Fusheng Wang is the trial’s principal investigator. Fusheng Wang, Yonggang Li, Z Xu and Yuanyuan Li conceptualized the study and designed its methods. Yonggang Li, Z Xu, Yuanyuan Li, T Jiang, F Meng, J Fu and L Huang recruited participants and performed clinical procedures. Fusheng Wang, Yonggang Li, Z Xu, Yuanyuan Li, Fengchao Wang and X Wang analyzed the data, interpreted the results and drafted the manuscript. All authors revised and reviewed the manuscript and contributed to the final approval of the manuscript.