Croughs PD, Li B, Hoogkamp-Korstanje JA, Stobberingh E, Group ARS. Thirteen years of antibiotic susceptibility surveillance of Pseudomonas aeruginosa from intensive care units and urology services in The Netherlands. Eur J Clin Microbiol Infect Dis. 2013;32:283–8.
Article CAS PubMed Google Scholar
Gerver SM, Nsonwu O, Thelwall S, Brown CS, Hope R. Trends in rates of incidence, fatality and antimicrobial resistance among isolates of Pseudomonas spp. causing bloodstream infections in England between 2009 and 2018: results from a national voluntary surveillance scheme. J Hosp Infect. 2022;120:73–80.
Article CAS PubMed Google Scholar
Ng QX, Ong NY, Lee DYX, Yau CE, Lim YL, Kwa ALH, et al. Trends in Pseudomonas aeruginosa (P. aeruginosa) bacteremia during the COVID-19 pandemic: a systematic review. Antibiotics. 2023;12:409.
Article PubMed PubMed Central Google Scholar
Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009;22:582–610.
Article CAS PubMed PubMed Central Google Scholar
Harris AA, Goodman L, Levin S. Community-acquired Pseudomonas aeruginosa pneumonia associated with the use of a home humidifier. West J Med. 1984;141:521–3.
CAS PubMed PubMed Central Google Scholar
Sadikot RT, Blackwell TS, Christman JW, Prince AS. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2005;171:1209–23.
Article PubMed PubMed Central Google Scholar
Reig S, Le Gouellec A, Bleves S. What is new in the anti–Pseudomonas aeruginosa clinical development pipeline since the 2017 WHO alert? Front Cell Infect Microbiol. 2022;12:909731.
Article CAS PubMed PubMed Central Google Scholar
Sindeldecker D, Stoodley P. The many antibiotic resistance and tolerance strategies of Pseudomonas aeruginosa. Biofilm. 2021;3:100056.
Article CAS PubMed PubMed Central Google Scholar
Lyu J, Chen H, Bao J, Liu S, Chen Y, Cui X, et al. Clinical distribution and drug resistance of Pseudomonas aeruginosa in Guangzhou, China from 2017 to 2021. J Clin Med. 2023;12:1189.
Article CAS PubMed PubMed Central Google Scholar
Horcajada JP, Montero M, Oliver A, Sorlí L, Luque S, Gómez-Zorrilla S, et al. Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections. Clin Microbiol Rev. 2019;32:e00031–19.
Article CAS PubMed PubMed Central Google Scholar
Thaden JT, Park LP, Maskarinec SA, Ruffin F, Fowler VG, van Duin D. Results from a 13-year prospective cohort study show increased mortality associated with bloodstream infections caused by Pseudomonas aeruginosa compared to other bacteria. Antimicrob Agents Chemother. 2017;61:e02671–16.
Article PubMed PubMed Central Google Scholar
Micek ST, Welch EC, Khan J, Pervez M, Doherty JA, Reichley RM, et al. Resistance to empiric antimicrobial treatment predicts outcome in severe sepsis associated with Gram-negative bacteremia. J Hosp Med. 2011;6:405–10.
Williams FN, Herndon DN, Hawkins HK, Lee JO, Cox RA, Kulp GA, et al. The leading causes of death after burn injury in a single pediatric burn center. Crit Care. 2009;13:R183.
Article PubMed PubMed Central Google Scholar
Graham BS, Ambrosino DM. History of passive antibody administration for prevention and treatment of infectious diseases. Curr Opin HIV AIDS. 2015;10:129–34.
Article CAS PubMed PubMed Central Google Scholar
Casadevall A, Pirofski LA, Joyner MJ. The principles of antibody therapy for infectious diseases with relevance for COVID-19. mBio. 2021;12:e03372–20.
Article CAS PubMed PubMed Central Google Scholar
Seixas AMM, Sousa SA, Leitão JH. Antibody-based immunotherapies as a tool for tackling multidrug-resistant bacterial infections. Vaccines. 2022;10:1789.
Article CAS PubMed PubMed Central Google Scholar
Motley MP, Banerjee K, Fries BC. Monoclonal antibody-based therapies for bacterial infections. Curr Opin Infect Dis. 2019;32:210–6.
Article CAS PubMed PubMed Central Google Scholar
DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, et al. A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014;6:262ra155.
