safety of Enalapril in Infants Admitted to the Neonatal Intensive Care Unit. Pediatr Cardiol 38:155–161

Article  PubMed  Google Scholar 

Guignard JP, Iacobelli S (2021) Use of diuretics in the neonatal period. Pediatr Nephrol 36:2687–2695

Article  PubMed  Google Scholar 

Segar JL (2012) Neonatal diuretic therapy: furosemide, thiazides, and spironolactone. Clin Perinatol 39:209–220

Article  PubMed  Google Scholar 

Menon S, Kirkendall ES, Nguyen H, Goldstein SL (2014) Acute kidney injury associated with high nephrotoxic medication exposure leads to chronic kidney disease after 6 months. J Pediatr 165:522-527 e522

Article  CAS  PubMed  Google Scholar 

Kane-Gill SL, Goldstein SL (2015) Drug-Induced Acute Kidney Injury: A Focus on Risk Assessment for Prevention. Crit Care Clin 31:675–684

Article  PubMed  Google Scholar 

Awdishu L (2017) Drug-induced kidney disease in the ICU: mechanisms, susceptibility, diagnosis and management strategies. Curr Opin Crit Care 23:484–490

Article  PubMed  Google Scholar 

Amatullah N, Stottlemyer BA, Zerfas I, Stevens C, Ozrazgat-Baslanti T, Bihorac A, Kane-Gill SL (2023) Challenges in Pharmacovigilance: Variability in the Criteria for Determining Drug-Associated Acute Kidney Injury in Retrospective, Observational Studies. Nephron. 147:725–732

Article  PubMed  Google Scholar 

Gerber JS, Newland JG, Coffin SE, Hall M, Thurm C, Prasad PA, Feudtner C, Zaoutis TE (2010) Variability in antibiotic use at children’s hospitals. Pediatrics 126:1067–1073

Article  PubMed  Google Scholar 

Leroux S, Zhao W, Bétrémieux P, Pladys P, Saliba E, Jacqz-Aigrain E, on behalf of the French Society of Neonatology (2015) Therapeutic guidelines for prescribing antibiotics in neonates should be evidence-based: a French national survey. Arch Dis Child 100:394–398

Article  PubMed  Google Scholar 

Hsieh EM, Hornik CP, Clark RH, Laughon MM, Benjamin DK Jr, Smith PB, Best Pharmaceuticals for Children Act-Pediatric Trials N (2014) Medication use in the neonatal intensive care unit. Am J Perinatol 31:811–821

Article  PubMed  Google Scholar 

Boulkedid R, Abdoul H, Loustau M, Sibony O, Alberti C (2011) Using and reporting the Delphi method for selecting healthcare quality indicators: a systematic review. PLoS ONE 6:e20476

Article  CAS  PubMed  PubMed Central  Google Scholar 

Humphrey-Murto S, Varpio L, Wood TJ, Gonsalves C, Ufholz LA, Mascioli K, Wang C, Foth T (2017) The Use of the Delphi and Other Consensus Group Methods in Medical Education Research: A Review. Acad Med 92:1491–1498

Article  PubMed 

Comments (0)

No login
gif