Wei J, Yang Y, Wang G, Liu M. Current landscape and future directions of bispecific antibodies in cancer immunotherapy. Front Immunol. 2022;13:1035276.
Article CAS PubMed PubMed Central Google Scholar
Brinkmann U, Kontermann RE. The making of bispecific antibodies. MAbs. 2017;9:182–212.
Article CAS PubMed PubMed Central Google Scholar
Rghei AD, van Lieshout LP, Cao W, He S, Tierney K, Lopes JA, et al. Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep. Gene Ther. 2022; https://doi.org/10.1038/s41434-022-00361-2.
Hinderer C, Bell P, Louboutin JP, Zhu Y, Yu H, Lin G, et al. Neonatal systemic AAV induces tolerance to CNS gene therapy in MPS I dogs and nonhuman primates. Mol Ther. 2015;23:1298–307.
Article CAS PubMed PubMed Central Google Scholar
van den Berg FT, Makoah NA, Ali SA, Scott TA, Mapengo RE, Mutsvunguma LZ, et al. AAV-mediated expression of broadly neutralizing and vaccine-like antibodies targeting the HIV-1 Envelope V2 region. Mol Ther Methods Clin Dev. 2019;14:100–12.
Article PubMed PubMed Central Google Scholar
van Lieshout LP, Soule G, Sorensen D, Frost KL, He S, Tierney K, et al. Intramuscular adeno-associated virus-mediated expression of monoclonal antibodies provides 100% protection against Ebola virus infection in mice. J Infect Dis. 2018;217:916–25.
Article PubMed PubMed Central Google Scholar
Balazs AB, Ouyang Y, Hong CM, Chen J, Nguyen SM, Rao DS, et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med. 2014;20:296–300.
Article CAS PubMed PubMed Central Google Scholar
Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D. Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nat Biotechnol. 2013;31:647–52.
Article CAS PubMed PubMed Central Google Scholar
Guilleman MM, Stevens BAY, Van Lieshout LP, Rghei AD, Pei Y, Santry LA, et al. AAV-mediated delivery of actoxumab and bezlotoxumab results in serum and mucosal antibody concentrations that provide protection from C. difficile toxin challenge. Gene Ther. 2023;30:455–62.
Article CAS PubMed Google Scholar
Deal C, Balazs AB, Espinosa DA, Zavala F, Baltimore D, Ketner G. Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice. Proc Natl Acad Sci USA. 2014;111:12528–32.
Article CAS PubMed PubMed Central Google Scholar
Welles HC, Jennewein MF, Mason RD, Narpala S, Wang L, Cheng C, et al. Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge. PLoS Pathog. 2018;14:e1007395.
Article PubMed PubMed Central Google Scholar
Rghei AD, Cao W, He S, Lopes JA, Zielinska N, Pei Y, et al. AAV-vectored expression of Marburg virus-neutralizing antibody MR191 provides complete protection from challenge in a guinea pig model. J Infect Dis. 2023;228:S682–S690.
Rghei AD, Yates JGE, Lopes JA, Zhan X, Guilleman MM, Pei Y, et al. Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis. Gene Ther. 2023. https://doi.org/10.1038/s41434-023-00385-2. Online ahead of print.
Milla CE, Chmiel JF, Accurso FJ, VanDevanter DR, Konstan MW, Yarranton G, et al. Anti-PcrV antibody in cystic fibrosis: a novel approach targeting Pseudomonas aeruginosa airway infection. Pediatr Pulmonol. 2014;49:650–8.
DiGiandomenico A, Warrener P, Hamilton M, Guillard S, Ravn P, Minter R, et al. Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening. J Exp Med. 2012;209:1273–87.
Article CAS PubMed PubMed Central Google Scholar
Fang J, Qian JJ, Yi S, Harding TC, Tu GH, VanRoey M, et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nat Biotechnol. 2005;23:584–90.
Article CAS PubMed Google Scholar
Choi JH, Yu NK, Baek GC, Bakes J, Seo D, Nam HJ, et al. Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons. Mol Brain. 2014;7:17.
Article PubMed PubMed Central Google Scholar
Rghei AD, Stevens BAY, Thomas SP, Yates JGE, McLeod BM, Karimi K, et al. Production of adeno-associated virus vectors in cell stacks for preclinical studies in large animal models. J Vis Exp. 2021;30.
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